Protein Alignment GNA11 and Galphas

DIOPT Version :10

• Sequence 1: NP_002058.2
• Gene: GNA11 / 2767
• HGNCID: 4379
• Length: 359
• Species: Homo sapiens
• Sequence 2: NP_477505.1
• Gene: Galphas / 37805
• FlyBaseID: FBgn0001123
• Length: 385
• Species: Drosophila melanogaster
• Alignment Length: 372
• Identity: 147/372 - (39%)
• Similarity: 214/372 - (57%)
• Gaps: 26/372 - (6%)

Human    12 SDEVKESKRINAEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGAGYSEEDKRGFT 76
            |::.|..||.:..|.:||::||:..|...:|||||.|||||||.:|||||:|..|:|:.:|:...
  Fly    16 SEDSKSQKRRSDAISRQLQKDKQLYRATHRLLLLGAGESGKSTIVKQMRILHVDGFSDSEKKQKI 80

Human    77 KLVYQNIFTAMQAMIRAMETLK--ILYKYEQNKANALLIREVDVEKVTTFEHQYVSAIKTLWEDP 139
            ..:.:||..|:..:..||.||.  :..:.::|:.....|::........:..::....:.||:|.
  Fly    81 DDIKKNIRDAILTITGAMSTLNPPVALEKKENEPRVEYIQDYASSPDFNYPPEFYEHTEELWKDK 145

Human   140 GIQECYDRRREYQLSDSAKYYLTDVDRIATLGYLPTQQDVLRVRVPTTGIIEYPFDLENIIFRMV 204
            |:.:.|:|..||||.|.|||:|..|..|....|.|.:||:||.||.|:||.|..|.::.:.|.|.
  Fly   146 GVLQTYERSNEYQLIDCAKYFLDRVSTIKNPNYTPNEQDILRCRVLTSGIFETRFQVDKVNFHMF 210

Human   205 DVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRMEESKALFRTIITYPWFQNSSV 269
            ||||||.||||||.||.:||:|:|:.|.|.|:.||.|...:||:.||..||::|....|.:..|:
  Fly   211 DVGGQRDERRKWIQCFNDVTAIIFVTACSSYNMVLREDPTQNRLRESLDLFKSIWNNRWLRTISI 275

Human   270 ILFLNKKDLLEDKIL--YSHLVDYFPEF-----------------DGPQRDAQAAREFILKMFVD 315
            ||||||:|||.:||.  .|.|.:||.||                 |.|  :...|:.||...|:.
  Fly   276 ILFLNKQDLLAEKIKAGKSKLSEYFSEFNKYQTPIDTGDAIMESNDDP--EVIRAKYFIRDEFLR 338

Human   316 LNP---DSDKIIYSHFTCATDTENIRFVFAAVKDTILQLNLKEYNLV 359
            ::.   |.....|.|||||.|||||:.||...:|.|.:::|::|.|:
  Fly   339 ISTASGDGKHYCYPHFTCAVDTENIKRVFNDCRDIIQRMHLRQYELL 385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GNA11	NP_002058.2	G-alpha	40..353	CDD:206639	134/336 (40%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	41..54		10/12 (83%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	178..186		5/7 (71%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	201..210		6/8 (75%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	270..277		6/6 (100%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	329..334		3/4 (75%)
Galphas	NP_477505.1	G-alpha	44..379	CDD:206639	134/336 (40%)