Protein Alignment GLRA1 and SecCl

DIOPT Version :10

• Sequence 1: XP_047273061.1
• Gene: GLRA1 / 2741
• HGNCID: 4326
• Length: 465
• Species: Homo sapiens
• Sequence 2: NP_648984.2
• Gene: SecCl / 39949
• FlyBaseID: FBgn0036727
• Length: 509
• Species: Drosophila melanogaster
• Alignment Length: 518
• Identity: 145/518 - (27%)
• Similarity: 240/518 - (46%)
• Gaps: 98/518 - (18%)

Human    15 NLYQHEKEPSLTFCSPLFLLSLAASKEAEAARSAPKPMSPSDFLD--KLMGRTS---GYDARIRP 74
            ||:..|    :.:.:.:.:||:..|...:|.......|:.:..|.  :|:.|.:   .||...||
  Fly     3 NLHLSE----IFWITLILVLSIWTSVGVKAEEEECPSMADAGSLQQTQLIQRLTHVCRYDRLERP 63

Human    75 -----NFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEY-PDDSLDLDPSM 133
                 :.|..|:.|...|::....::....:.::::..|:.::.|.||||..: ..|::.....:
  Fly    64 FEYDSDGKRLPIVVKTRIYVYFLQNLNSDLLQFKMHALLQLRFQDKRLAYKAFNRSDNILGQKHL 128

Human   134 LDSIWKPDLFFANEKGAHFHEITTDNK--LLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTC 196
            .:.:|.|.:|||||:.:..  :.||.|  |..:|..|||:.|.|:..:|.|.|:.:.||.|.|.|
  Fly   129 SERLWLPHIFFANERESSI--LGTDEKDVLTSLSPEGNVIISTRMQASLYCWMNFQKFPFDQQFC 191

Human   197 IMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQF----------ILKEEKD-LRYCTKHYNTGK 250
            ...|||:.|..:|||.||:....:.....:.|.::          |::.:.| ||:..   ..|.
  Fly   192 STVLESWMYNTSDLILEWEPHTPISFDPEMRLTEYNMAQFWHNTTIVQSDGDNLRHGA---FAGN 253

Human   251 FTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSR 315
            ::.:....:|:|::|:||:..|:||::||.:||:|||:..||:|.|:.||.:|:|:..|.||...
  Fly   254 YSSLSFTVNLKREIGFYLLDYYLPSMMIVAISWVSFWLQADASPPRIMLGTSTMLSFITLSSSQS 318

Human   316 ASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQH--------------KELLRFRRKRR 366
            .:||||||:|..::|...|..|:|.:|:|:|.||.:.|:.              |..|..|..||
  Fly   319 KNLPKVSYIKVSEVWFLGCTFFIFGSLVEFAFVNTIWRRKENIELKKVNSKYIIKSTLTPRPARR 383

Human   367 H-----HKEDEA------------------GEGRFN--FSAY-GMGP-------ACLQAKDGISV 398
            .     ..|..|                  |.|..|  |:.| .:.|       .|.:| |.:|:
  Fly   384 QIGGSLSNESRARSCSSLDNIVSSTESVRNGNGTVNQGFNNYLTVHPNLPIIRTECAEA-DTVSI 447

Human   399 KGANNSN----------TTNPPPAPSKSPEEMRKLFIQRAKKIDKISRIGFPMAFLIFNMFYW 451
            ..|..:|          ...||...:.:|:|:       |..||:.||..||..||.||..||
  Fly   448 CSARTNNDHIVDVDKDKKDTPPTFTTMTPQEI-------AMWIDRRSRFLFPAMFLAFNALYW 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GLRA1	XP_047273061.1	LIC	24..454	CDD:273305	142/509 (28%)
SecCl	NP_648984.2	LIC	43..505	CDD:455710	136/474 (29%)