DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pxd and Lpo

DIOPT Version :9

Sequence 1:	NP_001163633.1	Gene:	Pxd / 2768671	FlyBaseID:	FBgn0004577	Length:	690	Species:	Drosophila melanogaster
Sequence 2:	XP_006247147.1	Gene:	Lpo / 287610	RGDID:	1310051	Length:	710	Species:	Rattus norvegicus

Alignment Length:	617	Identity:	212/617 - (34%)
Similarity:	312/617 - (50%)	Gaps:	62/617 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 RVSCAAP-PAV-CE-KTAYRTLDGSCNHLEQPGLGVANSKYGRLLTPKYADGISAP-------TR 144
            :|.|..| ||| |. ...|||:.|.||:.:.|.||.||....|.|..:|.||:|.|       ||
  Rat   118 KVGCNPPAPAVTCNISNPYRTITGDCNNRKNPALGSANRALARWLPAEYEDGLSLPFGWTPGKTR 182

  Fly   145 SVTGDELPSARLVSLVAFG---EQDVPDPEFTLHNMQWGQIMTHDMSMQAGGTQSKKHPTRCCTD 206
            :  |..||..|.||....|   |:||.|.:.::..||||||:.||:...........:.|:...|
  Rat   183 N--GYPLPQPREVSNQIAGYLNEEDVLDQKRSVLFMQWGQIVDHDLDFAPDTEMGTDNYTKAQCD 245

  Fly   207 DGRLIGLDTAHKTCFAIIVPPHDPAYSQVGTECLNFVRTLTDRDSNC---QYQGGPAEQLTVVTS 268
            :..:.|     ..||.|:.|..||.....| :|::|.|.    ...|   .||....||:..:||
  Rat   246 EHCIQG-----DNCFPIMFPTGDPKLKTQG-KCMSFFRA----GFVCPTPPYQSLTREQINALTS 300

  Fly   269 YLDLSLVYGNSIQQNSDIREFQG--GRMIVEER---NGAKWLPLSRNVTGDCDAVDASE--VCYR 326
            :||.||||.......:.:|....  |.|.|.|.   :|..:.|..:.....|:.::|:.  .|:.
  Rat   301 FLDASLVYSPEPSMANRLRNLSSPLGLMAVNEEVSDHGRPFPPFVKMKPSPCEVINATAGVPCFL 365

  Fly   327 SGDVRVNQNPGLAILQTILLREHNRIADALSALNPHYDDRTLFQEARKINIAQYQQISYYEWLPI 391
            :||.|.::...||...|:.:|||||:|..||.||||:|..||:||.|||..|..|.|::.::|||
  Rat   366 AGDSRASEQILLATSHTLFIREHNRLARELSTLNPHWDGETLYQETRKIMGAFIQIITFRDYLPI 430

  Fly   392 FLGGENMLKNRLIYKAPSGSYINDFDPNIDPSVLNEHATAAFRYFHSQIEGRLDLLSELRQVLGS 456
            .||.| |.|    :..|...|    :.::||.:.|.. |.|||:.|.:|...:..|.|..|..||
  Rat   431 LLGDE-MQK----WIPPYQGY----NESVDPRISNVF-TFAFRFGHLEIPSTVSRLDENYQPWGS 485

  Fly   457 ---LTL-SDWFNRPGIIEVGDNFDSLTRGHATQPEELTDINFDR----QIKHFLFR-RNMPFGSD 512
               |.| :.:||...:::.| ..|.|.||...:..:|  ::.||    ::::.||: .:...|.|
  Rat   486 EPELPLHTVFFNTWRLVKDG-GIDPLVRGLLAKKAKL--MHQDRMMTGELRNKLFQPTHTIHGFD 547

  Fly   513 LRSLDIQRNRDHGLASYNDMREFCGLRRAHSWEGYGDLISPPIL-EKLKSLYPSHEDVDLTVGAS 576
            |.|::|||.||||:..||..|.||||.:..:.|....::...:| :||..||.:..::|:.:||.
  Rat   548 LASINIQRCRDHGMPGYNSWRAFCGLSQPKTLEELSAVMENEVLAKKLLDLYGTPSNIDIWLGAI 612

  Fly   577 LEAHVAGALAGPTFLCILTEQFYRTRVGDRFFFENGDKLTGFTPDQLEELRKASMARLLCDNGNH 641
            .|..|.|...||...|:|..||.|.|.||||::||...   ||..|.|.|:|.|.:||:||| ..
  Rat   613 AEPLVPGGRVGPLLTCLLGHQFQRVRDGDRFWWENPGV---FTEKQRESLQKLSFSRLVCDN-TG 673

  Fly   642 ISSMQPEAFRTVSHSNPIIPCSNIPQVDLTKW 673
            |:.:....|...::.:..:.||::.::||:.|
  Rat   674 ITKVPLNPFLANTYPHGFVDCSSVDKLDLSPW 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pxd	NP_001163633.1	An_peroxidase	105..643	CDD:281139	198/567 (35%)
Pxd	NP_001163633.1	peroxinectin_like	260..638	CDD:188655	141/394 (36%)
Lpo	XP_006247147.1	An_peroxidase	136..675	CDD:281139	198/567 (35%)
Lpo	XP_006247147.1	myeloperoxidase_like	281..692	CDD:188656	148/427 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343971
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	1	1.000	-	-		FOG0000202
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.750