DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pxd and Igsf9b

DIOPT Version :9

Sequence 1:	NP_001163633.1	Gene:	Pxd / 2768671	FlyBaseID:	FBgn0004577	Length:	690	Species:	Drosophila melanogaster
Sequence 2:	NP_001363879.1	Gene:	Igsf9b / 315510	RGDID:	1564717	Length:	1441	Species:	Rattus norvegicus

Alignment Length:	479	Identity:	101/479 - (21%)
Similarity:	151/479 - (31%)	Gaps:	111/479 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 GSAPYVIGNSLPTSPA---------PQNPFSSPASP----PVSAYGYSFPTAGRVSC---AAPPA 98
            |....|..|||..||:         |....:.|  |    ||..:||       :.|   |.|||
  Rat   299 GKYTCVPSNSLGRSPSASAYLTVQYPARVLNMP--PVIYVPVGIHGY-------IRCPVDAEPPA 354

  Fly    99 V------------CEKTAYRTL--DGSCNHLE--QPGLGVANS-KYGRLLTPKYADGISAPTRSV 146
            .            .||....||  |||....|  :..||.... .|..|.|.    |.|||.|.|
  Rat   355 TVVKWNKDGRPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTM----GQSAPARLV 415

  Fly   147 TGD--------------ELPSARLVSLVAFGEQDVPDPEFTLHNMQWGQIMTHDM----SMQAGG 193
            ..|              |.....|:...|.|:   |.|..|...:.......|:.    |:|...
  Rat   416 LKDPPYFTVLPGWEYRQEAGRELLIPCAAAGD---PFPVITWRKVGKPSRSKHNALPSGSLQFRA 477

  Fly   194 TQSKKHPTRCCTDDGRLIGLDTAHKTCFAIIVPPHDPAYSQVGTECLNFVRTLTDRDSNCQYQGG 258
            ...:.|....|.....:..: ||......|...||.|     |:..::...|..:......|.||
  Rat   478 LSKEDHGEWECVATNVVTSI-TASTHLTVIGTSPHAP-----GSVRVHVSMTTANVSWEPGYDGG 536

  Fly   259 PAEQLTVVTSYLDLSLVYGNSIQQNSDIREFQGGRMIVEERNGAKWLPLSRNVTGDCDAVDA--S 321
            ..:..:|                       :.|..|...:.....||.||..:......||:  .
  Rat   537 YEQTFSV-----------------------WYGPLMKRAQFGPHDWLSLSVPLGPSWLLVDSLEP 578

  Fly   322 EVCYRSGDVRVNQNPGLAILQTILLREHNRIADALSALNPHYDDRTLFQEARKINIAQYQQISYY 386
            |..|:...:..|:....|..:.:.:   |.:|..::...|    ..|....|.:...:.||....
  Rat   579 ETAYQFSVLAQNRLGTSAFSEVVTV---NTLAFPVTTPEP----LVLVTPPRCLTANRTQQGVLL 636

  Fly   387 EWLPIFLGGENMLKNRLIYKAPSG---SYINDFDPNIDPSVLNEHATAAFRYFHSQIEGRLDLLS 448
            .|||  ....:...:|.|.:...|   ..::|..|..|.....:..:....|....:....||:|
  Rat   637 SWLP--PANHSFPIDRYIMEFRVGERWEMLDDAIPGTDGEFFAKDLSQDTWYEFRVLAVMQDLIS 699

  Fly   449 ELRQVLGSLTLSDWFNRPGIIEVG 472
            |...:.| ::.:|.|.:|.:.:.|
  Rat   700 EPSNIAG-VSSTDIFPQPDLTDDG 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pxd	NP_001163633.1	An_peroxidase	105..643	CDD:281139	80/396 (20%)
Pxd	NP_001163633.1	peroxinectin_like	260..638	CDD:188655	39/218 (18%)
Igsf9b	NP_001363879.1	PHA03247	<898..1246	CDD:223021
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	918..1044
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1111..1332
		Ig	41..115	CDD:319273
		I-set	139..225	CDD:369462
		Ig	229..321	CDD:386229	7/21 (33%)
		Ig	<353..414	CDD:386229	19/64 (30%)
		Ig	438..502	CDD:319273	13/67 (19%)
		FN3	510..605	CDD:238020	21/125 (17%)
		FN3	621..703	CDD:238020	17/83 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	762..821
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900