Protein Alignment GLRB and Rdl

DIOPT Version :9

• Sequence 1: NP_000815.1
• Gene: GLRB / 2743
• HGNCID: 4329
• Length: 497
• Species: Homo sapiens
• Sequence 2: NP_001261617.1
• Gene: Rdl / 39054
• FlyBaseID: FBgn0004244
• Length: 608
• Species: Drosophila melanogaster
• Alignment Length: 563
• Identity: 180/563 - (31%)
• Similarity: 261/563 - (46%)
• Gaps: 152/563 - (26%)

Human    57 SNILNRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRL---KL 118
            |.||:...||||.|:|||:.|.||:|.|.:::.|..|:.|..||:.::.:.||.|.||||   |.
  Fly    60 SAILDSFSVSYDKRVRPNYGGPPVEVGVTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRLAYRKR 124

Human   119 PSDFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSITLSC 183
            |    |.:.|:|.....|.:|.||.||.|||.:.||..|..|..:.:...|.:..|:||:||.||
  Fly   125 P----GVETLSVGSEFIKNIWVPDTFFVNEKQSYFHIATTSNEFIRVHHSGSITRSIRLTITASC 185

Human   184 PLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSG-DPVQL-EKIALPQFDIKKEDIEYGN---C 243
            |::|..||||.|.|.:::||||||..|:|:.|:.| ..|.: .::.||||.:      .|:   .
  Fly   186 PMNLQYFPMDRQLCHIEIESFGYTMRDIRYFWRDGLSSVGMSSEVELPQFRV------LGHRQRA 244

Human   244 TKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVPLGIFSVLS 308
            |:....||.|:.:.......|.:|:|::.:|.|:.|||::||:|||:|.:|:.|||.||:.:||:
  Fly   245 TEINLTTGNYSRLACEIQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRNATPARVALGVTTVLT 309

Human   309 LASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVMLNNPKRVEAEKARI------ 367
            :.:..::..|.|||:||||::||:|..|.:..||||:|||.|..|   .||::..|.|.
  Fly   310 MTTLMSSTNAALPKISYVKSIDVYLGTCFVMVFASLLEYATVGYM---AKRIQMRKQRFMAIQKI 371

Human   368 ----------AKAEQAD---------------------GKGGNV--------------------- 380
                      |..:||:                     |.||.|
  Fly   372 AEQKKQQLDGANQQQANPNPNANVGGPGGVGVGPGGPGGPGGGVNVGVGMGMGPEHGHGHGHHAH 436

Human   381 ------AKKNTVNGTGTPVHISTLQ--VGETRCKKVCTSKSDLRSNDFSIVGSLPRDFELSNYD- 436
                  |.|.||  :..|:..|.:|  ||...|               ||||.|.::.....:|
  Fly   437 SHGHPHAPKQTV--SNRPIGFSNIQQNVGTRGC---------------SIVGPLFQEVRFKVHDP 484

Human   437 ---CYGKPIE--VNNGLGKSQAK------------------NNKKPP----------PAKPVIPT 468
               ..|..:|  ||.|.|..|:.                  ....||          ||..:.|.
  Fly   485 KAHSKGGTLENTVNGGRGGPQSHGPGPGQGGGPPGGGGGGGGGGGPPEGGGDPEAAVPAHLLHPG 549

Human   469 AAKR--------------IDLYARALFPFCFLFFNVIYWSIYL 497
            ..|:              ||.|:|.:||.||:.||::||.|||
  Fly   550 KVKKVKDINKLLGITPSDIDKYSRIVFPVCFVCFNLMYWIIYL 592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GLRB	NP_000815.1	LIC	43..496	CDD:273305	177/560 (32%)
		LGIC_ECD_GlyR_beta	79..265	CDD:349811	70/193 (36%)
		Strychnine-binding. /evidence=ECO:0000250|UniProtKB:O93430	247..253		2/5 (40%)
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	69/192 (36%)
		Neur_chan_memb	274..588	CDD:397193	90/333 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X271
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.810