DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pxd and pxdn

DIOPT Version :9

Sequence 1:	NP_001163633.1	Gene:	Pxd / 2768671	FlyBaseID:	FBgn0004577	Length:	690	Species:	Drosophila melanogaster
Sequence 2:	NP_001076815.1	Gene:	pxdn / 493201	XenbaseID:	XB-GENE-923300	Length:	1460	Species:	Xenopus tropicalis

Alignment Length:	607	Identity:	211/607 - (34%)
Similarity:	312/607 - (51%)	Gaps:	58/607 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 VCEKTAYRTLDGSCNHLEQPGLGVANSKYGRLLTPKYADGISAPT----RSVTGDELPSARLVSL 159
            :|....|||.||:||:|:.|..|.:.:.:.|||...|.:|.:.|.    |...|..||..||||.
Frog   728 MCFHQKYRTHDGTCNNLQHPMWGASLTAFERLLKSVYENGFNLPRGISGRIYNGFPLPLPRLVST 792

  Fly   160 VAFGEQDV-PDPEFTLHNMQWGQIMTHDM-SMQAGGTQSK----KHPTRCCTDDGRLIGLDTAHK 218
            ...|...: ||.:||...|||||.:.||: |.....:|::    :..:..||:|.
Frog   793 TLIGTHTITPDEQFTHMLMQWGQFLDHDLDSTVVALSQARFSDGQDCSVVCTNDA---------- 847

  Fly   219 TCFAIIVPPHDPAYSQVGTECLNFVRT-------LTDRDSNCQYQGGPAEQLTVVTSYLDLSLVY 276
            .||.|:|||:||.... ...|::.||:       :|....|..|   |.||:..:|||:|.|.||
Frog   848 PCFPIMVPPNDPRVRN-NARCMSMVRSSPVCGSGMTSLLMNSVY---PREQMNQLTSYIDASNVY 908

  Fly   277 GNSIQQNSDIREFQGGRMIVE----ERNGAKWLPLSRNVTGDC--DAVDASEVCYRSGDVRVNQN 335
            |:|..::::||:....|.:::    :|:|...||.:.....:|  |..::...|:.:||.|.|:.
Frog   909 GSSDHESNEIRDSASHRGLLKQGIVQRSGKPLLPFATGPPTECMRDENESPIPCFLAGDHRANEQ 973

  Fly   336 PGLAILQTILLREHNRIADALSALNPHYDDRTLFQEARKINIAQYQQISYYEWLPIFLG--GENM 398
            .||..:.|:..|||||||..|..||||:|..|::.|.|||..||.|.|:|..|||...|  |..|
Frog   974 LGLTSMHTLWFREHNRIATELLRLNPHWDGDTIYHETRKIVGAQMQHITYSHWLPKIFGDVGMKM 1038

  Fly   399 LKNRLIYKAPSGSYINDFDPNIDPSVLNEHATAAFRYFHSQIEGRLDLLSELRQVL--GSLTLSD 461
            |          |.| ..:|||::..:|||.||||||:.|:.|...|..|.|..:.:  |.:.|..
Frog  1039 L----------GEY-KSYDPNVNAGILNEFATAAFRFGHTLINPILYRLDEKFEPIPQGHVPLHR 1092

  Fly   462 WFNRPGIIEVGDNFDSLTRG--HATQPEELTDINFDRQIKHFLFRRNMPFGSDLRSLDIQRNRDH 524
            .|..|..|......|.|.||  .......:|....:.::...||........||.:|::||.|||
Frog  1093 AFFSPFRIVNEGGIDPLLRGLIGVAAKMRVTSQLLNTELTEKLFSMAHAVALDLAALNVQRGRDH 1157

  Fly   525 GLASYNDMREFCGLRRAHSWEGY-GDLISPPILEKLKSLYPSHEDVDLTVGASLEAHVAGALAGP 588
            |:..|:|.|.||.|....:::.. .::.:|.:.||||.||.|..::||.....:|..:.|:..||
Frog  1158 GIPPYHDFRVFCNLSTVQTFDDLRNEIKNPDVREKLKRLYGSPLNIDLFPALMVEDLIPGSRLGP 1222

  Fly   589 TFLCILTEQFYRTRVGDRFFFENGDKLTGFTPDQLEELRKASMARLLCDNGNHISSMQPEAFRTV 653
            |.:|:||.||...|.||||::||...   ||..||.::::.|:||:|||||::|:.:|.:.||..
Frog  1223 TLMCLLTTQFRNIRDGDRFWYENPGV---FTAAQLTQIKQTSLARVLCDNGDNITKVQHDLFRVA 1284

  Fly   654 SHSNPIIPCSNIPQVDLTKWID 675
            ...:..:.|.||.::||..|.|
Frog  1285 EFPHGYVSCKNIAKMDLRVWQD 1306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pxd	NP_001163633.1	An_peroxidase	105..643	CDD:281139	199/567 (35%)
Pxd	NP_001163633.1	peroxinectin_like	260..638	CDD:188655	140/390 (36%)
pxdn	NP_001076815.1	leucine-rich repeat	38..56	CDD:275380
		LRR	<54..235	CDD:227223
		leucine-rich repeat	57..80	CDD:275380
		LRR_8	104..163	CDD:338972
		leucine-rich repeat	105..128	CDD:275378
		leucine-rich repeat	129..152	CDD:275378
		leucine-rich repeat	153..176	CDD:275378
		leucine-rich repeat	177..189	CDD:275378
		I-set	239..326	CDD:369462
		I-set	335..422	CDD:369462
		Ig3_Peroxidasin	439..512	CDD:143222
		Ig4_Peroxidasin	535..603	CDD:143223
		peroxidasin_like	856..1295	CDD:188658	158/456 (35%)
		VWC	1402..1452	CDD:214564
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	1	1.000	-	-		FOG0000202
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920