Protein Alignment GNA12 and Galphaq

DIOPT Version :9

• Sequence 1: NP_031379.2
• Gene: GNA12 / 2768
• HGNCID: 4380
• Length: 381
• Species: Homo sapiens
• Sequence 2: NP_725192.2
• Gene: Galphaq / 36384
• FlyBaseID: FBgn0004435
• Length: 396
• Species: Drosophila melanogaster
• Alignment Length: 414
• Identity: 152/414 - (36%)
• Similarity: 224/414 - (54%)
• Gaps: 65/414 - (15%)

Human    11 CLLPAEAGGARERRAGSGARDAEREARRRSRDIDALLARERRAVRRLVKILLLGAGESGKSTFLK 75
            |.|..||                :|.:|.:::|:..|.|::|..||.:|:||||.||||||||:|
  Fly     3 CCLSEEA----------------KEQKRINQEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIK 51

Human    76 QMRIIHGREFDQKALLEFRDTIFDNILKGSRVLVDARDKLGIPWQYSENEKHGMFLMAFENKAGL 140
            |||||||..:..:....:...:|.||....:.::.|.|.|.|.:...|:.:....:|:.:.:.
  Fly    52 QMRIIHGSGYSDEDKRGYIKLVFQNIFMAMQSMIKAMDMLKISYGQGEHSELADLVMSIDYET-- 114

Human   141 PVEPATFQ-LYVPALSALWRDSGIREAFSRRSEFQLGESVKYFLDNLDRIG-------------- 190
               ..||: .|:.|:..||.|:||:|.:.||.|:||.:|.||:|.:|||:.
  Fly   115 ---VTTFEDPYLNAIKTLWDDAGIQECYDRRREYQLTDSAKYYLKDLDRVAQPAYLPTEQDILRV 176

Human   191 -----------------------------QLNYFPSKQDILLARKATKGIVEHDFVIKKIPFKMV 226
                                         |.:|.|::||||.||..|.||:|:.|.:..|.|:||
  Fly   177 RVPTTGIIEYPFDLEEIRFSYLSDLARIEQADYLPTEQDILRARVPTTGILEYPFDLDGIVFRMV 241

Human   227 DVGGQRSQRQKWFQCFDGITSILFMVSSSEYDQVLMEDRRTNRLVESMNIFETIVNNKLFFNVSI 291
            |||||||:|:||..||:.:|||:|:|:.|||||:|.|....||:.||..:|.||:....|.|.|:
  Fly   242 DVGGQRSERRKWIHCFENVTSIIFLVALSEYDQILFESDNENRMEESKALFRTIITYPWFQNSSV 306

Human   292 ILFLNKMDLLVEKVKTVSIKKHFPDFRGDPHRLEDVQRYLVQCFDRKRRNRSKPLFHHFTTAIDT 356
            ||||||.|||.||:....:..:||::.|........:.::::.|.....:..|.::.|||.|.||
  Fly   307 ILFLNKKDLLEEKIMYSHLVDYFPEYDGPQRDAITAREFILRMFVDLNPDSEKIIYSHFTCATDT 371

Human   357 ENVRFVFHAVKDTILQENLKDIML 380
            ||::.||.||||||:|..||:..|
  Fly   372 ENIKLVFCAVKDTIMQNALKEFNL 395

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GNA12	NP_031379.2	G_alpha	42..379	CDD:214595	145/380 (38%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	59..72		10/12 (83%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	200..208		5/7 (71%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	223..232		7/8 (88%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	292..299		6/6 (100%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	351..356		2/4 (50%)
Galphaq	NP_725192.2	G-alpha	34..390	CDD:206639	137/360 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54330
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820