Protein Alignment BIN1 and bin1a

DIOPT Version :10

• Sequence 1: NP_647593.1
• Gene: BIN1 / 274
• HGNCID: 1052
• Length: 593
• Species: Homo sapiens
• Sequence 2: XP_009302754.1
• Gene: bin1a / 563561
• ZFINID: ZDB-GENE-070912-715
• Length: 582
• Species: Danio rerio
• Alignment Length: 627
• Identity: 331/627 - (52%)
• Similarity: 416/627 - (66%)
• Gaps: 80/627 - (12%)

Human     1 MAE--MGSKGVTAGKIASNVQKKLTRAQEKVLQKLGKADETKDEQFEQCVQNFNKQLTEGTRLQK 63
            |||  || |||:|||||||||||:|||||||:|||||||||||..||:.|.||||||.|||:|||
Zfish     1 MAELPMG-KGVSAGKIASNVQKKITRAQEKVMQKLGKADETKDLAFEEGVINFNKQLVEGTKLQK 64

Human    64 DLRTYLASVKAMHEASKKLNECLQEVYEPDWPGRDEANKIAENNDLLWMDYHQKLVDQALLTMDT 128
            |||.||.:||||||:|::|.|||.::||.:|.||.:.:.:.|::||||.|:||||||.||::|||
Zfish    65 DLRAYLTAVKAMHESSRRLYECLDDMYETEWYGRKKMDAVVEDSDLLWTDFHQKLVDHALISMDT 129

Human   129 YLGQFPDIKSRIAKRGRKLVDYDSARHHYESLQTAKKKDEAKIAKPVSLLEKAAPQWCQGKLQAH 193
            |||||||||:|||||.|||||:|||||::.::...|||:..||.||.||||:|||.|.||.|.||
Zfish   130 YLGQFPDIKARIAKRDRKLVDFDSARHNFAAVNKGKKKEGVKITKPASLLERAAPSWAQGILSAH 194

Human   194 LVAQTNLLRNQAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENFHKEMSK 258
            .||||:|.|:||||||.:|||||||:|:|||||||||||||||||||||||:|||||.||:||.|
Zfish   195 NVAQTSLSRSQAEEELERAQKVFEEINIDLQEELPSLWNSRVGFYVNTFQSVAGLEEKFHREMGK 259

Human   259 LNQNLNDVLVGLEKQHGSNTFTVKAQPSDNAPAKGNKSPSPPDGSPAATPEIRVNHEPEPAGGAT 323
            :||||.|.|..||.|    ..|.|........:...||....|          .||...|.|
Zfish   260 INQNLYDTLDKLENQ----DMTSKTGSQGVRTSTAQKSERTQD----------ANHTLSPGG--- 307

Human   324 PGATLPKSPSQLRKGPPVPPPPKHTPSKEVKQEQILSLFEDTFVPEISVTTPSQFEAPGPFSEQA 388
            |.| :|||||:||  |.||||||.||||::|||.|::|||:...|.||||:|::::||.    ..
Zfish   308 PPA-IPKSPSKLR--PAVPPPPKVTPSKDLKQESIINLFEEAATPNISVTSPTEYDAPA----TG 365

Human   389 SLLDLDFDPLPPVTSPVKAPTPSGQSIPWDLWEPTESPA---------GSLPSGEPSAAEGTFAV 444
            :|||:|.|.|...|      ||:.|:  ||.||..:..|         |:.|.......:||.|
Zfish   366 NLLDMDLDSLQAAT------TPAAQT--WDSWEQGDKEAEVPQTWDDDGTQPVRSGWEDDGTQA- 421

Human   445 SWPSQTAEP--GPA-----QPAEASEVAGGTQPAA----------------GAQEPGETAASEAA 486
            :|....::|  .||     ..|:..:...|:||..                |||....||.:|.|
Zfish   422 TWDDDGSQPVRAPAAYPTWDDADDDKEDDGSQPVQANDNDPTQETQGWDDDGAQTAETTAVTEEA 486

Human   487 SSSLPAVVVETFPATVNGTV-EGGSGAGRLDLPPGFMFKVQAQHDYTATDTDELQLKAGDVVLVI 550
            :::.|          |:.|| |.......:::|..|:|||:|.|||.|||:|||:|||||||||:
Zfish   487 AAAEP----------VSETVQESAESPESVEMPESFLFKVKAMHDYNATDSDELELKAGDVVLVV 541

Human   551 PFQNPEEQDEGWLMGVKESDWNQHKELEKCRGVFPENFTERV 592
            .::||::||:||||||||:||.|.|:|.| :||||||||:|:
Zfish   542 NYENPDDQDDGWLMGVKEADWIQQKDLGK-KGVFPENFTQRM 582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BIN1	NP_647593.1	Interaction with BIN2. /evidence=ECO:0000269|PubMed:10903846	2..122		84/121 (69%)
		BAR_Amphiphysin_I_II	31..272	CDD:153295	168/240 (70%)
		PHA03247	<276..507	CDD:223021	83/263 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	280..354		29/73 (40%)
		Clathrin-binding	378..421		14/42 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	400..488		29/119 (24%)
		SH3_Bin1	521..592	CDD:213015	49/70 (70%)
bin1a	XP_009302754.1	BAR	32..272	CDD:472257	167/239 (70%)
		SH3	512..582	CDD:473055	49/70 (70%)