Protein Alignment BIN1 and RVS161

DIOPT Version :10

• Sequence 1: NP_647593.1
• Gene: BIN1 / 274
• HGNCID: 1052
• Length: 593
• Species: Homo sapiens
• Sequence 2: NP_009935.1
• Gene: RVS161 / 850367
• SGDID: S000000602
• Length: 265
• Species: Saccharomyces cerevisiae
• Alignment Length: 268
• Identity: 58/268 - (21%)
• Similarity: 112/268 - (41%)
• Gaps: 65/268 - (24%)

Human    19 QKKLTRAQEKVLQKLGKADETKDEQFEQCVQNFNKQLTEGTRLQKDLRTYLASVKAMHEASKKLN 83
            :|.:.||...|:.|  ..|:|.|::::...:.:......|..|||:.:.:|.|::|:..:...:.
Yeast     7 KKAINRAGHSVIIK--NVDKTIDKEYDMEERRYKVLQRAGEALQKEAKGFLDSLRAVTASQTTIA 69

Human    84 ECLQEVYEPDWPGRDEANKIA-----ENNDLLW--MDYHQKLVDQ-----------ALLTMDTYL 130
            |.:..:|       |::..:|     ..|..|.  .|:..:.|.|           .:....||
Yeast    70 EVISNLY-------DDSKYVAGGGYNVGNYYLQCVQDFDSETVKQLDGPLRETVLDPITKFSTY- 126

Human   131 GQFPDIKSRIAKRGRKLVDYDSARHHYESLQTAKKKDEAKIAKPVSLLEKAAPQWCQGKLQAHLV 195
              |.:|:..|.||..|..|:|:|:.....|.....||.:|:.:
Yeast   127 --FKEIEEAIKKRDHKKQDFDAAKAKVRRLVDKPAKDASKLPR---------------------- 167

Human   196 AQTNLLRNQAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENF----HKEM 256
                     ||:||..|:.:||.:|..|:.|||.|.:.||.::..:|:::..::..|    :..:
Yeast   168 ---------AEKELSLAKDIFENLNNQLKTELPQLVSLRVPYFDPSFEALIKIQLRFCTDGYTRL 223

Human   257 SKLNQNLN 264
            :::.|.|:
Yeast   224 AQIQQYLD 231

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BIN1	NP_647593.1	Interaction with BIN2. /evidence=ECO:0000269|PubMed:10903846	2..122		24/120 (20%)
		BAR_Amphiphysin_I_II	31..272	CDD:153295	54/256 (21%)
		PHA03247	<276..507	CDD:223021
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	280..354
		Clathrin-binding	378..421
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	400..488
		SH3_Bin1	521..592	CDD:213015
RVS161	NP_009935.1	BAR_Rvs161p	18..243	CDD:153275	54/257 (21%)