Protein Alignment GLRA2 and SecCl

DIOPT Version :9

• Sequence 1: NP_001112357.1
• Gene: GLRA2 / 2742
• HGNCID: 4327
• Length: 452
• Species: Homo sapiens
• Sequence 2: NP_001261986.1
• Gene: SecCl / 39949
• FlyBaseID: FBgn0036727
• Length: 509
• Species: Drosophila melanogaster
• Alignment Length: 458
• Identity: 127/458 - (27%)
• Similarity: 208/458 - (45%)
• Gaps: 88/458 - (19%)

Human    58 YDARIRP-----NFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEY-PDDS 116
            ||...||     :.|..|:.|...|::....::....:.::::..|:.::.|.||||..: ..|:
  Fly    57 YDRLERPFEYDSDGKRLPIVVKTRIYVYFLQNLNSDLLQFKMHALLQLRFQDKRLAYKAFNRSDN 121

Human   117 LDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNK--LLRISKNGKVLYSIRLTLTLSCPMDLKNF 179
            :.....:.:.:|.|.:|||||:.::.  :.||.|  |..:|..|.|:.|.|:..:|.|.|:.:.|
  Fly   122 ILGQKHLSERLWLPHIFFANERESSI--LGTDEKDVLTSLSPEGNVIISTRMQASLYCWMNFQKF 184

Human   180 PMDVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKELGYCTKHYNT------ 238
            |.|.|.|:..|||:.|..:|||.||....|:.....:.|.::.:.:        ..:||
  Fly   185 PFDQQFCSTVLESWMYNTSDLILEWEPHTPISFDPEMRLTEYNMAQ--------FWHNTTIVQSD 241

Human   239 ----------GKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITT 293
                      |.::.:....:|:|::|:||:..|:||::||.:||||||:..||:|.|:.||.:|
  Fly   242 GDNLRHGAFAGNYSSLSFTVNLKREIGFYLLDYYLPSMMIVAISWVSFWLQADASPPRIMLGTST 306

Human   294 VLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLRLRR----- 353
            :|:..|.||....:||||||:|..::|...|..|:|.:|:|:|.||.:.|: ||.:.|::
  Fly   307 MLSFITLSSSQSKNLPKVSYIKVSEVWFLGCTFFIFGSLVEFAFVNTIWRR-KENIELKKVNSKY 370

Human   354 --------RQKRQNKEEDVTRESRF-------------------------NFSGYGMGH------ 379
                    |..|:.....::.|||.                         .|:.|...|
  Fly   371 IIKSTLTPRPARRQIGGSLSNESRARSCSSLDNIVSSTESVRNGNGTVNQGFNNYLTVHPNLPII 435

Human   380 ---CLQVKDGTAVKATPANP-LPQPPKDGDAIKKKFV-----DRAKRIDTISRAAFPLAFLIFNI 435
               |.:....:...|...|. :....||.......|.     :.|..||..||..||..||.||.
  Fly   436 RTECAEADTVSICSARTNNDHIVDVDKDKKDTPPTFTTMTPQEIAMWIDRRSRFLFPAMFLAFNA 500

Human   436 FYW 438
            .||
  Fly   501 LYW 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GLRA2	NP_001112357.1	LIC	46..441	CDD:273305	127/458 (28%)
		Strychnine-binding. /evidence=ECO:0000250|UniProtKB:O93430	236..241		3/20 (15%)
SecCl	NP_001261986.1	LIC	43..505	CDD:273305	127/458 (28%)
		Neur_chan_LBD	44..267	CDD:280998	55/219 (25%)
		Neur_chan_memb	275..503	CDD:280999	67/228 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910