DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pxd and skpo-1

DIOPT Version :9

Sequence 1:	NP_001163633.1	Gene:	Pxd / 2768671	FlyBaseID:	FBgn0004577	Length:	690	Species:	Drosophila melanogaster
Sequence 2:	NP_495768.1	Gene:	skpo-1 / 174340	WormBaseID:	WBGene00009897	Length:	655	Species:	Caenorhabditis elegans

Alignment Length:	668	Identity:	198/668 - (29%)
Similarity:	311/668 - (46%)	Gaps:	106/668 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 GFSYLQGSAPYVIGNSLPTSPA----------PQNPFSSP----ASPPVSAYGYSFPTAGRVS-- 92
            |...|....|......:||:..          |..|.|.|    :...|.|......::|:::
Worm    54 GTCSLTSPTPLTRQQDVPTARTFDDQQDRQFLPSRPSSIPEGCNSVMTVEAETRRIFSSGQLTAR 118

  Fly    93 -----CA----APPA---VCEKTAYRTLDGSCNHLEQPGLGVANSKYGRLLTPKYADG----ISA 141
                 ||    ||..   .|....||::||:||:|:.|..|.|.:.:.||:...|.||    :||
Worm   119 FRQQMCAEEQVAPDCSINQCFHKKYRSMDGTCNNLQNPVKGAAFTAFTRLMPAAYDDGFNTLVSA 183

  Fly   142 PTRSVTGDELPSARLVSL-VAFGEQDVPDPEFTLHNMQWGQIMTHDMSMQAGGTQSKKHPTRC-C 204
            ..|:     .|:.|.||: :...|:.:|....:| .|.:||.::||::..|.       ...| |
Worm   184 SRRN-----RPNPREVSVFLLSSERSLPGHVNSL-LMLFGQFVSHDITSNAA-------QNFCGC 235

  Fly   205 TDDGRLIGLDTAHKTCFAIIVPPHDPAYSQVGTECLNFVRTLTDRDSNCQYQGGPAEQLTVVTSY 269
            .:.|.:         |.:|..||.|.:     ..|:.|.|:.....:. |: |...|||.:.|:.
Worm   236 QNSGPM---------CASIFAPPSDRS-----RRCIPFTRSFPICGTG-QF-GRVREQLNMNTAA 284

  Fly   270 LDLSLVYGNSIQQNSDIREFQGGRMIVEERNGAKWLPLSRNVTGDCDAVDASEVCYRSGDVRVNQ 334
            :|.||:||:   :....|..:...|:.....|.:..|.:.| .|...|          ||.|...
Worm   285 IDASLIYGS---EAITARSLRFAAMLRTSMIGGRMFPPNTN-PGSLTA----------GDGRAIL 335

  Fly   335 NPGLAILQTILLREHNRIADALSALNPHYDDRTLFQEARKINIAQYQQISYYEWLPIFLGGENML 399
            ..|||.|.|..||.||.:|..|..:|.|::...:|||:|||.....|.|:|.|::|..:|..:
Worm   336 FVGLAALHTSFLRLHNNVAARLQNMNRHWNADRIFQESRKIVGGIVQVITYQEFVPELIGDAS-- 398

  Fly   400 KNRLIYKAPSGSYINDFDPNIDPSVLNEHATAAFRYFHSQIEGRLDLLSELRQVLGSLTLSDWFN 464
                  |...|:| |.::||::..||||.|..|:| .|..|:....|::...|.:......|..|
Worm   399 ------KTILGAY-NGYNPNVEIGVLNEFAAGAYR-LHGMIQETYPLVNSQFQEVNRYRFIDGVN 455

  Fly   465 RPGIIEVGDNFDSLTRGHAT----QPEELTDINFDRQIKHFLFRRNMPFGSDLRSLDIQRNRDHG 525
              .|..|.:|.|::.||..|    .|:.||....:|     ||..::    |:.:::|||.||||
Worm   456 --NINHVLNNIDAIYRGMMTVPVRSPQRLTTSVTER-----LFGGSV----DMAAVNIQRGRDHG 509

  Fly   526 LASYNDMREFCGLRRAHSWEGYGDLISPPILEKLKSLYPSHEDVDLTVGASLEAHVAGALAGPTF 590
            |.||||.|.||.||...|:..:.::....:.:::..||.:.:|:|..||..||...||:|.|.||
Worm   510 LRSYNDYRRFCNLRPITSFNDWPEVPDENVRQRIGQLYRTPDDLDFYVGGILEQPAAGSLLGATF 574

  Fly   591 LCILTEQFYRTRVGDRFFFENGDKLTGFTPDQLEELRKASMARLLCDNGNHISSMQPEAFRTVSH 655
            .|::.:||.|.|.||||::||...   ||..||.||::.:::.:||..|:::..:...|| .:.:
Worm   575 ACVIGKQFERLRDGDRFYYENPGV---FTSPQLAELKRTTLSWVLCQTGDNMVRVGRRAF-DIEN 635

  Fly   656 SNPIIPCSNIPQVDLTKW 673
            .:..:|||:|..::|..|
Worm   636 GSRAVPCSSITGLNLEAW 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pxd	NP_001163633.1	An_peroxidase	105..643	CDD:281139	173/547 (32%)
Pxd	NP_001163633.1	peroxinectin_like	260..638	CDD:188655	128/381 (34%)
skpo-1	NP_495768.1	ShKT	22..56	CDD:214586	1/1 (100%)
		An_peroxidase	143..623	CDD:281139	173/546 (32%)
		peroxinectin_like	275..619	CDD:188655	128/381 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49305
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	1	1.000	-	-		FOG0000202
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.830