DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pxd and tpo

DIOPT Version :9

Sequence 1:	NP_001163633.1	Gene:	Pxd / 2768671	FlyBaseID:	FBgn0004577	Length:	690	Species:	Drosophila melanogaster
Sequence 2:	XP_031758614.1	Gene:	tpo / 100036738	XenbaseID:	XB-GENE-920152	Length:	872	Species:	Xenopus tropicalis

Alignment Length:	691	Identity:	218/691 - (31%)
Similarity:	322/691 - (46%)	Gaps:	125/691 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 NSLPTSPAPQNPFSS--------PASPPVSAYGYSFPT--AGRVSCA----AP--PAVCEKTAYR 106
            :::|.|..|:|...:        |.|..||..|.||..  |....|.    :|  |..|....||
Frog    37 DNIPQSALPRNSSQTDKTSLEQHPESEDVSHTGSSFEAVLANLTGCVPQTLSPFCPNNCLAGKYR 101

  Fly   107 TLDGSCNHLEQPGLGVANSKYGRLLTPKYADGISAPTR-----SVTGDELPSARLV-------SL 159
            .:.|:||:...|..|.||:...|.|..:|.|||..|..     ...|..||..|.|       |.
Frog   102 HITGACNNRNNPAWGAANTLLARWLPAQYEDGIGEPKGWREEFLYNGFRLPQVREVTNKIIHASS 166

  Fly   160 VAFGEQDVPDPEFTLHNMQWGQIMTHDMSMQAGGTQS-KKHPTRCCTDDGRLIGLDTAHKT---- 219
            .||.|.|:    ::...::|||.:.||::..   .|| .|.|.         ||......|
Frog   167 KAFREDDL----YSHIIIEWGQYIDHDIAFT---PQSVSKTPA---------IGSVDCKSTCENL 215

  Fly   220 --CFAIIVPPHDPAYSQVGTECLNFVRTLTDRDSNC-QYQGG----------PAEQLTVVTSYLD 271
              |:.|.:...|| .||.|  |:.|.|:    .|.| ..:||          |.||:..:||::|
Frog   216 YPCYPIKLSEEDP-LSQGG--CIPFYRS----SSACGTGRGGLKFGNPSLLNPREQINGLTSFID 273

  Fly   272 LSLVYGN--SIQQNSDIREFQGGRMIVEER---NGAKWLPLS------RNVTGD-CDAVDASEVC 324
            .|.|||:  |:|........:.|.:.|..:   :..::||..      ::.|.| .:.:|    |
Frog   274 ASTVYGSSESLQHKLKNLSSEEGLLRVNVKYSDSSREYLPFETPSACMQDPTADNAERID----C 334

  Fly   325 YRSGDVRVNQNPGLAILQTILLREHNRIADALSALNPHYDDRTLFQEARKINIAQYQQISYYEWL 389
            :.:|:.|.|:...||.:.|:.||||||||.||..||||::..|.:||||||..|.:|.|::.:::
Frog   335 FFAGEGRANEVITLAAVHTLWLREHNRIAKALKKLNPHWNSETTYQEARKIVGALHQIITFRDYM 399

  Fly   390 PIFLGGENMLKNRLIYKAPSGSYI---NDFDPNIDPSVLNEHATAAFRYFHSQIEGRLDLLSELR 451
            |..||           ||....||   ..::...:||:.|...|||||:.|:.|...:..|:.
Frog   400 PKILG-----------KAAYDQYIGLYKGYNQKTNPSISNIFTTAAFRFGHATIPPMVHRLNS-- 451

  Fly   452 QVLG-----SLTLSDWFNRPGIIEVGDNFDSLTRG----HATQPEELTDINFDRQIKHFLFRRNM 507
            |.:.     ||.|::.|.||..|......|.|.||    .|....::..||.:...|..:...|
Frog   452 QYVDDPKYPSLPLNEVFFRPWRIVKEGGLDPLIRGLLGKSAKLQTQVDMINEELTEKLLVMTNN- 515

  Fly   508 PFGS-DLRSLDIQRNRDHGLASYNDMREFCGLRRAHSWEGYGDLIS----PPILEKLKSLYPSHE 567
              || ||.||::||.|||||..|||.||||||.|..:   ..|||:    ..::.|:.:||...:
Frog   516 --GSMDLASLNLQRGRDHGLPGYNDWREFCGLSRLAT---PADLINAVSDQKLVAKMIALYSHPD 575

  Fly   568 DVDLTVGASLEAHVAGALAGPTFLCILTEQFYRTRVGDRFFFENGDKLTGFTPDQLEELRKASMA 632
            ::|:.:|...|..:.||..||.|.|::.:|....|.||||::||.:.   ||..|..||.|.|::
Frog   576 NIDVWLGGLAEDFLPGARTGPLFACLIGKQMQALREGDRFWYENNNI---FTKIQRSELEKHSLS 637

  Fly   633 RLLCDNGNHISSMQPEAFRTVSHSNPIIPCSNIPQVDLTKW 673
            |::||| ..:|.:..:||...::.:..:.|.:||.::|..|
Frog   638 RVICDN-TGLSHVPLDAFLLGNYPDNFVSCDSIPGINLEAW 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pxd	NP_001163633.1	An_peroxidase	105..643	CDD:281139	194/596 (33%)
Pxd	NP_001163633.1	peroxinectin_like	260..638	CDD:188655	139/406 (34%)
tpo	XP_031758614.1	thyroid_peroxidase	116..679	CDD:188657	196/612 (32%)
		CCP	687..736	CDD:153056
		EGF_CA	738..781	CDD:214542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010