DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sergef and CG9135

DIOPT Version :9

Sequence 1:	XP_006541006.1	Gene:	Sergef / 27414	MGIID:	1351630	Length:	465	Species:	Mus musculus
Sequence 2:	NP_001285655.1	Gene:	CG9135 / 33850	FlyBaseID:	FBgn0031769	Length:	487	Species:	Drosophila melanogaster

Alignment Length:	387	Identity:	95/387 - (24%)
Similarity:	153/387 - (39%)	Gaps:	119/387 - (30%)

- Green bases have known domain annotations that are detailed below.

Mouse    22 GANSYGQLGLGHKEDVFL---PQQLSDFCQAGCIKSVTGGGGHSAVVTDGGDLFVCGLNKDGQLG 83
            |.|..|||||  .:|:.|   |..:....|...:::.. |..|:..:||.|.::.||.||.||.|
  Fly   141 GRNPSGQLGL--SQDIKLAEKPTIIPALEQLNIVQAAV-GRHHTLFLTDTGTVYACGENKSGQCG 202

Mouse    84 LGHTEEVLRFTICKP----LRGCPIRQVACGWDFTIMLTEKGQVLSCGSNAFGQLGVPH------ 138
            :|:|..    .|..|    .||.||.::.||.:|:::|..||.:.:.|...:||||  |
  Fly   203 VGNTHA----NIYSPTPINYRGPPIIRIGCGAEFSVILDIKGSLHTFGLPEYGQLG--HNTDAKY 261

Mouse   139 -------------GPRKCVVPQAIECLRE---------KVVCVAAGLRHALATTATGSVFQWGTG 181
                         .|:|.|:  .||..:|         ::|..|.|..|.:|..:...|:.||.|
  Fly   262 FVNANKLSFHFETSPKKVVL--YIEKSKEGHVTPVDGVQIVDFACGNNHTVAIDSKKRVYSWGFG 324

Mouse   182 LASSGRRLCPGQNLPLFLTAKEPS-----------RVTGLENSTAVCAVAGSDHSASLTDTGELY 235
              ..||           |...||.           ...|....:..|   ||..|..:.:.|.|:
  Fly   325 --GFGR-----------LGHAEPKDEMVPRLMKFFDTQGRGGRSVFC---GSTFSLIVNELGLLF 373

Mouse   236 VWGRNKHGQLASRAVFLPLPQRIEAHYFQDEKVTAVWSGW----------THLVAKTETGKVFTW 290
            ::|:||.   ...|...|.|       .||      .|||          :.:::..:|  :..|
  Fly   374 LFGQNKK---TGEANMYPKP-------VQD------LSGWNITDIGCANTSIMISADDT--LIAW 420

Mouse   291 GRA-DYGQLGRRLEPPEAQKPVEQDSSLAFQGPQ-NSVPSPLHCLTGATEISCGSEHNLAVI 350
            |.: .:|:||    ..|.||    .|::..:.|: :::..|        :::.|..|.:.::
  Fly   421 GASPTFGELG----IGEFQK----SSTVPKEVPKLDNIKIP--------QVTMGYSHTVLLV 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sergef	XP_006541006.1	ATS1	22..370	CDD:227511	95/387 (25%)
Sergef	XP_006541006.1	RCC1	356..402	CDD:366085
CG9135	NP_001285655.1	RCC1	139..184	CDD:278826	13/45 (29%)
		RCC1_2	171..200	CDD:290274	9/29 (31%)
		RCC1	188..236	CDD:278826	19/51 (37%)
		RCC1	239..312	CDD:278826	18/76 (24%)
		RCC1	317..366	CDD:278826	14/64 (22%)
		RCC1	414..465	CDD:278826	14/68 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5530
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.850