DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pxd and Epx

DIOPT Version :9

Sequence 1:	NP_001163633.1	Gene:	Pxd / 2768671	FlyBaseID:	FBgn0004577	Length:	690	Species:	Drosophila melanogaster
Sequence 2:	NP_031972.2	Gene:	Epx / 13861	MGIID:	107569	Length:	716	Species:	Mus musculus

Alignment Length:	714	Identity:	212/714 - (29%)
Similarity:	317/714 - (44%)	Gaps:	128/714 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIRARDLLLLALLGFISSALGLKVSSGYHIVHNQPQSSFPNYHGFSYLQGSAPYVIGNSLPTSPA 65
            :::|.|.:.:| ||.:...|             ||             :||.|:   |:......
Mouse    87 VVQAADYMHVA-LGLLEERL-------------QP-------------RGSRPF---NATDVLTE 121

  Fly    66 PQNPFSSPASPPVSAYGYSFPTAGRVSCAAPPAV--CEKTAYRTLDGSCNHLEQPGLGVANSKYG 128
            ||....|.||                .||.....  | ...|||:.|.||:.:.|.||.:|....
Mouse   122 PQLRLLSQAS----------------GCALQDQAERC-SNKYRTITGRCNNKKHPWLGASNQALA 169

  Fly   129 RLLTPKYADGIS-----APTRSVTGDELPSARLVS--LVAFGEQDVPDPEFT------LHNMQWG 180
            |.|..:|.|..|     .|.:...|..||..|.||  :|.|     |..:.|      |..||||
Mouse   170 RWLPAEYEDHRSLPFGWTPGKRRNGFLLPLVRDVSNQIVRF-----PSKKLTSDRGRALMFMQWG 229

  Fly   181 QIMTHDMSMQAGGTQSKKHPTRCCTDDGRLIGLDTAHKT------CFAIIVPPHDPAYSQVGTEC 239
            |.:.||:..      |.:.|.|....    :|:| ..||      ||.|.:|.:||.... ..:|
Mouse   230 QFIDHDLDF------SPESPARVAFS----MGVD-CEKTCAQLPPCFPIKIPRNDPRIKN-QRDC 282

  Fly   240 LNFVRTLTDRDSNCQYQGGPAEQLTVVTSYLDLSLVYGNSIQQNSDIREFQG--GRMIVEER--- 299
            :.|.|:......|   :.....|:..:||::|.|:|||:.:.....:|....  |.:...:|
Mouse   283 IPFFRSAPACPQN---RNKVRNQINALTSFVDASMVYGSEVTLALRLRNRTNFLGLLATNQRFQD 344

  Fly   300 NGAKWLPLSRNVTGDCDAVDASE--VCYRSGDVRVNQNPGLAILQTILLREHNRIADALSALNPH 362
            ||...||........|...:.|.  .|:.:||.|.::.|.|..|.|:.:|||||:|..|..||||
Mouse   345 NGRALLPFDNLHEDPCLLTNRSARIPCFLAGDTRSSETPKLTALHTLFVREHNRLAAELRRLNPH 409

  Fly   363 YDDRTLFQEARKINIAQYQQISYYEWLPIFLGGENMLKNRLIYKAPSGSYINDFDPNIDPSVLNE 427
            :....|:.|||||..|..|.|:|.::||:.||       |...:...|.| ..:..|:||.|.|.
Mouse   410 WSGDKLYNEARKIVGAMVQIITYRDFLPLVLG-------RARIRRTLGPY-RGYCSNVDPRVANV 466

  Fly   428 HATAAFRYFHSQIEG---RLDLLSELRQ-------VLGSLTLSDWFNRPGIIEVGDNFDSLTRGH 482
            . |.|||:.|:.::.   |||  |:.|.       .|.|:..:.|    .||..| ..|.:.||.
Mouse   467 F-TLAFRFGHTMLQPFMFRLD--SQYRASAPNSHVPLSSVFFASW----RIIHEG-GIDPILRGL 523

  Fly   483 ATQPEELT--DINFDRQIKHFLFRRNMPFGSDLRSLDIQRNRDHGLASYNDMREFCGLRRAHSWE 545
            ...|.:|.  |.....:::..||::....|.||.:|::||:|||||..||..|.||||.:..:..
Mouse   524 MATPAKLNRQDSMLVDELRDKLFQQVRRIGLDLAALNMQRSRDHGLPGYNAWRRFCGLSQPRNLA 588

  Fly   546 GYGDLI-SPPILEKLKSLYPSHEDVDLTVGASLEAHVAGALAGPTFLCILTEQFYRTRVGDRFFF 609
            ....:: :..:..|...||.:.:::|:.|||..|..:.||..||...|:...||.|.|.||||::
Mouse   589 QLSRVLKNQDLARKFLRLYKTPDNIDIWVGAIAEPLLPGARVGPLLACLFENQFRRARDGDRFWW 653

  Fly   610 ENGDKLTGFTPDQLEELRKASMARLLCDNGNHISSMQPEAFRTVSHSNPIIPCSNIPQVDLTKW 673
            :   |...||..|.:.||:.|::|::||| ..|:::..:.||...:....:.||.||:::|:.|
Mouse   654 Q---KWGVFTKRQRKALRRISLSRIVCDN-TGITTVSRDIFRANIYPQGFVSCSRIPKLNLSAW 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pxd	NP_001163633.1	An_peroxidase	105..643	CDD:281139	183/576 (32%)
Pxd	NP_001163633.1	peroxinectin_like	260..638	CDD:188655	130/397 (33%)
Epx	NP_031972.2	An_peroxidase	146..684	CDD:281139	184/577 (32%)
Epx	NP_031972.2	myeloperoxidase_like	288..700	CDD:188656	136/434 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840095
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	1	1.000	-	-		FOG0000202
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.750