DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fer1 and MESP2

DIOPT Version :9

Sequence 1:	NP_001262334.1	Gene:	Fer1 / 2768661	FlyBaseID:	FBgn0037475	Length:	256	Species:	Drosophila melanogaster
Sequence 2:	NP_001035047.1	Gene:	MESP2 / 145873	HGNCID:	29659	Length:	397	Species:	Homo sapiens

Alignment Length:	231	Identity:	57/231 - (24%)
Similarity:	89/231 - (38%)	Gaps:	64/231 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 DAYSSGFNSDQENTEKTFCPF--SRRSHKPRRLKCASQMAQ----------------QRQAANLR 94
            |:.|...:||...:    ||.  :|...:|:...|:|:.|:                |||:|:.|
Human    29 DSTSPASSSDSSGS----CPCDGARGLPQPQPPSCSSRAAEAAATTPRRARTGPAGGQRQSASER 89

  Fly    95 ERRRMQSINEAFEGLRTHIP--TLPYEKRLSKVDTLKLAISYITFLSEMVKKDKNGNEPGLSLQR 157
            |:.||:::..|...||..:|  ..|..:.|:|::||:|||.||..||.::    ..:|..|..:|
Human    90 EKLRMRTLARALHELRRFLPPSLAPAGQSLTKIETLRLAIRYIGHLSAVL----GLSEESLQCRR 150

  Fly   158 NYQKEPPKKIILKDRTGGVAHSLSWYRKGDRYPGSKLYARTW-TPEDP-RGP-HSQPLPLYNNSN 219
            .                         ::||  .||     .| .|..| ||| .:|.........
Human   151 R-------------------------QRGD--AGS-----PWGCPLCPDRGPAEAQTQAEGQGQG 183

  Fly   220 SNQNQNSNQSSDDFSGSGADMS-DPGAAASIFSSGS 254
            ..|.|...|......|.|.... .||..:::.:..|
Human   184 QGQGQGQGQGQGQGQGQGQGQGRRPGLVSAVLAEAS 219

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fer1	NP_001262334.1	HLH	92..144	CDD:197674	20/53 (38%)
MESP2	NP_001035047.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..92		17/66 (26%)
		HLH	82..135	CDD:278439	22/52 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	152..208		16/62 (26%)
		13 X 2 AA tandem repeats of G-Q	179..204		5/24 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	222..295
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	351..376
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4029
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810