Protein Alignment HTRA2 and htr11

DIOPT Version :10

• Sequence 1: NP_037379.1
• Gene: HTRA2 / 27429
• HGNCID: 14348
• Length: 458
• Species: Homo sapiens
• Sequence 2: NP_595209.1
• Gene: htr11 / 2539936
• PomBaseID: SPBC1685.05
• Length: 997
• Species: Schizosaccharomyces pombe
• Alignment Length: 265
• Identity: 62/265 - (23%)
• Similarity: 110/265 - (41%)
• Gaps: 55/265 - (20%)

Human   183 SGFVVAAD-GLIVTNAHVVADRR-RVRVRLLSGDTYEAVVTAVDPVADI-------ATLRIQTKE 238
            :||||... |||::|.|||:... ..|...::.:..:......|||.|.       :::|.....
pombe   100 TGFVVNKTLGLILSNRHVVSPGPISARASFINYEEIDIYPIYRDPVHDFGFFRYDPSSIRFHDVT 164

Human   239 PLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLP---QTNVEYIQTDAA 300
            .:...|  .||.|  |..:..:|:....:.:|.|..::...|||.:.|:.   ..|..|.|..:.
pombe   165 EISLSP--ESAKV--GIDIRIIGNDAGEKLSILSSTLARLDRPAPNYGIDNYNDFNTFYYQAASG 225

Human   301 IDFGNSGGPLVNLDGEVIGVNT-MKVTAGISFAIPSDR-------------------LREFLHRG 345
            ...|:||.|::::.|..:.:|: ...::..||.:|.||                   |.||||..
pombe   226 TSGGSSGSPVLDISGAAVALNSGGSNSSASSFYLPLDRVVRALRCIENNTPITRGTLLTEFLHWS 290

Human   346 EKKNSSSGISGSQRRYIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGSPAHRAGLRPG 410
            ..:.|..|:. .:..|              :.:.|.||...:   :::.:|:..|...:| |.||
pombe   291 YDELSRIGLP-REFEY--------------DCRTRVPSSTGL---LVVSRVLRNSEVSKA-LEPG 336

Human   411 DVILA 415
            |:::|
pombe   337 DILIA 341

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HTRA2	NP_037379.1	IAP-binding motif	134..137
		Serine protease	166..342		45/190 (24%)
		DegQ	182..455	CDD:440035	62/265 (23%)
htr11	NP_595209.1	Trypsin_2	99..245	CDD:433149	37/148 (25%)
		cpPDZ1_ScNma111-like	294..387	CDD:467625	14/67 (21%)
		PDZ2-4_Nma111p-like	398..475	CDD:467617
		degP_htrA_DO	<807..963	CDD:273938
		cpPDZ_Deg_HtrA-like	<808..856	CDD:483954