DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pxd and DUOX2

DIOPT Version :9

Sequence 1:	NP_001163633.1	Gene:	Pxd / 2768671	FlyBaseID:	FBgn0004577	Length:	690	Species:	Drosophila melanogaster
Sequence 2:	NP_001350640.1	Gene:	DUOX2 / 50506	HGNCID:	13273	Length:	1548	Species:	Homo sapiens

Alignment Length:	603	Identity:	160/603 - (26%)
Similarity:	255/603 - (42%)	Gaps:	115/603 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 DGSCNHLEQPGLGVANSKYGRLLTPKYADGISAPTRSVTGDELPSARLVSLVAF-GEQDVPDPEF 172
            ||..|:|.....|....:..|.:...||||:   .:::...:||:.|.:|..|. |...:|
Human    39 DGWFNNLRHHERGAVGCRLQRRVPANYADGV---YQALEEPQLPNPRRLSNAATRGIAGLP---- 96

  Fly   173 TLHN-----MQWG-QIMTHDMSMQAGGTQSKKHPTRCCTDDGRLIGLDTAHKTCFAIIVPPHDPA 231
            :|||     :.:| .:::..:|::..|..::                      ...|.:||.||.
Human    97 SLHNRTVLGVFFGYHVLSDVVSVETPGCPAE----------------------FLNIRIPPGDPV 139

  Fly   232 Y--SQVGTECLNFVRTLTDRDSNCQYQGGPAEQLTVVTSYLDLSLVYGNSIQQNSDIREFQGGRM 294
            :  .|.|...|.|.|:..|.::. :....|.:....||.:||.|.:||:|...:..:|.|.||::
Human   140 FDPDQRGDVVLPFQRSRWDPETG-RSPSNPRDLANQVTGWLDGSAIYGSSHSWSDALRSFSGGQL 203

  Fly   295 IV--------EERNGAKWLPLSRNVTGDCDAVDASEVCYRSGDVRVNQNPGLAILQTILLREHNR 351
            ..        :.:|...........||.    :.....|..|..|.|:.|.|..|..:..|.||.
Human   204 ASGPDPAFPRDSQNPLLMWAAPDPATGQ----NGPRGLYAFGAERGNREPFLQALGLLWFRYHNL 264

  Fly   352 IADALSALNPHYDDRTLFQEARKINIAQYQQISYYEWLPIFLGGENMLKNRLIYKAPSGSYINDF 416
            .|..|:..:|.::|..|||.|||..||.||.|:.|||||.||  :..|.....|:
Human   265 WAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFL--QKTLPEYTGYR---------- 317

  Fly   417 DPNIDPSVLNEHATAAFRYFHSQIEGRLDLLS---ELRQVLGSLTLSDWFNRPGIIEVGDNF--- 475
             |.:|||:..|...|:.::|.:.:...:.:.:   ..|:|     |:..|.....:.|.:|:
Human   318 -PFLDPSISPEFVVASEQFFSTMVPPGVYMRNASCHFRKV-----LNKGFQSSQALRVCNNYWIR 376

  Fly   476 -----------DSLTRGHATQPEELTDINFDRQIKHF-----LFRRNMPFGSDLRSLDIQRNRDH 524
                       :.|..|.|:|..||.|......::.:     .|.|     :|..:..|||.||.
Human   377 ENPNLNSTQEVNELLLGMASQISELEDNIVVEDLRDYWPGPGKFSR-----TDYVASSIQRGRDM 436

  Fly   525 GLASYNDMREFCGLRRAHSWEGYGDLISPPILEKLKSLYPSHED---VDLTVGASLEAHVAGALA 586
            ||.||:......||....:|......:.|.:||...:||  ::|   ::|.:|..||:|   ...
Human   437 GLPSYSQALLAFGLDIPRNWSDLNPNVDPQVLEATAALY--NQDLSQLELLLGGLLESH---GDP 496

  Fly   587 GPTFLCILTEQFYRTRVGDRFFFENGDKLTG-FTPDQLEELRKASMARLLCDNGN-HISSMQPEA 649
            ||.|..|:.:||.|.|.|||::|||  ...| |:..::|::|..::..:|....| ..|::||..
Human   497 GPLFSAIVLDQFVRLRDGDRYWFEN--TRNGLFSKKEIEDIRNTTLRDVLVAVINIDPSALQPNV 559

  Fly   650 FRTVSHSNPIIPCSNIPQ 667
            |  |.|..  .||   ||
Human   560 F--VWHKG--APC---PQ 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pxd	NP_001163633.1	An_peroxidase	105..643	CDD:281139	150/577 (26%)
Pxd	NP_001163633.1	peroxinectin_like	260..638	CDD:188655	114/411 (28%)
DUOX2	NP_001350640.1	Peroxidase-like, mediates peroxidase activity. /evidence=ECO:0000250	30..596		160/603 (27%)
		dual_peroxidase_like	38..594	CDD:188652	160/603 (27%)
		EFh_PEF	<764..858	CDD:330173
		EFh	824..885	CDD:238008
		EF-hand_7	857..929	CDD:316058
		Interaction with TXNDC11. /evidence=ECO:0000250	960..1245
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	971..991
		Ferric_reduct	1088..1223	CDD:307763
		NOX_Duox_like_FAD_NADP	1274..1548	CDD:99783
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910