DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HTRA2 and NMA111

DIOPT Version :10

Sequence 1:NP_037379.1 Gene:HTRA2 / 27429 HGNCID:14348 Length:458 Species:Homo sapiens
Sequence 2:NP_014276.1 Gene:NMA111 / 855600 SGDID:S000005067 Length:997 Species:Saccharomyces cerevisiae


Alignment Length:328 Identity:94/328 - (28%)
Similarity:144/328 - (43%) Gaps:37/328 - (11%)


- Green bases have known domain annotations that are detailed below.


Human   148 NFIADVVEKTAPAVVYIEILDRHPFLGREVPISNGSGFVVAAD-GLIVTNAHVVADRRRVRVRLL 211
            |.|::||:    :||.|......||......:|..:||||.|. |:|:||.|||.....|...:.
Yeast    74 NTISNVVK----SVVSIHFSQVAPFDCDSALVSEATGFVVDAKLGIILTNRHVVGPGPFVGYVVF 134

Human   212 SGDTYE---AVVTAVDPVADIATLRIQTK----EPLPTLPLGRSADVRQGEFVVAMGSPFALQNT 269
              |.:|   .:....|||.|...|:...|    ..:..|.|..|. .:.|..:..:|:....:.:
Yeast   135 --DNHEECDVIPIYRDPVHDFGFLKFDPKNIKYSKIKALTLKPSL-AKVGSEIRVVGNDAGEKLS 196

Human   270 ITSGIVSSAQRPARDLG---LPQTNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKVT-AGIS 330
            |.:|.:|...|.|.:.|   ....|.||||..|:...|:||.|:||:||..:.:.....| |...
Yeast   197 ILAGFISRIDRNAPEYGELTYNDFNTEYIQAAASASGGSSGSPVVNIDGYAVALQAGGSTEASTD 261

Human   331 FAIPSDR-LREFLHRGEKKNSSSGISGSQ---RRYIGVMMLTLSPSILAELQLREPSFPDVQHGV 391
            |.:|.|| ||..:.....|..:.|....|   :.|.....|.|:....:|.:.:   ||: ..|:
Yeast   262 FFLPLDRILRALICIQTNKPITRGTIQVQWLLKPYDECRRLGLTSERESEARAK---FPE-NIGL 322

Human   392 LIHKVILGSPAHRAGLRPGDVILAI-GE-----QMVQNAEDVYEAVRTQSQLAVQIRRGRE-TLT 449
            |:.:.:|........::.||.:::| ||     ..|...:|  |.|..:.||.:| |.|.| |:|
Yeast   323 LVAETVLREGPGYDKIKEGDTLISINGETISSFMQVDKIQD--ENVGKEIQLVIQ-RGGVECTVT 384

Human   450 LYV 452
            ..|
Yeast   385 CTV 387

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HTRA2NP_037379.1 IAP-binding motif 134..137
Serine protease 166..342 57/188 (30%)
DegQ 182..455 CDD:440035 84/294 (29%)
NMA111NP_014276.1 DUF5923 <42..91 CDD:466049 7/20 (35%)
DegQ 102..390 CDD:440035 85/296 (29%)
cpPDZ1_ScNma111-like 299..387 CDD:467625 25/94 (27%)
PDZ_1 392..469 CDD:372324
DegQ 572..865 CDD:440035
cpPDZ3_ScNma111-like 772..862 CDD:467627
PDZ2-4_Nma111p-like 871..950 CDD:467617
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.