back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GMPR and ras

DIOPT Version :9

Sequence 1:	NP_006868.3	Gene:	GMPR / 2766	HGNCID:	4376	Length:	345	Species:	Homo sapiens
Sequence 2:	NP_001356940.1	Gene:	ras / 43873	FlyBaseID:	FBgn0003204	Length:	590	Species:	Drosophila melanogaster

Alignment Length:	475	Identity:	113/475 - (23%)
Similarity:	169/475 - (35%)	Gaps:	157/475 - (33%)

- Green bases have known domain annotations that are detailed below.

Human     5 DADLK--------------LDFKDVLLRPKRSSLKSRAEVDLERTFTFRNSKQTYSGIPIIVANM 55
            ||:|:              |.:.|.|:.|......:. ||||....|    |......|::.:.|
  Fly    33 DAELQDGLSCKELFQNGEGLTYNDFLILPGYIDFTAE-EVDLSSPLT----KSLTLRAPLVSSPM 92

Human    56 DTVGTFEMAAVMSQHSMFTAIH------------------KHYSLDD------------------ 84
            |||...|||..|:.......||                  ||..:.|
  Fly    93 DTVTESEMAIAMALCGGIGIIHHNCTPEYQALEVHKVKKYKHGFMRDPSVMSPTNTVGDVLEARR 157

Human    85 ----------------WKL----------FATNHPECL-----QNVAVSSGSGQN---------- 108
                            .||          |..|.||.|     ....|::.:|.|
  Fly   158 KNGFTGYPVTENGKLGGKLLGMVTSRDIDFRENQPEVLLADIMTTELVTAPNGINLPTANAILEK 222

Human   109 ----------------------DLEKMTSILEAVPQ----------------------------V 123
                                  ||:|..|...|...                            |
  Fly   223 SKKGKLPIVNQAGELVAMIARTDLKKARSYPNASKDSNKQLLVGAAIGTRSEDKARLALLVANGV 287

Human   124 KFICLDVANGYSEHFVEFVKLVRAKFPEHTIMAGNVVTGEMVEELILSGADIIKVGVGPGSVCTT 188
            ..|.||.:.|.|.:.||.:|.::..:||..::.|||||....:.||.:|.|.::||:|.||:|.|
  Fly   288 DVIILDSSQGNSVYQVEMIKYIKETYPELQVIGGNVVTRAQAKNLIDAGVDGLRVGMGSGSICIT 352

Human   189 RTKTGVGYPQLSAVIECADSAHGLKGHIISDGGCTCPGDVAKAFGAGADFVMLGGMFSGHTECAG 253
            :.....|.||.:||.:.:..|......:|:|||....|.:.||...||..||:|.:.:|.:|..|
  Fly   353 QEVMACGCPQATAVYQVSTYARQFGVPVIADGGIQSIGHIVKAIALGASAVMMGSLLAGTSEAPG 417

Human   254 EVFERNGRKLKLFYGMSSDTAMNK-HAGGVA----------EYRASEGKTVEVPYKGDVENTILD 307
            |.|..:|.:||.:.||.|..||.: .|.|.|          :.:.::|.:..:..||.|...:..
  Fly   418 EYFFSDGVRLKKYRGMGSLEAMERGDAKGAAMSRYYHNEMDKMKVAQGVSGSIVDKGSVLRYLPY 482

Human   308 ILGGLRSTCTYVGAAKLKEL 327
            :..||:.:|..:||..:.:|
  Fly   483 LECGLQHSCQDIGANSINKL 502

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.