Protein Alignment HTRA2 and Htra2

DIOPT Version :10

• Sequence 1: NP_037379.1
• Gene: HTRA2 / 27429
• HGNCID: 14348
• Length: 458
• Species: Homo sapiens
• Sequence 2: NP_062726.3
• Gene: Htra2 / 64704
• MGIID: 1928676
• Length: 458
• Species: Mus musculus
• Alignment Length: 458
• Identity: 389/458 - (84%)
• Similarity: 409/458 - (89%)
• Gaps: 0/458 - (0%)

Human     1 MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWARLSVGV 65
            |||.:|||||.||||||||||||.|.:.|.|.|||||||||||.|.:..:|||||||.|::..|.
Mouse     1 MAALKAGRGANWSLRAWRALGGIFWRKPPLLAPDLRALLTSGTPDSQIWMTYGTPSLPAQVPEGF 65

Human    66 TEPRACLTSGTPGPRAQLTAVTPDTRTREASENSGTRSRAWLAVALGAGGAVLLLLWGGGRGPPA 130
            ...||.|||.||...|:|...|..:..:||..:.|:|.|.|||||:||||||:|||||.|||...
Mouse    66 LASRADLTSRTPDLWARLNVGTSGSSDQEARRSPGSRRREWLAVAVGAGGAVVLLLWGWGRGLST 130

Human   131 VLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPISNGSGFVVAADGLIVT 195
            ||||||:|||.|||||||||||||||||||||||||||||||.|||||||||||||||:||||||
Mouse   131 VLAAVPAPPPTSPRSQYNFIADVVEKTAPAVVYIEILDRHPFSGREVPISNGSGFVVASDGLIVT 195

Human   196 NAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKEPLPTLPLGRSADVRQGEFVVAM 260
            |||||||||||||||.|||||||:|||||||||||||||||||||||||||||||||||||||||
Mouse   196 NAHVVADRRRVRVRLPSGDTYEAMVTAVDPVADIATLRIQTKEPLPTLPLGRSADVRQGEFVVAM 260

Human   261 GSPFALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKV 325
            |||||||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||
Mouse   261 GSPFALQNTITSGIVSSAQRPARDLGLPQNNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKV 325

Human   326 TAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRRYIGVMMLTLSPSILAELQLREPSFPDVQHG 390
            |||||||||||||||||||||||||..|.|||||||||||||||:||||.|||||||||||||||
Mouse   326 TAGISFAIPSDRLREFLHRGEKKNSWFGTSGSQRRYIGVMMLTLTPSILIELQLREPSFPDVQHG 390

Human   391 VLIHKVILGSPAHRAGLRPGDVILAIGEQMVQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPE 455
            ||||||||||||||||||||||||||||::.||||||||||||||||||:||||.||||||||||
Mouse   391 VLIHKVILGSPAHRAGLRPGDVILAIGEKLAQNAEDVYEAVRTQSQLAVRIRRGSETLTLYVTPE 455

Human   456 VTE 458
            |||
Mouse   456 VTE 458

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HTRA2	NP_037379.1	IAP-binding motif	134..137		2/2 (100%)
		Serine protease	166..342		170/175 (97%)
		DegQ	182..455	CDD:440035	258/272 (95%)
Htra2	NP_062726.3	IAP-binding motif. /evidence=ECO:0000250	134..137		2/2 (100%)
		Serine protease	166..342		170/175 (97%)
		DegQ	182..455	CDD:440035	258/272 (95%)