Protein Alignment GLRA2 and Rdl

DIOPT Version :9

• Sequence 1: NP_001112357.1
• Gene: GLRA2 / 2742
• HGNCID: 4327
• Length: 452
• Species: Homo sapiens
• Sequence 2: NP_001261617.1
• Gene: Rdl / 39054
• FlyBaseID: FBgn0004244
• Length: 608
• Species: Drosophila melanogaster
• Alignment Length: 528
• Identity: 174/528 - (32%)
• Similarity: 257/528 - (48%)
• Gaps: 150/528 - (28%)

Human    58 YDARIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEYPD-DSLDLDP 121
            ||.|:|||:.||||.|...:::.|..|::|..||:.::.:.||.|.|.||||.:.|. ::|.:..
  Fly    70 YDKRVRPNYGGPPVEVGVTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRLAYRKRPGVETLSVGS 134

Human   122 SMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTC 186
            ..:.:||.||.||.|||.:.||..||.|:.:|:..:|.:..|||||:|.||||:|:.||||.|.|
  Fly   135 EFIKNIWVPDTFFVNEKQSYFHIATTSNEFIRVHHSGSITRSIRLTITASCPMNLQYFPMDRQLC 199

Human   187 TMQLESFGYTMNDLIFEWLSDG--PVQVAEGLTLPQFILKEEKELGYCTK----HYNTGKFTCIE 245
            .:::|||||||.|:.:.| .||  .|.::..:.||||     :.||:..:    :..||.::.:.
  Fly   200 HIEIESFGYTMRDIRYFW-RDGLSSVGMSSEVELPQF-----RVLGHRQRATEINLTTGNYSRLA 258

Human   246 VKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPK 310
            .:....|.|||||||:||||.||||:||||||:|.:|.|||||||:||||||||..|.:.|:|||
  Fly   259 CEIQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRNATPARVALGVTTVLTMTTLMSSTNAALPK 323

Human   311 VSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSR----QHKEFLRLRRRQKRQNKEEDVTRESRFN 371
            :||||:||:::..|.:.|||:|||||.|.::::    :.:.|:.:::..:::.::.|...:.:.|
  Fly   324 ISYVKSIDVYLGTCFVMVFASLLEYATVGYMAKRIQMRKQRFMAIQKIAEQKKQQLDGANQQQAN 388

Human   372 FS-----------------------------GYGMG---------HCLQVKDGTAVKATPAN--- 395
            .:                             |.|||         |........|.|.|.:|
  Fly   389 PNPNANVGGPGGVGVGPGGPGGPGGGVNVGVGMGMGPEHGHGHGHHAHSHGHPHAPKQTVSNRPI 453

Human   396 ------------------PL------------------------------PQ------------- 399
                              ||                              ||
  Fly   454 GFSNIQQNVGTRGCSIVGPLFQEVRFKVHDPKAHSKGGTLENTVNGGRGGPQSHGPGPGQGGGPP 518

Human   400 -----------PPKDG--------------DAIKK-KFVDR-----AKRIDTISRAAFPLAFLIF 433
                       ||:.|              ..:|| |.:::     ...||..||..||:.|:.|
  Fly   519 GGGGGGGGGGGPPEGGGDPEAAVPAHLLHPGKVKKVKDINKLLGITPSDIDKYSRIVFPVCFVCF 583

Human   434 NIFYWITY 441
            |:.|||.|
  Fly   584 NLMYWIIY 591

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GLRA2	NP_001112357.1	LIC	46..441	CDD:273305	173/526 (33%)
		Strychnine-binding. /evidence=ECO:0000250|UniProtKB:O93430	236..241		2/4 (50%)
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	70/188 (37%)
		Neur_chan_memb	274..588	CDD:397193	83/313 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X271
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810