DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pxd and DUOX1

DIOPT Version :9

Sequence 1:NP_001163633.1 Gene:Pxd / 2768671 FlyBaseID:FBgn0004577 Length:690 Species:Drosophila melanogaster
Sequence 2:NP_059130.2 Gene:DUOX1 / 53905 HGNCID:3062 Length:1551 Species:Homo sapiens


Alignment Length:607 Identity:163/607 - (26%)
Similarity:253/607 - (41%) Gaps:120/607 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   109 DGSCNHLEQPGLGVANSKYGRLLTPKYADGISAPTRSVTGDELPSARLVSLVAFGEQDVPDPEFT 173
            ||..|:|.:...|...|:..||:...||||:..|                   .||..:|:|   
Human    33 DGWYNNLMEHRWGSKGSRLQRLVPASYADGVYQP-------------------LGEPHLPNP--- 75

  Fly   174 LHNMQWGQIMTHDMSMQAGGTQSKKHPT--------RCCTDDGRLIGLDTAHKTCFA----IIVP 226
                   :.:::.:|....|..|.::.|        ...:|   |:.::|  ..|.|    |.:|
Human    76 -------RDLSNTISRGPAGLASLRNRTVLGVFFGYHVLSD---LVSVET--PGCPAEFLNIRIP 128

  Fly   227 PHDPAY--SQVGTECLNFVRTLTDRDSNCQYQGGPAEQLTVVTSYLDLSLVYGNSIQQNSDIREF 289
            |.||.:  .|.|...|.|.|:..|.::. :....|.:....||.:||.|.:||:|...:..:|.|
Human   129 PGDPMFDPDQRGDVVLPFQRSRWDPETG-RSPSNPRDPANQVTGWLDGSAIYGSSHSWSDALRSF 192

  Fly   290 QGGRMIV--------EERNGAKWLPLSRNVTGDCDAVDASEVCYRSGDVRVNQNPGLAILQTILL 346
            ..|::..        :.:|...........||.    :.....|..|..|.|:.|.|..|..:..
Human   193 SRGQLASGPDPAFPRDSQNPLLMWAAPDPATGQ----NGPRGLYAFGAERGNREPFLQALGLLWF 253

  Fly   347 REHNRIADALSALNPHYDDRTLFQEARKINIAQYQQISYYEWLPIFLGGENMLKNRLIYKAPSGS 411
            |.||..|..|:..:|.::|..|||.|||..||.||.|:.|||||.||  :..|.....|:     
Human   254 RYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFL--QKTLPEYTGYR----- 311

  Fly   412 YINDFDPNIDPSVLNEHATAAFRYFHSQI-------------EGRLDLLSELRQVLGSLTLSDWF 463
                  |.:|||:.:|...|:.::..:.:             :|.::..|.:.:.| .:..|.|.
Human   312 ------PFLDPSISSEFVAASEQFLSTMVPPGVYMRNASCHFQGVINRNSSVSRAL-RVCNSYWS 369

  Fly   464 NRPGIIEVGDNFDSLTRGHATQPEELTDINFDRQIKHF-----LFRRNMPFGSDLRSLDIQRNRD 523
            .....::..::.|:|..|.|:|..|..|......::.|     .|.|     :|..:..:||.||
Human   370 REHPSLQSAEDVDALLLGMASQIAEREDHVLVEDVRDFWPGPLKFSR-----TDHLASCLQRGRD 429

  Fly   524 HGLASYNDMREFCGLRRAHSWEGYGDLIS---PPILEKLKSLYPSHED---VDLTVGASLEAHVA 582
            .||.||...|...||.....|:.....:|   ..:||...:||  ::|   ::|..|..||:|  
Human   430 LGLPSYTKARAALGLSPITRWQDINPALSRSNDTVLEATAALY--NQDLSWLELLPGGLLESH-- 490

  Fly   583 GALAGPTFLCILTEQFYRTRVGDRFFFENGDKLTG-FTPDQLEELRKASMARLLCDNGN-HISSM 645
             ...||.|..|:.|||.|.|.|||::|||  ...| |:..::||:|..::..:|....| ..|::
Human   491 -RDPGPLFSTIVLEQFVRLRDGDRYWFEN--TRNGLFSKKEIEEIRNTTLQDVLVAVINIDPSAL 552

  Fly   646 QPEAFRTVSHSNPIIPCSNIPQ 667
            ||..|  |.|...  ||   ||
Human   553 QPNVF--VWHKGD--PC---PQ 567

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PxdNP_001163633.1 An_peroxidase 105..643 CDD:281139 153/581 (26%)
peroxinectin_like 260..638 CDD:188655 114/410 (28%)
DUOX1NP_059130.2 Peroxidase-like, mediates peroxidase activity 26..593 163/607 (27%)
An_peroxidase 30..544 CDD:281139 152/575 (26%)
dual_peroxidase_like 32..591 CDD:188652 163/607 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 150..172 4/22 (18%)
EFh 820..881 CDD:238008
EF-hand_7 820..880 CDD:290234
EF-hand_7 857..921 CDD:290234
EFh 857..915 CDD:238008
Interaction with TXNDC11. /evidence=ECO:0000250 956..1248
Ferric_reduct 1091..1226 CDD:280043
NOX_Duox_like_FAD_NADP 1277..1551 CDD:99783
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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