DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pxd and Epx

DIOPT Version :9

Sequence 1:	NP_001163633.1	Gene:	Pxd / 2768671	FlyBaseID:	FBgn0004577	Length:	690	Species:	Drosophila melanogaster
Sequence 2:	NP_001100507.1	Gene:	Epx / 303414	RGDID:	1311882	Length:	715	Species:	Rattus norvegicus

Alignment Length:	718	Identity:	214/718 - (29%)
Similarity:	322/718 - (44%)	Gaps:	136/718 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIRARDLLLLALLGFISSALGLKVSSGYHIVHNQPQSSFPNYHGFSYLQGSAPYVIGNSLPTSPA 65
            :::|.|.:.:| ||.:...|             |||.|.|                .|.......
  Rat    86 VVQAADYMHVA-LGLLEEKL-------------QPQESRP----------------FNVTDVLTE 120

  Fly    66 PQNPFSSPASPPVSAYGYSFPTAGRVSCAAPPAVCEKTA--YRTLDGSCNHLEQPGLGVANSKYG 128
            ||....|.||                .||....| ||.:  |||:.|.||:..:|.||.:|....
  Rat   121 PQLRLLSQAS----------------GCALQDQV-EKCSNKYRTITGRCNNRRRPWLGASNQALA 168

  Fly   129 RLLTPKYADGIS-----APTRSVTGDELPSARLVS--LVAFGEQDV-PDPEFTLHNMQWGQIMTH 185
            |.|..:|.|..|     .|.:...|..||..|.||  :|.|..:.: .|...:|..|||||.:.|
  Rat   169 RWLPAEYEDHRSLPFGWTPGKRRNGFLLPLVRAVSNQIVRFPSKKLTSDQGRSLMFMQWGQFIDH 233

  Fly   186 DMSMQAGGTQSKKHPTRCCTDDGRLIGLDTAHKT------CFAIIVPPHDPAY-SQVGTECLNFV 243
            |:..      :.:.|.|...:    :|:| ..||      ||.|.:||:||.. ||  .:|:.|.
  Rat   234 DLDF------TPESPARVTFN----MGVD-CEKTCAQLPPCFPIKIPPNDPRIKSQ--RDCIPFF 285

  Fly   244 RTLTDRDSNCQYQGGPAEQLTVVTSYLDLSLVYGNSIQQNSDIR-------------EFQGGRMI 295
            |:......|   :.....|:..:||::|.|:|||:.:.....:|             :||.
  Rat   286 RSAPACPQN---RNKVRNQINSLTSFVDASMVYGSEVSLALRLRNRTNYLGLLATNQQFQD---- 343

  Fly   296 VEERNGAKWLPLSRNVTGDCDAVD--ASEVCYRSGDVRVNQNPGLAILQTILLREHNRIADALSA 358
                ||...||........|...:  ....|:.:||.|.::.|.||.|.|:.:|||||:|..|..
  Rat   344 ----NGRALLPFDNLHEDPCLLTNRLVRIPCFLAGDSRASETPKLAALHTLFVREHNRLATELKR 404

  Fly   359 LNPHYDDRTLFQEARKINIAQYQQISYYEWLPIFLGGENMLKNRLIYKAPSGSYINDFDPNIDPS 423
            ||||:....|:.|||||..|..|.|:|.::||:.||...|.:....|:.        :..|:||.
  Rat   405 LNPHWSGDKLYNEARKIVGAMVQIITYRDFLPLVLGKARMRRTLGPYRG--------YCSNVDPR 461

  Fly   424 VLNEHATAAFRYFHSQIEG---RLDLLSELRQ-------VLGSLTLSDWFNRPGIIEVGDNFDSL 478
            |.|.. |.|||:.|:.::.   |||  |:.|.       :|.|...:.|    .|:..| ..|.:
  Rat   462 VANVF-TLAFRFGHTMLQPFMFRLD--SQYRTSAPNSHVLLSSAFFASW----RIVYEG-GIDPI 518

  Fly   479 TRGHATQPEELT--DINFDRQIKHFLFRRNMPFGSDLRSLDIQRNRDHGLASYNDMREFCGLRRA 541
            .||....|.:|.  |.....:::..||::....|.||.:|::||:|||||..||..|.||||.:.
  Rat   519 LRGLMATPAKLNRQDSMLVDELRDKLFQQVRRIGLDLAALNMQRSRDHGLPGYNAWRRFCGLSQP 583

  Fly   542 HSWEGYGDLI-SPPILEKLKSLYPSHEDVDLTVGASLEAHVAGALAGPTFLCILTEQFYRTRVGD 605
            .:......:: :..:..|..:||.:.:::|:.|||..|..:.||..||...|:...||.|.|.||
  Rat   584 RNLAQLSRVLKNRNLARKFLNLYKTPDNIDIWVGAIAEPLLPGARVGPLLACLFENQFRRARDGD 648

  Fly   606 RFFFENGDKLTGFTPDQLEELRKASMARLLCDNGNHISSMQPEAFRTVSHSNPIIPCSNIPQVDL 670
            ||:::   |...||..|.:.||:.|::|::||| ..||::..:.||...:....:.||.||:::|
  Rat   649 RFWWQ---KWGVFTKRQRKALRRISLSRIVCDN-TGISTVSRDIFRANIYPQGFVSCSRIPKLNL 709

  Fly   671 TKW 673
            :.|
  Rat   710 SAW 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pxd	NP_001163633.1	An_peroxidase	105..643	CDD:281139	182/580 (31%)
Pxd	NP_001163633.1	peroxinectin_like	260..638	CDD:188655	128/405 (32%)
Epx	NP_001100507.1	An_peroxidase	145..679	CDD:281139	182/577 (32%)
Epx	NP_001100507.1	myeloperoxidase_like	287..699	CDD:188656	135/442 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343969
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	1	1.000	-	-		FOG0000202
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.750