DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fancd2 and Fancd2

DIOPT Version :9

Sequence 1:	NP_996246.1	Gene:	Fancd2 / 2768674	FlyBaseID:	FBgn0038827	Length:	1478	Species:	Drosophila melanogaster
Sequence 2:	NP_001028416.2	Gene:	Fancd2 / 211651	MGIID:	2448480	Length:	1450	Species:	Mus musculus

Alignment Length:	1546	Identity:	367/1546 - (23%)
Similarity:	673/1546 - (43%)	Gaps:	256/1546 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 TQSSSRN--IATLSRQPNNFFEL---------VLVRAGVQLDQGDSL-ILACDHVPIVSKLREIF 124
            |:.:|:.  ::.|:::.:|..|:         :|..:|:.|..|::. .|..|.|....||.:..
Mouse    17 TEDASKTMPLSKLAKKSHNSHEVEENGSVFVKLLKASGLTLKTGENQNQLGVDQVIFQRKLFQAL 81

  Fly   125 TSASSYTDKMETFKTGLNAAMAPGSKLVQKLLTGCTVDAAGEEQIYQSQNSM--FMN------FL 181
            ....:|...:|.|..||. :....|:.::..|..|       |::...:.||  |.:      .|
Mouse    82 RKHPAYPKVIEEFVNGLE-SYTEDSESLRNCLLSC-------ERLQDEEASMGTFYSKSLIKLLL 138

  Fly   182 MIDFMRDACVEVLLNKIE----EVAKSDRVIMGKAAIPLPLLPLMLTQLRYLTASHKV----EIY 238
            .||.::.|.:::|..|:.    |....|.:.|.:         |::.||::|   .::    ::.
Mouse   139 GIDILQPAIIKMLFEKVPQFLFESENRDGINMAR---------LIINQLKWL---DRIVDGKDLT 191

  Fly   239 SRIEVIFNRATESAKLDIIANAELILDASMH----DEFVELLNINYSSTEDLFHMTTVQTLGNLS 299
            :::..:.:.|..:.:.|.|.:...||..|.|    .|..|||..|.|.|     :..:....:|.
Mouse   192 AQMMQLISVAPVNLQHDFITSLPEILGDSQHANVGKELGELLVQNTSLT-----VPILDVFSSLR 251

  Fly   300 LSDRTQAKLRVRILDFATSGQCSDAILPHLIRLLLNVLKIDTDDSVRDLIGSLRGIFNWRHTNET 364
            |.....:|:|..::...:|.:..|  .|.:::.||:.:   ||.:..::|..||...|.:.....
Mouse   252 LDPNFLSKIRQLVMGKLSSVRLED--FPVIVKFLLHSV---TDTTSLEVIAELRENLNVQQFILP 311

  Fly   365 EKISASEDSKKSQ-----------------LELFGFLELGLIR-----SKKFYQACQRSSASVPA 407
            .:|.||:...||:                 :.:|..:: ..||     |:.:::|.:|..:   |
Mouse   312 SRIQASQSKLKSKGLASSSGNQENSDKDCIVLVFDVIK-SAIRYEKTISEAWFKAIERIES---A 372

  Fly   408 AEFTSFDMILLLLLIHVNEDNSLYIENILRRRIKLEHITVSILEEIRQHYRHILEQHITTLMNIL 472
            ||..:.|:::||::...:......:|.:||.:|:.:.|...:|:.....:..:|:....:::.:.
Mouse   373 AEHKALDVVMLLIIYSTSTQTKKGVEKLLRNKIQSDCIQEQLLDSAFSTHYLVLKDICPSILLLA 437

  Fly   473 HDFMREKNRIVSDFAKSSYSILFKIFNS-IQKNILKKLLELTCDKSSPHLTTMALELLRELQRKS 536
            ......:::.:..|....|...||.|:: .|:.::..|:...|..:...:.| ||::|.||...:
Mouse   438 QTLFHSQDQRIILFGSLLYKYAFKFFDTYCQQEVVGALVTHVCSGTEAEVDT-ALDVLLELIVLN 501

  Fly   537 AKDVQNCATLLIPMLDRISDLSLTQTRVAMDLLCHVAF-PDPNLSPCLQLQEQVDMVVKKQLINS 600
            |..::..|..:..:||.:.::|..|.|....:|..:|| ..|..|.  .:|:.:.:|::|||.::
Mouse   502 ASAMRLNAAFVKGILDYLENMSPQQIRKIFCILSTLAFSQQPGTSN--HIQDDMHLVIRKQLSST 564

  Fly   601 IDNIKKQGIIGCVQLIDAMARIANNGVDRDEFIASVENVDSLPDGRGKMAANLII--RTEAS--- 660
            :...|..||||.|.:...||.      ||           |:|....:.:||:..  ||:.:
Mouse   565 VFKYKLIGIIGAVTMAGIMAE------DR-----------SVPSNSSQRSANVSSEQRTQVTSLL 612

  Fly   661 --IGNSTE----SLALFFEELATVFNQRNEGTSGCELDNQFIAWACDLVTFRFQASFVTE--NVP 717
              :.:.||    :.:|:::|.|.:..:|       :|..:.:.|....:...||.:||.:  ..|
Mouse   613 QLVHSCTEHSPWASSLYYDEFANLIQER-------KLAPKTLEWVGQTIFNDFQDAFVVDFCAAP 670

  Fly   718 ETLKGIKLEYQLNINELDDTDANTESDVLNIGINISKLVLSPKVKACD--------------SIY 768
            |.      ::...:..|...:..:..|    ||.|:.|.|..:..|.|              |..
Mouse   671 EG------DFPFPVKALYGLEEYSTQD----GIVINLLPLFYQECAKDASRATSQESSQRSMSSL 725

  Fly   769 VLAPLFNYVRVLYKHRHQDSLESINALLGCAIVLPSFFEDDNYVSVFENFEAEQQKDILSIYFHT 833
            .||..|..:|:....:|..:|:.|:.||.|.:.||.....:.    .|:..|:.:..:.|:.|.|
Mouse   726 CLASHFRLLRLCVARQHDGNLDEIDGLLDCPLFLPDLEPGEK----LESMSAKDRSLMCSLTFLT 786

  Fly   834 VNWMRVSISAFASQRDPPTRRRVLSRLGELIRIEQRMKPLLARAPVDFVAPPYQFL--------- 889
            .||.|..::||..|..|..:.:|||||.:|:.::..::..||..| |:| ||:..:
Mouse   787 FNWFREVVNAFCQQTSPEMKGKVLSRLKDLVELQGILEKYLAVIP-DYV-PPFASVDLDTLDMMP 849

  Fly   890 ---TNVKLSNQNQKRPGPKPAAKLNATLPEPDLTGNQPSIAD--FTIKVGQC------------- 936
               :.|...|:|:.:.|.|          :.....|:.|.:|  .|....:|
Mouse   850 RSSSAVAAKNRNKGKTGGK----------KQKADSNKASCSDTLLTEDTSECDMAPSGRSHVDKE 904

  Fly   937 KTVKTKTDFEQMYGPRERYRPMEVEIIMLL---VEQKFVLNHQLEEEQMGEF-LGLLELRFLLED 997
            .|.|....|..:...|..:|.:::|:..:|   :..||:|:.::..|..... ||..||.|||||
Mouse   905 STGKEGKTFVSLQNYRAFFRELDIEVFSILHSGLVTKFILDTEMHTEATEVVQLGPAELLFLLED 969

  Fly   998 VVQKLE----------AAVLRHHDSYDADSFRPHLAKPEDFICDLLPCLHEVNNHLITLGEAIDN 1052
            :.||||          ....::....:......|....:|.:..::..|..:.|||    |.|.|
Mouse   970 LSQKLENMLTAPFAKRICCFKNKGRQNIGFSHLHQRSVQDIVHCVVQLLTPMCNHL----ENIHN 1030

  Fly  1053 --QLTEVSHVYSN---LDLFKDQFCYIKSCFGLCVRLFALYFAWSEWSDKSQEQLLHKSLLKLQP 1112
              |.....|:.::   ....::|.. :..|:...:::....|||..::.:|:.:|||.:|..|
Mouse  1031 FFQCLGAEHLSADDKARATAQEQHT-MACCYQKLLQVLHALFAWKGFTHQSKHRLLHSALEVL-- 1092

  Fly  1113 KTQWKRLEK-QSVPQLANLTFQYFLKYEKSVLNLSTAVHLHRLLCNLLKLGSLQSDASQPRFQQA 1176
            ..:.|::|: |.:.:|.:.:|.|...:..||.:....::|.|||..||:..::.:       |:.
Mouse  1093 SNRLKQMEQDQPLEELVSQSFSYLQNFHHSVPSFQCGLYLLRLLMALLEKSAVPN-------QKK 1150

  Fly  1177 EDLRILCGTLLRRKWFHYSGTLDKGGQCNIYLDELVKGFLKKS-NAKSQTELLT-----ELVKQC 1235
            |.|..|...||.|.|.|  |..:|....|.:|.:::..:|:.: |.....|.:|     |||..
Mouse  1151 EKLASLAKQLLCRAWPH--GEKEKNPTFNDHLHDVLYIYLEHTDNVLKAIEEITGVGVPELVSA- 1212

  Fly  1236 SILNTKDKALTSFPNFKKANFPLLFRGL---CEVLIHSLSGQVSVDSR---GDKLKLWESAVDLL 1294
                .||.|.::||...:..|.:.||.:   .|..:..|....:.||:   .:||..|..||...
Mouse  1213 ----PKDAASSTFPTLTRHTFVIFFRVMMAELEKTVKGLQAGTAADSQQVHEEKLLYWNMAVRDF 1273

  Fly  1295 NGLLSIVQQVEQPRNFGLFLKHSLLFLKLLLQHGMSALESIVREDPERLTRFLHELQKVTRFLHQ 1359
            :.||::::..:......:.||:...|::..|:..|..|:...|:..|.:...|..||..||.||.
Mouse  1274 SILLNLMKVFDSYPVLHVCLKYGRRFVEAFLKQCMPLLDFSFRKHREDVLSLLQTLQLNTRLLHH 1338

  Fly  1360 LCCHSKSIKNTAIISYIPSLRETIETLVFRVKALLAANNCHSAFHMGNMINRDLHGDSIIT--PR 1422
            ||.|||..::|.:..::|.|::::|.||.||||:|..|||..||.:|.:.||||.|:.||:  |.
Mouse  1339 LCGHSKIRQDTRLTKHVPLLKKSLELLVCRVKAMLVLNNCREAFWLGTLKNRDLQGEEIISQDPS 1403

  Fly  1423 SSFAGEENSDDELPADDTSVDETVLGDDMGITAVSVSTRPSDGSRRSKSSS 1473
            ||.:..|:|:|.:.:..:....|..|:|    ..|...:..|......|||
Mouse  1404 SSESNAEDSEDGVTSHVSRNRATEDGED----EASDEQKDQDSDESDDSSS 1450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fancd2	NP_996246.1	FANC	132..1422	CDD:302591	338/1421 (24%)
Fancd2	NP_001028416.2	Interaction with FANCE. /evidence=ECO:0000250	1..289		64/303 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37		4/21 (19%)
		FancD2	33..1415	CDD:291305	361/1523 (24%)
		Interaction with BRCA2. /evidence=ECO:0000250	246..357		27/132 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	853..879		4/27 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1398..1450		5/21 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839752
Domainoid	1	1.000	265	1.000	Domainoid score	I1882
eggNOG	1	0.900	-	-		E1_KOG4712
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13212
Inparanoid	1	1.050	290	1.000	Inparanoid score	I2781
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55850
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006538
OrthoInspector	1	1.000	-	-		oto91886
orthoMCL	1	0.900	-	-		OOG6_103750
Panther	1	1.100	-	-	LDO	PTHR32086
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6920
SonicParanoid	1	1.000	-	-		X5513
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.830