Protein Alignment GNA12 and Galphao

DIOPT Version :9

• Sequence 1: NP_031379.2
• Gene: GNA12 / 2768
• HGNCID: 4380
• Length: 381
• Species: Homo sapiens
• Sequence 2: NP_523684.2
• Gene: Galphao / 36104
• FlyBaseID: FBgn0001122
• Length: 354
• Species: Drosophila melanogaster
• Alignment Length: 345
• Identity: 152/345 - (44%)
• Similarity: 218/345 - (63%)
• Gaps: 5/345 - (1%)

Human    33 EREARRRSRDIDALLARERRAVRRLVKILLLGAGESGKSTFLKQMRIIHGREFDQKALLEFRDTI 97
            ||.|..|||.|:..|..:.....:.:|:||||||||||||.:|||:|||...|..:...::|..:
  Fly     9 ERAAAARSRLIERNLKEDGIQAAKDIKLLLLGAGESGKSTIVKQMKIIHESGFTAEDFKQYRPVV 73

Human    98 FDNILKGSRVLVDARDKLGIPWQYSENEKHGMFLMAFENKAGL-PVEPATFQLYVPALSALWRDS 161
            :.|.::....::.|...|.|  |||.||:.....|.|:....: ..||.:.:| :.|:..||:|:
  Fly    74 YSNTIQSLVAILRAMPTLSI--QYSNNERESDAKMVFDVCQRMHDTEPFSEEL-LAAMKRLWQDA 135

Human   162 GIREAFSRRSEFQLGESVKYFLDNLDRIGQLNYFPSKQDILLARKATKGIVEHDFVIKKIPFKMV 226
            |::|.|||.:|:||.:|.|||||:|||:|..:|.|::||||..|..|.||||..|..|.:.||:.
  Fly   136 GVQECFSRSNEYQLNDSAKYFLDDLDRLGAKDYQPTEQDILRTRVKTTGIVEVHFSFKNLNFKLF 200

Human   227 DVGGQRSQRQKWFQCFDGITSILFMVSSSEYDQVLMEDRRTNRLVESMNIFETIVNNKLFFNVSI 291
            |||||||:|:||..||:.:|:|:|.|:.|||||||.||..|||:.||:.:|::|.|||.|.:.||
  Fly   201 DVGGQRSERKKWIHCFEDVTAIIFCVAMSEYDQVLHEDETTNRMQESLKLFDSICNNKWFTDTSI 265

Human   292 ILFLNKMDLLVEKVKTVSIKKHFPDFRGDPHRLEDVQRYLVQCFDRKRRNRSKPLFHHFTTAIDT 356
            ||||||.||..||::...:...||::.|. ....:...|:...|:.|.::.||.::.|.|.|.||
  Fly   266 ILFLNKKDLFEEKIRKSPLTICFPEYTGG-QEYGEAAAYIQAQFEAKNKSTSKEIYCHMTCATDT 329

Human   357 ENVRFVFHAVKDTILQENLK 376
            .|::|||.||.|.|:..||:
  Fly   330 NNIQFVFDAVTDVIIANNLR 349

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GNA12	NP_031379.2	G_alpha	42..379	CDD:214595	146/336 (43%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	59..72		11/12 (92%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	200..208		4/7 (57%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	223..232		6/8 (75%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	292..299		6/6 (100%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	351..356		2/4 (50%)
Galphao	NP_523684.2	G-alpha	34..348	CDD:206639	142/317 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54330
OrthoDB	1	1.010	-	-		D754573at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.830