Protein Alignment GLRA2 and Lcch3

DIOPT Version :10

• Sequence 1: NP_002054.1
• Gene: GLRA2 / 2742
• HGNCID: 4327
• Length: 452
• Species: Homo sapiens
• Sequence 2: NP_996469.1
• Gene: Lcch3 / 32554
• FlyBaseID: FBgn0010240
• Length: 496
• Species: Drosophila melanogaster
• Alignment Length: 505
• Identity: 189/505 - (37%)
• Similarity: 273/505 - (54%)
• Gaps: 87/505 - (17%)

Human     6 VNILTALFAFFLETNHFRTAFCKDHDSRSGKQPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPP 70
            |.:...|| |||.....:...|...|..:|:..:.|.:.|:.|       .|||.|:||||.|.|
  Fly     7 VGVSCGLF-FFLLGAQLQLIRCIRKDVLAGRLENVTQTISNIL-------QGYDIRLRPNFGGEP 63

Human    71 VNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYS---EYPDDS--------LDLDPSML 124
            ::|..::.|.||.:::|..|||.:.::|.|.|.|.|||::   :|.||.        |.|.....
  Fly    64 LHVGMDLTIASFDAISEVNMDYTITMYLNQYWRDERLAFNIFGQYFDDENDDGISDVLTLSGDFA 128

Human   125 DSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQ 189
            :.||.||.||||:|.:..||||..|||:|:..:|.|.|.:|.|.||:|.|||..:|:|.|.||::
  Fly   129 EKIWVPDTFFANDKNSFLHDVTERNKLVRLGGDGAVTYGMRFTTTLACMMDLHYYPLDSQNCTVE 193

Human   190 LESFGYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKELGYCT----KHYNTGKFTCIEVKFHL 250
            :||:|||::|::..| ...||:..|...||||.:     :||.|    :...||.:..:.:.|.|
  Fly   194 IESYGYTVSDVVMYW-KPTPVRGVEDAELPQFTI-----IGYETNDRKERLATGVYQRLSLSFKL 252

Human   251 ERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVK 315
            :|.:||::.|.|:||:|||:|||||||||.:|..|||||||||||||||.|:|.|:|||::||||
  Fly   253 QRNIGYFVFQTYLPSILIVMLSWVSFWINHEATSARVALGITTVLTMTTISTGVRSSLPRISYVK 317

Human   316 AIDIWMAVCLLFVFAALLEYAAVNFV---SRQHKEFLRLR----------RRQKRQNKEEDV--- 364
            ||||::.:|.:|||||||||||||:.   .|..|:..:::          .|.:..:..||:
  Fly   318 AIDIYLVMCFVFVFAALLEYAAVNYTYWGKRAKKKIKKVKECCPGKIGKSERSETCSTTEDIIEL 382

Human   365 ----------TRESRFNFS----------------------GYGMGHC---LQVKDGTAVKATPA 394
                      .|...:|.:                      .||.||.   .:.:.|.:.:....
  Fly   383 QDVRMSPIPSLRRGTYNATLDSIGTETMNLGKFPPSFRITRNYGTGHSQLRRRAQRGISTRPRML 447

Human   395 NPLPQPPKDGDAIKKKFVDRAKR---IDTISRAAFPLAFLIFNIFYWITY 441
            :.|    |.|.:..|..:.:.|.   ||..||..||::||.||:.||:.|
  Fly   448 HAL----KRGASAIKATIPKIKDVNIIDKYSRMIFPISFLAFNLGYWLFY 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GLRA2	NP_002054.1	LIC	46..441	CDD:273305	177/463 (38%)
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	185/494 (37%)