DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HTRA2 and HtrA2

DIOPT Version :9

Sequence 1:	NP_037379.1	Gene:	HTRA2 / 27429	HGNCID:	14348	Length:	458	Species:	Homo sapiens
Sequence 2:	NP_001262565.1	Gene:	HtrA2 / 41756	FlyBaseID:	FBgn0038233	Length:	422	Species:	Drosophila melanogaster

Alignment Length:	386	Identity:	175/386 - (45%)
Similarity:	243/386 - (62%)	Gaps:	44/386 - (11%)

- Green bases have known domain annotations that are detailed below.

Human    97 ENSGTRSRAW-------LAVALGAGGAVLLLLWGGGRGPPAVLAAVPSPPPASP----------R 144
            :|...:.:.|       :..:|||                .|.||:......:|          |
  Fly    52 QNGEQKEKGWRRLVRFFVPFSLGA----------------VVSAAIIQREDLTPTIAASKMTGRR 100

Human   145 SQYNFIADVVEKTAPAVVYIEILD-RH--PFLGREVPISNGSGFVVAADGLIVTNAHVVADR--R 204
            ..:|||||||...|.:||||||.| ||  .|.|:.:..||||||::..:|||:||||||.::  .
  Fly   101 RDFNFIADVVAGCADSVVYIEIKDTRHFDYFSGQPITASNGSGFIIEQNGLILTNAHVVINKPHT 165

Human   205 RVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSPFALQNT 269
            .|:|||..|.|:.|.:..||..:|:||||||... |..:.||:|:.:|.||:|||:|||.||.||
  Fly   166 MVQVRLSDGRTFPATIEDVDQTSDLATLRIQVNN-LSVMRLGKSSTLRSGEWVVALGSPLALSNT 229

Human   270 ITSGIVSSAQRPARDLGLPQTNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIP 334
            :|:|::||.||.:::|||...::.|:||||||.||||||||||||||.||||:||||||||||||
  Fly   230 VTAGVISSTQRASQELGLRNRDINYLQTDAAITFGNSGGPLVNLDGEAIGVNSMKVTAGISFAIP 294

Human   335 SDRLREFLHRG---EKKNSSSGISGSQRRYIGVMMLTLSPSILAELQLREPSFP-DVQHGVLIHK 395
            .|.::.||.|.   .||.|:.......:||:|:.||||:|.||.||:.|..:.| ::.||||:.|
  Fly   295 IDYVKVFLERAAEKRKKGSAYKTGYPVKRYMGITMLTLTPDILFELKSRSQNMPSNLTHGVLVWK 359

Human   396 VILGSPAHRAGLRPGDVILAIGEQMVQNAEDVYEAVRTQSQ-LAVQIRRGRETLTLYVTPE 455
            ||:|||||..||:|||::..|.::.::|:.|||:|:...|: |.:.|.||.:.:.:.:|||
  Fly   360 VIVGSPAHSGGLQPGDIVTHINKKEIKNSSDVYDALADNSKTLDIVILRGVKQMHVTITPE 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HTRA2	NP_037379.1	IAP-binding motif	134..137		1/2 (50%)
		DegQ	150..>453	CDD:333159	160/312 (51%)
		Serine protease	166..342		101/180 (56%)
HtrA2	NP_001262565.1	DegQ	67..422	CDD:223343	173/371 (47%)
		Trypsin_2	141..280	CDD:290102	77/139 (55%)
		PDZ_serine_protease	323..417	CDD:238487	42/93 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146070
Domainoid	1	1.000	166	1.000	Domainoid score	I3884
eggNOG	1	0.900	-	-		E1_COG0265
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H113300
Inparanoid	1	1.050	301	1.000	Inparanoid score	I2690
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D238833at33208
OrthoFinder	1	1.000	-	-		FOG0000153
OrthoInspector	1	1.000	-	-		otm42040
orthoMCL	1	0.900	-	-		OOG6_100391
Panther	1	1.100	-	-	LDO	PTHR22939
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2207
SonicParanoid	1	1.000	-	-		X265
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790