Protein Alignment BIN1 and bin1

DIOPT Version :10

• Sequence 1: NP_647593.1
• Gene: BIN1 / 274
• HGNCID: 1052
• Length: 593
• Species: Homo sapiens
• Sequence 2: NP_989231.2
• Gene: bin1 / 394839
• XenbaseID: XB-GENE-979735
• Length: 508
• Species: Xenopus tropicalis
• Alignment Length: 615
• Identity: 370/615 - (60%)
• Similarity: 413/615 - (67%)
• Gaps: 133/615 - (21%)

Human     1 MAEMGSKGVTAGKIASNVQKKLTRAQEKVLQKLGKADETKDEQFEQCVQNFNKQLTEGTRLQKDL 65
            |||:| |||:||||||||||||||||||||||||||||||||||||||||||||||||::|||||
 Frog     1 MAELG-KGVSAGKIASNVQKKLTRAQEKVLQKLGKADETKDEQFEQCVQNFNKQLTEGSKLQKDL 64

Human    66 RTYLASVKAMHEASKKLNECLQEVYEPDWPGRDEANKIAENNDLLWMDYHQKLVDQALLTMDTYL 130
            |.|||||||||||||||.|||.:|||||||||:|.|||||||||||.|||:||||||||||||||
 Frog    65 RAYLASVKAMHEASKKLTECLLDVYEPDWPGREETNKIAENNDLLWTDYHEKLVDQALLTMDTYL 129

Human   131 GQFPDIKSRIAKRGRKLVDYDSARHHYESLQTAKKKDEAKIAKPVSLLEKAAPQWCQGKLQAHLV 195
            ||||||||||||||||||||||||||:||||.||||||.||||
 Frog   130 GQFPDIKSRIAKRGRKLVDYDSARHHFESLQNAKKKDETKIAK---------------------- 172

Human   196 AQTNLLRNQAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENFHKEMSKLN 260
                     |||||:|.||||||||.|||||||||||||||||||||||||||||||||||.||:
 Frog   173 ---------AEEELLKTQKVFEEMNADLQEELPSLWNSRVGFYVNTFQSIAGLEENFHKEMGKLH 228

Human   261 QNLNDVLVGLEKQHG---SNTFTVKAQP---------------SDNAPAKGNKSPSPP--DGSPA 305
            |.||||:|.||.:.|   :|:.:||.||               |:..|.|.|||||||  ||.||
 Frog   229 QGLNDVMVTLESEQGNLSTNSSSVKVQPRKKMNLFSRLRIKKGSETTPTKMNKSPSPPATDGPPA 293

Human   306 ATPEIRVNHEPE----PAGGATPGATLPKSPSQLRKGPPVPPPPKHTPSKEVKQEQILSLFEDTF 366
            .:....|||:.|    || ..||...:.|||||||:|||||||||.||||:.|||.|||||:|:|
 Frog   294 VSETKAVNHDFEERSAPA-EETPSVVISKSPSQLRRGPPVPPPPKVTPSKDFKQENILSLFDDSF 357

Human   367 VPEISVTTPSQFEAPGPFSEQASLLDLDFDPLPPVTSPVKAPTPSGQSIPWDLWEPTESPAGSLP 431
            |||||||||||...|.|            .|: |||.|.|..|......|         |:..:|
 Frog   358 VPEISVTTPSQPVEPAP------------APV-PVTEPAKKETEVKLESP---------PSEEVP 400

Human   432 SGEPSAAEGTFAVSWPSQTAEPGPAQPAEASEVAGGTQPAAGAQEPGETAASEAASSSLPAVVVE 496
            ...|                                                    |||||||||
 Frog   401 DKSP----------------------------------------------------SSLPAVVVE 413

Human   497 TFPATVNGTVEGGSGAGRLDLPPGFMFKVQAQHDYTATDTDELQLKAGDVVLVIPFQNPEEQDEG 561
            ||.||||||||  |...:.::||||::||:|||||.:||:|||.|||||:|||..|:||:|||:|
 Frog   414 TFSATVNGTVE--SSPPKAEMPPGFLYKVRAQHDYASTDSDELNLKAGDMVLVTQFENPDEQDDG 476

Human   562 WLMGVKESDWNQHKELEKCRGVFPENFTER 591
            ||||:||:||.|:|..|:.||||||||||:
 Frog   477 WLMGIKETDWLQNKPFEQHRGVFPENFTEK 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BIN1	NP_647593.1	Interaction with BIN2. /evidence=ECO:0000269|PubMed:10903846	2..122		106/119 (89%)
		BAR_Amphiphysin_I_II	31..272	CDD:153295	188/240 (78%)
		PHA03247	<276..507	CDD:223021	98/251 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	280..354		46/94 (49%)
		Clathrin-binding	378..421		10/42 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	400..488		10/87 (11%)
		SH3_Bin1	521..592	CDD:213015	49/71 (69%)
bin1	NP_989231.2	None