DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pxd and duox2

DIOPT Version :9

Sequence 1:	NP_001163633.1	Gene:	Pxd / 2768671	FlyBaseID:	FBgn0004577	Length:	690	Species:	Drosophila melanogaster
Sequence 2:	XP_017947900.2	Gene:	duox2 / 100486050	XenbaseID:	XB-GENE-6047411	Length:	1517	Species:	Xenopus tropicalis

Alignment Length:	579	Identity:	157/579 - (27%)
Similarity:	234/579 - (40%)	Gaps:	111/579 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 DGSCNHLEQPGLGVANSKYGRLLTPKYADGISAPTRSVTGDELPSARLVS-LVAFGEQDVPDP-E 171
            ||..|:|.....|...||..|.:...|.||:....:.   .|||:.|.:| :|..|:..:|.. .
Frog    30 DGWYNNLAYHSTGSPGSKLLRHIPAFYTDGVYQVPKE---PELPNPRSISNVVTKGKSGLPSSRN 91

  Fly   172 FTLHNMQWGQIMTHDMSMQAGGTQSKKHPTRCCTDDGRLIGLDTAHKTCFA----IIVPPHDPAY 232
            .|:..:.:|..:..::                         :.|....|.|    |.:|..|..:
Frog    92 LTVMAISFGYHVLSEV-------------------------VYTGKPACPAEFLNIEIPKGDLVF 131

  Fly   233 SQVGTE--CLNFVRTL----TDRDSNCQYQGGPAEQLTVVTSYLDLSLVYGNSIQQNSDIREFQG 291
            .:..|.  .:.|.|:.    |.|..|     .|.:.:..|::::|.|.:||:|......:|.|.|
Frog   132 DRTNTSKVVIPFQRSKWYPDTGRSPN-----NPRDHVNSVSAWIDGSSIYGSSHSWCDALRNFSG 191

  Fly   292 GRMIVEERNG----AKW-LPL------SRNVTGDCDAVDASEVCYRSGDVRVNQNPGLAILQTIL 345
            |::......|    ||. ||:      |...||       :...|..|:.|.|::|.|..|..:.
Frog   192 GKLASGPDEGVPRFAKSDLPMWKVPNPSTGETG-------NNGLYAFGNARANESPFLQSLGILW 249

  Fly   346 LREHNRIADALSALNPHYDDRTLFQEARKINIAQYQQISYYEWLPIFLGGENMLKNRLIYKAPSG 410
            .|.||..|...:..||.:.|..|||.|||..||.||.|.:|||||.||.     :|...||
Frog   250 FRYHNYKAQEFAKENPEWSDEVLFQHARKWVIAVYQNIVFYEWLPAFLS-----RNVTAYK---- 305

  Fly   411 SYINDFDPNIDPSVLNEHATAAFRYFHSQIEGRLDLLSELRQVLGS---------LTLSDWFNRP 466
            .|....||:|.|....:.:...:....|.|..| :.....:.|.||         |..:.|....
Frog   306 GYQQHVDPSISPVFTVQLSQMIYTMMPSGIYMR-NKDCNFQNVSGSNGSVWPALRLCNNYWNREN 369

  Fly   467 GIIEVGDNFDSLTRGHATQPEE---------LTDINFDRQIKHFLFRRNMPFGSDLRSLDIQRNR 522
            ..::...:.|.:..|.|:|..|         |||..:. |||:        ..:||.:..|...|
Frog   370 SNLKNSSSTDEILMGMASQIAEKEDNILVNDLTDYCYG-QIKY--------SRTDLFAASILHAR 425

  Fly   523 DHGLASYNDMREFCGLRRAHSWEGYGDLISPPILEKLKSLYPSH-EDVDLTVGASLEAHVAGALA 586
            |.||.:||.:.|:.......:||...|   ..:.:||.|||.:. |.::...|  |.|.:||...
Frog   426 DLGLPNYNKVCEYYQCPLLENWEKMTD---KELGKKLASLYGNDTEKLEFIPG--LLAEMAGNSI 485

  Fly   587 GPTFLCILTEQFYRTRVGDRFFFENGDKLTGFTPDQLEELRKASMARLL---CDNGNHI 642
            . .|..|:.|||||.|.||||:||| .|...|:...::.:|...:..:|   .|.|:.|
Frog   486 N-FFSDIVLEQFYRLRDGDRFWFEN-VKNGLFSKKDIDNIRNIKLQNVLVAVTDAGDTI 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pxd	NP_001163633.1	An_peroxidase	105..643	CDD:281139	157/579 (27%)
Pxd	NP_001163633.1	peroxinectin_like	260..638	CDD:188655	120/410 (29%)
duox2	XP_017947900.2	dual_peroxidase_like	29..581	CDD:188652	157/579 (27%)
		FRQ1	726..918	CDD:227455
		PLN02292	1056..>1376	CDD:215165
		NOX_Duox_like_FAD_NADP	1244..1517	CDD:99783
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910