Protein Alignment GLRA2 and nAChRalpha7

DIOPT Version :10

• Sequence 1: NP_002054.1
• Gene: GLRA2 / 2742
• HGNCID: 4327
• Length: 452
• Species: Homo sapiens
• Sequence 2: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Alignment Length: 481
• Identity: 106/481 - (22%)
• Similarity: 179/481 - (37%)
• Gaps: 126/481 - (26%)

Human    58 YDARIRPNF-KGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAY--SEYPD-DSLD 118
            |::..||.. :..|:.::..:.:.....|.|.......||:|:.:|||..|.:  ||:.. ..|.
  Fly    72 YNSLERPVVNESDPLQLSFGLTLMQIIDVDEKNQLLITNIWLKLEWNDMNLRWNSSEFGGVRDLR 136

Human   119 LDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDV 183
            :.|..|   ||||:...|.....|......|.::|  .||..||........:|.:|:..||.|.
  Fly   137 IPPHRL---WKPDVLMYNSADEGFDGTYATNVVVR--NNGSCLYVPPGIFKSTCKIDITWFPFDD 196

Human   184 QTCTMQLESFGYTMNDLIFEWLSDG-----PVQVAEGLTLPQFILKEEKE-LGYCTK----HYNT 238
            |.|.|:   ||        .|..||     .:|...|..:..||...|.: ||...|    :||.
  Fly   197 QRCEMK---FG--------SWTYDGFQLDLQLQDEAGGDISSFITNGEWDLLGVPGKRNEIYYNC 250

Human   239 GKFTCIEVKFH--LERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQS 301
            .....|::.|.  :.|:..||...:.:|.:||..::.:.|.:..|:. .:::||:|.:|::|...
  Fly   251 CPEPYIDITFAILIRRKTLYYFFNLIVPCVLIASMALLGFTLPPDSG-EKLSLGVTILLSLTVFL 314

Human   302 SGSRASLPKVSYVKAIDIWMAVCLLFVFAA-------LLEYAAVNFVSRQHKEFLRL-------- 351
            :....::|..|....:......|::|:.|:       :|.|...|..:.:..|::|:
  Fly   315 NMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNPDTHEMSEWIRVIFLYWLPC 379

Human   352 ---------------------------RRRQKRQN---KEE----------DVTRESRFNFSGYG 376
                                       .::|:.||   ||.          |:..:.|.|.
  Fly   380 ILRMQRPGQVGYECPPPPSSSSSSASGEKKQQIQNVELKERSSKSLLANVLDIDDDFRCNH---- 440

Human   377 MGHCL----------------QVKDGTAVKATPANPLPQPPKDG---DAIKKKFVDRAKRIDTIS 422
              .|.                |..||:.....||.|:    .||   :||....:        .|
  Fly   441 --RCASATLPHQPTYYRTMYRQGDDGSVGPVGPAGPV----VDGRLHEAISHTCL--------TS 491

Human   423 RAAFPLAFLIFNIFYWITYKIIRHED 448
            .|.:.|| ||.....|||.::.:.::
  Fly   492 SAEYELA-LILKELRWITEQLKKEDE 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GLRA2	NP_002054.1	LIC	46..441	CDD:273305	105/472 (22%)
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:455710	106/481 (22%)