Protein Alignment Pxd and Ptgs2

DIOPT Version :10

• Sequence 1: NP_996223.1
• Gene: Pxd / 2768671
• FlyBaseID: FBgn0004577
• Length: 690
• Species: Drosophila melanogaster
• Sequence 2: NP_035328.2
• Gene: Ptgs2 / 19225
• MGIID: 97798
• Length: 604
• Species: Mus musculus
• Alignment Length: 626
• Identity: 131/626 - (20%)
• Similarity: 209/626 - (33%)
• Gaps: 202/626 - (32%)

  Fly    95 APPAVCEKTAYRTLDGSCNHLEQPGLGVANSKYGRLLTPKYADGISAPTRSVTGDELP-SARLVS 158
            :||.......|::.:...|          .|.|.|.| |..||....|.......||| |..::.
Mouse   112 SPPTYNVHYGYKSWEAFSN----------LSYYTRAL-PPVADDCPTPMGVKGNKELPDSKEVLE 165

  Fly   159 LVAFGEQDVPDPEFTLHNMQ---WGQIMTHDMSMQAGGTQSKKHPTRCCTDDGRLIGLDTAHKTC 220
            .|....:.:|||:.:  ||.   :.|..||    |...|..|:.|
Mouse   166 KVLLRREFIPDPQGS--NMMFAFFAQHFTH----QFFKTDHKRGP-------------------- 204

  Fly   221 FAIIVPPHDPAYSQVGTECLNFVRTLTDRDSNCQYQGGPAEQLTVVTSYLDLSLVYGNSIQQNSD 285
                                .|.|.|...                    :||:.:||.::.:...
Mouse   205 --------------------GFTRGLGHG--------------------VDLNHIYGETLDRQHK 229

  Fly   286 IREFQGGRMIVEERNGAKWLPLSRNVTGDCDAVDASEVCY-----RSGDVRVNQN-----PGLAI 340
            :|.|:.|::..:...|..:.|..::.        ..|:.|     .:....|.|.     |||.:
Mouse   230 LRLFKDGKLKYQVIGGEVYPPTVKDT--------QVEMIYPPHIPENLQFAVGQEVFGLVPGLMM 286

  Fly   341 LQTILLREHNRIADALSALNPHYDDRTLFQEARKINIAQYQQISYYEWLPIFLGGENMLKNRLIY 405
            ..||.||||||:.|.|...:|.:.|..|||.:|.|.|.:..:|...:::....|....||
Mouse   287 YATIWLREHNRVCDILKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLK----- 346

  Fly   406 KAPSGSYINDFDPNIDPSVLNEHATAAFRYFHSQIEGRLDLLSELRQVLGSLTLSDWFN-RPGII 469
                      |||.:              .|:.|.:.:..:.||..      ||..|.. .|...
Mouse   347 ----------FDPEL--------------LFNQQFQYQNRIASEFN------TLYHWHPLLPDTF 381

  Fly   470 EVGD----------NFDSLTRGHATQPEELTDINFDRQIK-HFLFRRNMPFG-SDLRSLDIQRNR 522
            .:.|          |...|.....||..|    :|.|||. .....||:|.. ..:....|.::|
Mouse   382 NIEDQEYSFKQFLYNNSILLEHGLTQFVE----SFTRQIAGRVAGGRNVPIAVQAVAKASIDQSR 442

  Fly   523 DHGLASYNDMREFCGLRRAHSWE---GYGDLISPPILEKLKSLYPSHEDVDLTVGASLEAHVAGA 584
            :....|.|:.|:...|:...|:|   |..::.:     :||:||...:.::|.....:|.....|
Mouse   443 EMKYQSLNEYRKRFSLKPYTSFEELTGEKEMAA-----ELKALYSDIDVMELYPALLVEKPRPDA 502

  Fly   585 LAGPTFL--------------CILTEQFYRTRVGDRFFFENGDKLTGFTPDQLEELRKASMARLL 635
            :.|.|.:              .|.:.|:::.   ..|..|.|.|:          :..||:..|:
Mouse   503 IFGETMVELGAPFSLKGLMGNPICSPQYWKP---STFGGEVGFKI----------INTASIQSLI 554

  Fly   636 CDN-------GNHISSMQPEAFRTV----SHS-----NPII 660
            |:|       ..::...||....|:    |||     ||.:
Mouse   555 CNNVKGCPFTSFNVQDPQPTKTATINASASHSRLDDINPTV 595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pxd	NP_996223.1	An_peroxidase	105..650	CDD:460804	123/595 (21%)
Ptgs2	NP_035328.2	EGF_CA	19..55	CDD:238011
		prostaglandin_endoperoxide_synthase	75..562	CDD:188648	123/591 (21%)