DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pxd and Tpo

DIOPT Version :9

Sequence 1:	NP_001163633.1	Gene:	Pxd / 2768671	FlyBaseID:	FBgn0004577	Length:	690	Species:	Drosophila melanogaster
Sequence 2:	XP_011242158.1	Gene:	Tpo / 22018	MGIID:	98813	Length:	915	Species:	Mus musculus

Alignment Length:	744	Identity:	212/744 - (28%)
Similarity:	329/744 - (44%)	Gaps:	117/744 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIRARDLLL-LALLGFISSALGLKVSSGYHIVHNQPQSSFPNYHGFSYLQ--------------- 49
            ::|:||:|. ..:...:.||:........|.|:|..:.:.......|..|
Mouse    23 ILRSRDILCGKTMKSHVISAVETSQLMVDHAVYNTMKRNLKKREVLSPAQLLSFFKLPESTSGAI 87

  Fly    50 GSAPYVIGNSLPTSPAPQNPFSSPASPPVSA--YGYSFPTAGRVSCAAPPA---VCEKTAYRTLD 109
            ..|..::..|:......|:.||:.|   :||  .|.....:|.:....||.   .|....||.:.
Mouse    88 SRAAEIMETSIQVMKREQSQFSTDA---LSADILGTIANLSGCLPFMLPPRCPDTCLANKYRPIT 149

  Fly   110 GSCNHLEQPGLGVANSKYGRLLTPKYADGISA-----PTRSVTGDELPSARLVS--LVAFGEQDV 167
            |:||:.:.|..|.:|:...|.|.|.|.||.|.     |.....|..||..|.|:  |:....:.|
Mouse   150 GACNNRDHPRWGASNTALARWLPPVYEDGFSQPKGWNPNFLYHGFPLPPVREVTRHLIQVSNEAV 214

  Fly   168 -PDPEFTLHNMQWGQIMTHDMSM--QAGGTQSKKHPTRC---CTDDGRLIGLDTAHKTCFAIIVP 226
             .|.:::.....|||.:.||:::  |:..|.:......|   |.:          ...||.|.:|
Mouse   215 TEDDQYSDFLPVWGQYIDHDIALTPQSTSTAAFWGGVDCQLTCEN----------QNPCFPIQLP 269

  Fly   227 PHDPAYSQVGTECLNFVRTLTDRDSNCQ-------YQGGPAEQLTVVTSYLDLSLVYGNSIQQNS 284
            .:    |...|.||.|.|:.....:..|       ....|.:|:..:||:||.|.|||:|.....
Mouse   270 SN----SSGTTACLPFYRSSAACGTGDQGALFGNLSAANPRQQMNGLTSFLDASTVYGSSPGVEK 330

  Fly   285 DIREFQGGRMIVEERN-----GAKWLPLSRNVTGDCDAVDASE---------VCYRSGDVRVNQN 335
            .:|.:.....::....     |..:||.:   |..|    |.|         .|:.:||.|.::.
Mouse   331 QLRNWSSSAGLLRVNTLHLDAGRAYLPFA---TAAC----APEPGTPRTNRTPCFLAGDGRASEV 388

  Fly   336 PGLAILQTILLREHNRIADALSALNPHYDDRTLFQEARKINIAQYQQISYYEWLPIFLGGENMLK 400
            |.||.:.|:.||||||:|.|..|:|.|:...|.:|||||:..|.:|.|:..:::|..||.:
Mouse   389 PALAAVHTLWLREHNRLASAFKAINKHWSANTAYQEARKVVGALHQIITMRDYIPKILGPD---- 449

  Fly   401 NRLIYKAPSGSYINDFDPNIDPSVLNEHATAAFRYFHSQIE---GRLDLLSELRQVLGSLTLSDW 462
               .::...|.| ..::|.::|:|.|..:|||||:.|:.:.   .||:...:....|..|.|.|.
Mouse   450 ---AFRQYVGPY-EGYNPTVNPTVSNIFSTAAFRFGHATVHPLVRRLNTDFQEHTELPRLQLRDV 510

  Fly   463 FNRP-GIIEVGDNFDSLTRGHATQP-----------EELTDINFDRQIKHFLFRRNMPFGSDLRS 515
            |.|| .:|:.| ..|.:.||...:.           ||||:         .||..:.....||.|
Mouse   511 FFRPWRLIQEG-GLDPIVRGLLARAAKLQVQGQLMNEELTE---------RLFVLSNVGTLDLAS 565

  Fly   516 LDIQRNRDHGLASYNDMREFCGLRRAHSWEGYGDLI-SPPILEKLKSLYPSHEDVDLTVGASLEA 579
            |::||.|||||..||:.||||||.|..:.......| :..::.|:..||...:::|:.:|...|.
Mouse   566 LNLQRGRDHGLPDYNEWREFCGLSRLETPAELNKAIANRSMVNKIMDLYKHADNIDVWLGGLAEK 630

  Fly   580 HVAGALAGPTFLCILTEQFYRTRVGDRFFFENGDKLTGFTPDQLEELRKASMARLLCDNGNHISS 644
            .:.||..||.|.||:.:|....|.||||::||.:.   ||..|.:||.|.|:.|::||| ..::.
Mouse   631 FLPGARTGPLFACIIGKQMKALRDGDRFWWENTNV---FTDAQRQELEKHSLPRVICDN-TGLTR 691

  Fly   645 MQPEAFRTVSHSNPIIPCSNIPQVDLTKW 673
            :..:|||..........|.:||.:||..|
Mouse   692 VPVDAFRIGKFPQDFESCEDIPSMDLELW 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pxd	NP_001163633.1	An_peroxidase	105..643	CDD:281139	179/587 (30%)
Pxd	NP_001163633.1	peroxinectin_like	260..638	CDD:188655	132/407 (32%)
Tpo	XP_011242158.1	thyroid_peroxidase	161..722	CDD:188657	182/603 (30%)
		CCP	730..783	CDD:153056
		EGF_CA	784..826	CDD:311536
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840099
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.750