Protein Alignment Fancd2 and fancd2

DIOPT Version :9

• Sequence 1: NP_996246.1
• Gene: Fancd2 / 2768674
• FlyBaseID: FBgn0038827
• Length: 1478
• Species: Drosophila melanogaster
• Sequence 2: XP_002934277.3
• Gene: fancd2 / 100487938
• XenbaseID: XB-GENE-984801
• Length: 1449
• Species: Xenopus tropicalis
• Alignment Length: 1495
• Identity: 339/1495 - (22%)
• Similarity: 666/1495 - (44%)
• Gaps: 201/1495 - (13%)

  Fly    71 RTQSSSRNIATLSR----QPNNFFELVLVRAGVQLDQGD-SLILACDHVPIVSKLREIFTSASSY 130
            :.::||:....|.:    :.::.|..:|..:|:.|..|| ...:|.|......||.:.......:
 Frog    31 KCRTSSKKTKALPQDGVVENDSIFVQLLKSSGMTLKSGDRQNEIAVDQAVFQKKLHQALRKHPRH 95

  Fly   131 TDKMETFKTGLNAAMAPGSKLVQKLL-TGCTVDAAGEEQIYQSQNSMFMNFLMIDFMRDACVEVL 194
            .:.::.|.:||.:.:.........|| .|...:......:....:|:....|.::.::::.:..|
 Frog    96 PNVIQEFISGLESHIEDRDTFRNCLLPCGNRQETEASTMVGSFHDSLMKLLLGLEILQESVINTL 160

  Fly   195 LNKIEEVAKSDRVIMGKAAIPLPLLPLMLTQLRYLTASHKV----EIYSRIEVIFNRATESAKLD 255
            ..|:.|.....   :|...|.:|  .|::.|.::|   .::    ::..:|..:.:.|....:.|
 Frog   161 FEKLPEFLYDS---VGSDGISIP--RLIINQFKWL---DRILDCKDLTLKIMQLISVAPVDIQHD 217

  Fly   256 IIANAELILDASMHDEFVELLNINYSSTEDLFHMTTVQTLGNLSLSDRTQAKLRVRILDFATSGQ 320
            ||.:...||:.|.|::....||........| .:..:..|.:|:::....:::|..::...::.:
 Frog   218 IITSLPEILEDSQHNDVARELNSLLQQNTQL-TVPILDALSSLNINTDLLSEVRQSVMSTLSAVE 281

  Fly   321 CSDAILPHLIRLLLNVLKIDTDDSVRDLIGSLRGIFNWRHTNETEKISASEDSKKSQLELFG--- 382
            ..|  ||.:|:.:|:.  :...|:| ::|..||...:....:...:|.|:::.::::.:...
 Frog   282 LED--LPVIIKFILHA--VTPSDAV-EVISELRKKLDLESCSSLAQIHATQNKERNKPQAGSSVN 341

  Fly   383 --------FLELGLIRSKKFYQACQRSSASVPAAEFTSFDMI--------LLLLLIHVNEDNS-- 429
                    .|.:.:|:|...:|. ..|.|.:.|.|  :.|.:        ::||:::..:.||
 Frog   342 KTKSSDCVSLMMDVIKSAVRFQK-HMSEAWIKAIE--NVDTVGDHKVSDLIVLLILYTTQTNSSK 403

  Fly   430 LYIENILRRRIKLEHITVSILEEIRQHYRHILEQHITTLMNILHDFMREKNRIVSDFAKSSYSIL 494
            ...|.:||.:|:...|:..:|:...:::..:|..:..:::::....:|...:.|..|....|...
 Frog   404 KQAERVLRNKIRSGFISDQLLQNAFRNHSQVLRDYFPSILSLAQSMLRSAEQSVVSFGSLMYKSA 468

  Fly   495 FKIFNS-IQKNILKKLLELTCDKSSPHLTTMALELLRELQRKSAKDVQNCATLLIPMLDRISDLS 558
            |.:|:| .|:.::..|:...| ...|....::|::|.:|....|..|...|..:..:||.:.:|:
 Frog   469 FSVFDSYCQQEVVGALVTHVC-SGYPAEVDVSLDVLTDLVSSHAAAVALYAVFVKGILDYLDNLN 532

  Fly   559 LTQTRVAMDLLCHVAFPDPNLSPCLQLQEQVDMVVKKQLINSIDNIKKQGIIGCVQLIDAMARIA 623
            ..|.|....:|..:||.......  .:|:.:.:|::|||.::....|:.||||.|:::.:||...
 Frog   533 AQQIRKLFHILSVLAFSRGQEGS--HIQDDMFIVIRKQLSSTALKYKRIGIIGAVRMVGSMAVNK 595

  Fly   624 NNGVDRDEFIASVENVDSLPDGRGKMAANLIIRTEASIGNSTESLALFFEELATVFNQRNEGTSG 688
            .:|....|     .|..|....|...|...:::|.:.  ...|:.||:::||:::..:||
 Frog   596 KHGSKNPE-----NNPLSAESFRQVTALLELVQTCSE--QVPEASALYYDELSSLVQKRN----- 648

  Fly   689 CELDNQFIAWACDLVTFRFQASFVTENVPETLKG-----IKLEYQLNINELDDTDANTESDVLNI 748
              ||...::|....|...||..||.:..| |::|     :|..|  |::| ||:......::|.:
 Frog   649 --LDPLVMSWVGKTVLTDFQDDFVDDLTP-TVEGNYIFPVKAMY--NLDE-DDSQGGIAINILPV 707

  Fly   749 ------------GINISKLVLSPKVKACDSIYVLAPLFNYVRVLYKHRHQDSLESINALLGCAIV 801
                        ..|..:.|:||   .|     |:|.|..:|:..:.:|:.:||.|:|||||
 Frog   708 LSKDMCSRGAEQAANKEERVVSP---IC-----LSPFFRLLRLCIEDQHEGNLEEIDALLGC--- 761

  Fly   802 LPSFFEDDNYVSVFENFEAEQQKDILSIYFHTVNWMRVSISAFASQRDPPTRRRVLSRLGELIRI 866
             |.:..|.......|:...::::.:.|:.|..:||.|..::||..|:|...:.:||:||..:..:
 Frog   762 -PLYLTDLEITEKMESLSKQEREFLCSLLFFALNWFREIVNAFCKQQDLDMKSKVLTRLQNITWL 825

  Fly   867 EQRMKPLLARAP------VDFVAPPYQFLTNVKLS---NQNQKRPGPKPAAKLNATLPEPDLTGN 922
            :..::..||.:|      ..|.:.|.:.|.:...|   .:.:|....|.||..|::.....|..:
 Frog   826 QSVLEKCLAASPGYIPPSAQFDSEPQEVLPSAIASAPAKKAKKGKTQKSAASKNSSADSSQLEEH 890

  Fly   923 QPSIADFTIKVGQCKTVKTKTDFEQMYGP-------RERYRPMEVEIIMLLVEQKFVLNHQLEEE 980
            |.:      :..:.:..:.:.:.|:...|       |..:|.:::|:..:|  |..:|...:.:.
 Frog   891 QDT------EKSELEKTQPEKEKEESSKPTINLNSYRAYFRELDLEVFTVL--QCGLLTRSVLDS 947

  Fly   981 QMGE------FLGLLELRFLLEDVVQKLE---------AAVLRHHDSYDADSFRPHLAKPEDFIC 1030
            :|..      .||..||.|||||:.:|.|         ...|:...|.:....:.|...|::...
 Frog   948 EMHTKATEVVQLGPAELVFLLEDLFRKTEHMLTSTVKRVMFLKVKGSRNIGFSQLHQKTPQEVAQ 1012

  Fly  1031 DLLPCLHEVNNHLITLGEAIDNQLTEVSHVY--------------SNLDLFKDQFCYIKSCFGLC 1081
            .::..|:.:.||            ||..|.|              .::|:.:.|  |:.:|:.|.
 Frog  1013 AVIHLLNSLCNH------------TENMHNYFQTLMLENHGVVDAPSVDIKEHQ--YMSTCYQLL 1063

  Fly  1082 VRLFALYFAWSEWSDKSQEQLLHKSLLKLQPKTQWKRLEKQSVPQLANL---TFQYFLKYEKSVL 1143
            :::|...|.||.:|.....:||..:|:.|..:.:    |.::.|.|..|   :|.|......||.
 Frog  1064 LQVFHTLFCWSGFSQHENRKLLKSALIALAGRLK----ETEAEPALDELVRQSFNYLKNLHSSVP 1124

  Fly  1144 NLSTAVHLHRLLCNLLKLGSLQSDASQPRFQQAEDLRILCGTLLRRKWFHYSGTLDKGGQCNIYL 1208
            ..|:|:.|.:||..:.:..::        ....|.:..:....|.:.|...||..:||.:.:..|
 Frog  1125 TCSSALCLTQLLIVIAEKANV--------LHYREQIASMAKQFLCQPWIQPSGEREKGTRYHENL 1181

  Fly  1209 DELVKGFLKKSN--AKSQTEL----LTELVKQCSILNTKDKALTSFPNFKKANFPLLFRGL---- 1263
            ..|:..:|:.::  .|:..|:    :.|||..     .||...:|:|...:..|.:.||.:
 Frog  1182 QSLLCIYLENTDDVLKAVEEIAGVGVPELVNA-----AKDAGSSSYPTLTRQTFIVFFRVMMDKL 1241

  Fly  1264 --CEVLIHSLSGQVSVDSRGDKLKLWESAVDLLNGLLSIVQQVEQPRNFGLFLKHSLLFLKLLLQ 1326
              |...|.|.....::..:.::|..|..||...:.|:::|:..:......:.||:..:|::..|:
 Frog  1242 EKCVKCIPSGKKAETLQEQTEQLLRWNLAVRDFHILVNLVKVFDSRPVLSICLKYGRMFVETFLK 1306

  Fly  1327 HGMSALESIVREDPERLTRFLHELQKVTRFLHQLCCHSKSIKNTAIISYIPSLRETIETLVFRVK 1391
            .||..|:...::..|.:...|..||..||.||.:|.|||..::||:.:::|.|::|:|..|:|||
 Frog  1307 LGMPLLDCCFKKHREDVQSLLKTLQLSTRQLHHMCGHSKIHQDTALTNHVPLLKKTLELFVYRVK 1371

  Fly  1392 ALLAANNCHSAFHMGNMINRDLHGDSIITPRSSFA-GEENSDDELP--ADDTSVDETVLGDDMGI 1453
            |:|..|||..||.:||:.||||.|:.|::..|..: |||..:.:||  .::|..:|...|.|..|
 Frog  1372 AMLVLNNCQDAFWLGNLKNRDLQGEEILSQVSQDSEGEEEQESQLPPEIEETEEEEENEGSDKEI 1436

  Fly  1454  1453
             Frog  1437  1436

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fancd2	NP_996246.1	FANC	132..1422	CDD:302591	315/1393 (23%)
fancd2	XP_002934277.3	FancD2	41..1405	CDD:405336	327/1452 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	275	1.000	Domainoid score	I1728
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13212
Inparanoid	1	1.050	307	1.000	Inparanoid score	I2593
OMA	1	1.010	-	-		QHG55850
OrthoDB	1	1.010	-	-		D33210at33208
OrthoFinder	1	1.000	-	-		FOG0006538
OrthoInspector	1	1.000	-	-		oto102201
Panther	1	1.100	-	-	LDO	PTHR32086
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5513
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.080