DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GLRA1 and GluClalpha

DIOPT Version :9

Sequence 1:	NP_001139512.1	Gene:	GLRA1 / 2741	HGNCID:	4326	Length:	457	Species:	Homo sapiens
Sequence 2:	NP_001287408.1	Gene:	GluClalpha / 42350	FlyBaseID:	FBgn0024963	Length:	463	Species:	Drosophila melanogaster

Alignment Length:	468	Identity:	196/468 - (41%)
Similarity:	266/468 - (56%)	Gaps:	35/468 - (7%)

- Green bases have known domain annotations that are detailed below.

Human    10 YLWETIVFFSLAASKEAEAA----RSAPKPMSPSDFLDKLMGRTSGYDARIRPN----FKGPPVN 66
            |.|..:.|.||.::..|..|    |...|.:     ||:::| ...|||||||:    ..||.|
  Fly     6 YFWAILYFASLCSASLANNAKINFREKEKKV-----LDQILG-AGKYDARIRPSGINGTDGPAV- 63

Human    67 VSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDSIWKPDLFFANE 131
            |..|||:.|...|.:.||:|.|.:..|:||.|.||.:::.......|..:..:.:|.|||||:||
  Fly    64 VRVNIFVRSISKIDDVTMEYSVQLTFREQWTDERLKFDDIQGRLKYLTLTEANRVWMPDLFFSNE 128

Human   132 KGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIF 196
            |..|||.|...|..:||..||:|||||||:|||||||:||.:|:|.|.|.:::.|:|:|.|||:|
  Fly   129 KEGHFHNIIMPNVYIRIFPNGSVLYSIRISLTLACPMNLKLYPLDRQICSLRMASYGWTTNDLVF 193

Human   197 EWQEQGAVQVADGLTLPQFILKEEKDLR-YCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSL 260
            .|:|...|||...|.||:|.|  ||.|. ||....|||:::|::.....:|:..|||||:|||..
  Fly   194 LWKEGDPVQVVKNLHLPRFTL--EKFLTDYCNSKTNTGEYSCLKVDLLFKREFSYYLIQIYIPCC 256

Human   261 LIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSA 325
            ::||:||:|||::..|.||||.||:||:|||.||:||..||||.|||.||||:|..|||.|||.|
  Fly   257 MLVIVSWVSFWLDQGAVPARVSLGVTTLLTMATQTSGINASLPPVSYTKAIDVWTGVCLTFVFGA 321

Human   326 LLEYAAVNFVSR-------QHKELLRFRRKRRHHKSPMLNLFQE--DEAGEGRFNFS---AYGMG 378
            |||:|.||:.||       .|||  ..::|||..:...|:...:  |......|..:   |.|.|
  Fly   322 LLEFALVNYASRSGSNKANMHKE--NMKKKRRDLEQASLDAASDLLDTDSNATFAMASQFARGGG 384

Human   379 ---PACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQRAKKIDKISRIGFPMAFLIFNM 440
               |......|.::::...........|......:.....|..|:|:||.||||.||:.|.:||:
  Fly   385 QQKPLVRHPGDPLALEKRLQCEVHMQAPKRPNCCKTWLSKFPTRSKRIDVISRITFPLVFALFNL 449

Human   441 FYWIIYKIVRRED 453
            .||..|.....||
  Fly   450 VYWSTYLFREEED 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GLRA1	NP_001139512.1	LIC	7..446	CDD:273305	193/459 (42%)
		Strychnine-binding. /evidence=ECO:0000250\|UniProtKB:O93430	230..235		3/4 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	391..410		1/18 (6%)
GluClalpha	NP_001287408.1	LIC	3..455	CDD:273305	193/459 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	175	1.000	Domainoid score	I3644
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20083
Inparanoid	1	1.050	340	1.000	Inparanoid score	I2369
Isobase	1	0.950	-	0	Normalized mean entropy	S3705
OMA	1	1.010	-	-		QHG45222
OrthoDB	1	1.010	-	-		D276914at33208
OrthoFinder	1	1.000	-	-		FOG0000759
OrthoInspector	1	1.000	-	-		otm42124
orthoMCL	1	0.900	-	-		OOG6_101785
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4995
SonicParanoid	1	1.000	-	-		X271
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.960