Protein Alignment GLRA2 and CG8916

DIOPT Version :9

• Sequence 1: NP_001112357.1
• Gene: GLRA2 / 2742
• HGNCID: 4327
• Length: 452
• Species: Homo sapiens
• Sequence 2: NP_573090.3
• Gene: CG8916 / 32553
• FlyBaseID: FBgn0030707
• Length: 612
• Species: Drosophila melanogaster
• Alignment Length: 508
• Identity: 160/508 - (31%)
• Similarity: 243/508 - (47%)
• Gaps: 117/508 - (23%)

Human    45 SDFLDKLMGRTSGYD-ARIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLA 108
            |..|:.|:.|   |: :::..:.:|.|..|..||.|.|.|.|:|..|||.::.:.||.|.|.||:
  Fly   109 SMILENLLKR---YEQSQLPTHGQGVPTVVQTNILIRSMGPVSELDMDYSMDCYFRQYWRDKRLS 170

Human   109 YSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCP 173
            : :.|..||.|...|||.||:||.:|.|.|.:..|.:|..|||||:.:||.:|||:|||:..:||
  Fly   171 F-KGPIKSLSLSIKMLDKIWRPDTYFYNGKHSQIHMITVPNKLLRLDQNGGILYSMRLTIKATCP 234

Human   174 MDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLS-DGPVQVAEGLTLPQFILKEEKELGYCTKHYN 237
            |:|:|||||.|:|.:.:.|:||....||:||.: |..|....|:||.||.|.......:.|.. .
  Fly   235 MELQNFPMDRQSCPLVIGSYGYINQQLIYEWKNQDDAVSFVPGMTLNQFDLISMMHRNFTTVR-R 298

Human   238 TGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSS 302
            .|.|:.:.|.|:|:|..||:|||:|:|.:|||:||||||||:.:|...||:|.:|:|||::|.|.
  Fly   299 EGDFSVLHVAFNLKRHTGYFLIQVYVPCILIVVLSWVSFWIHREATSDRVSLCVTSVLTLSTISL 363

Human   303 GSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQNK------- 360
            .||..||||.|..|:|.::.:..|:..|.|||:|.|::       |.:|...:..|.:
  Fly   364 DSRTDLPKVKYATALDWFLLMSFLYCIATLLEFAGVHY-------FTKLGSGESPQLEDQWEDIC 421

Human   361 ------------------------EEDVTRESRFNFSGYGMGHCLQVKDGTAV------------ 389
                                    :||.:..|..:.:..|....::.|.|..|
  Fly   422 IANSLSDHAGEVDGDGEADADPFADEDSSNGSENDDNEAGASESVESKSGVCVCNKNDALGLEYE 486

Human   390 ----------------------KATPANPLP---------QPP------------KDGDAIKKK- 410
                                  ...|:..||         :||            |..::.:|:
  Fly   487 VSLQNSLAGAGFLKRNAIFCPTYNDPSYILPNTMERTTQTEPPAVSRLHQMWMCLKSDNSFRKQR 551

Human   411 ----------------FVDRAKRIDTISRAAFPLAFLIFNIFYWITYKIIRHE 447
                            :|:....||.::|.|||::|...|:.||..|.:.:.|
  Fly   552 ERNAAAQKSEQGGANCYVNSVSLIDRVARIAFPMSFAFLNLLYWWAYGMYKKE 604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GLRA2	NP_001112357.1	LIC	46..441	CDD:273305	157/499 (31%)
		Strychnine-binding. /evidence=ECO:0000250|UniProtKB:O93430	236..241		1/4 (25%)
CG8916	NP_573090.3	LIC	92..598	CDD:273305	158/500 (32%)
		Neur_chan_LBD	111..315	CDD:280998	85/208 (41%)
		Neur_chan_memb	322..>403	CDD:280999	39/87 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810