Protein Alignment Pxd and LPO

DIOPT Version :10

• Sequence 1: NP_996223.1
• Gene: Pxd / 2768671
• FlyBaseID: FBgn0004577
• Length: 690
• Species: Drosophila melanogaster
• Sequence 2: NP_006142.1
• Gene: LPO / 4025
• HGNCID: 6678
• Length: 712
• Species: Homo sapiens
• Alignment Length: 624
• Identity: 207/624 - (33%)
• Similarity: 310/624 - (49%)
• Gaps: 70/624 - (11%)

  Fly    91 VSCAAPPAV--CEK-TAYRTLDGSCNHLEQPGLGVANSKYGRLLTPKYADGISAP-------TRS 145
            |.|.||..|  |:. :.|||:.|.||:..:|.||.||....|.|..:|.||:|.|       ||:
Human   121 VGCGAPAPVVRCDPCSPYRTITGDCNNRRKPALGAANRALARWLPAEYEDGLSLPFGWTPGKTRN 185

  Fly   146 VTGDELPSARLVS--LVAF-GEQDVPDPEFTLHNMQWGQIMTHDMSM----QAGGTQSKKHPTRC 203
              |..||.||.||  :|.: .|:.|.|...:|..||||||:.||:..    :.|.::..|  .:|
Human   186 --GFPLPLAREVSNKIVGYLNEEGVLDQNRSLLFMQWGQIVDHDLDFAPDTELGSSEYSK--AQC 246

  Fly   204 CTDDGRLIGLDTAHKTCFAIIVPPHDPAYSQVGTE--CLNFVRTLTDRDSNC---QYQGGPAEQL 263
              |:..:.|     ..||.|:.||:||   :.||:  |:.|.|.    ...|   .|:....||:
Human   247 --DEYCIQG-----DNCFPIMFPPNDP---KAGTQGKCMPFFRA----GFVCPTPPYKSLAREQI 297

  Fly   264 TVVTSYLDLSLVYGNSIQQNSDIREFQG--GRMIVEER---NGAKWLPLSRNVTGDCDAVD--AS 321
            ..:||:||.|.||.:.....|.:|....  |.|.|.:.   :|..:||........|:.::  |.
Human   298 NALTSFLDASFVYSSEPSLASRLRNLSSPLGLMAVNQEVSDHGLPYLPYDSKKPSPCEFINTTAR 362

  Fly   322 EVCYRSGDVRVNQNPGLAILQTILLREHNRIADALSALNPHYDDRTLFQEARKINIAQYQQISYY 386
            ..|:.:||.|.:::..||...|:.||||||:|..|..|||.:|...|:||||||..|..|.|::.
Human   363 VPCFLAGDSRASEHILLATSHTLFLREHNRLARELKRLNPQWDGEKLYQEARKILGAFVQIITFR 427

  Fly   387 EWLPIFLGGENMLKNRLIYKAPSGSYINDFDPNIDPSVLNEHATAAFRYFHSQIEGRLDLLSELR 451
            ::|||.| |::|.|    :..|...|....||.|     :...|.|||:.|.::...:..|.|..
Human   428 DYLPILL-GDHMQK----WIPPYQGYSESVDPRI-----SNVFTFAFRFGHLEVPSSMFRLDENY 482

  Fly   452 QVLG---SLTLSD-WFNRPGIIEVGDNFDSLTRGHATQPEELTDIN--FDRQIKHFLFR-RNMPF 509
            |..|   .|.|.. :||...:::.| ..|.|.||...:..:|...|  ...::::.||: .:...
Human   483 QPWGPEPELPLHTLFFNTWRMVKDG-GIDPLVRGLLAKKSKLMKQNKMMTGELRNKLFQPTHRIH 546

  Fly   510 GSDLRSLDIQRNRDHGLASYNDMREFCGLRRAHSWEGYGDLISPPIL-EKLKSLYPSHEDVDLTV 573
            |.||.:::.||.||||...||..|.||.|.:..:.|....::...:| :||..||.:.:::|:.:
Human   547 GFDLAAINTQRCRDHGQPGYNSWRAFCDLSQPQTLEELNTVLKSKMLAKKLLGLYGTPDNIDIWI 611

  Fly   574 GASLEAHVAGALAGPTFLCILTEQFYRTRVGDRFFFENGDKLTGFTPDQLEELRKASMARLLCDN 638
            ||..|..|.....||...|:|.:||.:.|.||||::||...   ||.:|.:.|:|.|.:||:|||
Human   612 GAIAEPLVERGRVGPLLACLLGKQFQQIRDGDRFWWENPGV---FTNEQKDSLQKMSFSRLVCDN 673

  Fly   639 GNHISSMQPEAFRTVSHSNPIIPCSNIPQVDLTKWIDQK 677
             ..|:.:..:.|...|:....:.||.|.::||:.|...|
Human   674 -TRITKVPRDPFWANSYPYDFVDCSAIDKLDLSPWASVK 711

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pxd	NP_996223.1	An_peroxidase	105..650	CDD:460804	192/578 (33%)
LPO	NP_006142.1	myeloperoxidase_like	283..694	CDD:188656	137/425 (32%)