Protein Alignment GNA11 and Galphaq

DIOPT Version :10

• Sequence 1: NP_002058.2
• Gene: GNA11 / 2767
• HGNCID: 4379
• Length: 359
• Species: Homo sapiens
• Sequence 2: NP_725192.2
• Gene: Galphaq / 36384
• FlyBaseID: FBgn0004435
• Length: 396
• Species: Drosophila melanogaster
• Alignment Length: 395
• Identity: 287/395 - (72%)
• Similarity: 318/395 - (80%)
• Gaps: 43/395 - (10%)

Human     7 MACCLSDEVKESKRINAEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGAGYSEED 71
            |.||||:|.||.||||.|||||||||||||||||||||||||||||||||||||||||:|||:||
  Fly     1 MECCLSEEAKEQKRINQEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDED 65

Human    72 KRGFTKLVYQNIFTAMQAMIRAMETLKILYKYEQNKANALLIREVDVEKVTTFEHQYVSAIKTLW 136
            |||:.|||:||||.|||:||:||:.|||.|...::...|.|:..:|.|.|||||..|::||||||
  Fly    66 KRGYIKLVFQNIFMAMQSMIKAMDMLKISYGQGEHSELADLVMSIDYETVTTFEDPYLNAIKTLW 130

Human   137 EDPGIQECYDRRREYQLSDSAKYYLTDVDRIATLGYLPTQQDVLRVRVPTTGIIEYPFDLE---- 197
            :|.||||||||||||||:|||||||.|:||:|...||||:||:||||||||||||||||||
  Fly   131 DDAGIQECYDRRREYQLTDSAKYYLKDLDRVAQPAYLPTEQDILRVRVPTTGIIEYPFDLEEIRF 195

Human   198 ---------------------------------------NIIFRMVDVGGQRSERRKWIHCFENV 223
                                                   .|:|||||||||||||||||||||||
  Fly   196 SYLSDLARIEQADYLPTEQDILRARVPTTGILEYPFDLDGIVFRMVDVGGQRSERRKWIHCFENV 260

Human   224 TSIMFLVALSEYDQVLVESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEDKILYSHL 288
            |||:||||||||||:|.||||||||||||||||||||||||||||||||||||||||:||:||||
  Fly   261 TSIIFLVALSEYDQILFESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEEKIMYSHL 325

Human   289 VDYFPEFDGPQRDAQAAREFILKMFVDLNPDSDKIIYSHFTCATDTENIRFVFAAVKDTILQLNL 353
            ||||||:|||||||..||||||:|||||||||:||||||||||||||||:.||.||||||:|..|
  Fly   326 VDYFPEYDGPQRDAITAREFILRMFVDLNPDSEKIIYSHFTCATDTENIKLVFCAVKDTIMQNAL 390

Human   354 KEYNL 358
            ||:||
  Fly   391 KEFNL 395

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GNA11	NP_002058.2	G-alpha	40..353	CDD:206639	254/355 (72%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	41..54		12/12 (100%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	178..186		6/7 (86%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	201..210		8/8 (100%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	270..277		6/6 (100%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	329..334		4/4 (100%)
Galphaq	NP_725192.2	G-alpha	34..390	CDD:206639	254/355 (72%)