Protein Alignment BIN1 and Bin1

DIOPT Version :10

• Sequence 1: NP_647593.1
• Gene: BIN1 / 274
• HGNCID: 1052
• Length: 593
• Species: Homo sapiens
• Sequence 2: XP_006526041.1
• Gene: Bin1 / 30948
• MGIID: 108092
• Length: 603
• Species: Mus musculus
• Alignment Length: 608
• Identity: 562/608 - (92%)
• Similarity: 573/608 - (94%)
• Gaps: 22/608 - (3%)

Human     1 MAEMGSKGVTAGKIASNVQKKLTRAQEKVLQKLGKADETKDEQFEQCVQNFNKQLTEGTRLQKDL 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse     1 MAEMGSKGVTAGKIASNVQKKLTRAQEKVLQKLGKADETKDEQFEQCVQNFNKQLTEGTRLQKDL 65

Human    66 RTYLASVKAMHEASKKLNECLQEVYEPDWPGRDEANKIAENNDLLWMDYHQKLVDQALLTMDTYL 130
            |||||||||||||||||:|||||||||:|||||||||||||||||||||||||||||||||||||
Mouse    66 RTYLASVKAMHEASKKLSECLQEVYEPEWPGRDEANKIAENNDLLWMDYHQKLVDQALLTMDTYL 130

Human   131 GQFPDIKSRIAKRGRKLVDYDSARHHYESLQTAKKKDEAKIAKPVSLLEKAAPQWCQGKLQAHLV 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   131 GQFPDIKSRIAKRGRKLVDYDSARHHYESLQTAKKKDEAKIAKPVSLLEKAAPQWCQGKLQAHLV 195

Human   196 AQTNLLRNQAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENFHKEMSKLN 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   196 AQTNLLRNQAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENFHKEMSKLN 260

Human   261 QNLNDVLVGLEKQHGSNTFTVKAQP---------------SDNAPAKGNKSPS-PPDGSPAATPE 309
            ||||||||.||||||||||||||||               |||||.||||||| |||||||||||
Mouse   261 QNLNDVLVSLEKQHGSNTFTVKAQPRKKTKLFSRLRRKKNSDNAPEKGNKSPSPPPDGSPAATPE 325

Human   310 IRVNHEPEPAGGATPGATLPKSPSQLRKGPPVPPPPKHTPSKEVKQEQILSLFEDTFVPEISVTT 374
            ||||||||||.||:||||:||||||||||||||||||||||||:|||||||||:|.|||||||||
Mouse   326 IRVNHEPEPASGASPGATIPKSPSQLRKGPPVPPPPKHTPSKEMKQEQILSLFDDAFVPEISVTT 390

Human   375 PSQFEAPGPFSEQASLLDLDFDPLPPVTSPVKAPTPSGQSIPWDLWEPTESPAGSLPSGEPSAAE 439
            |||||||||||||||||||||:|||||.|||||||||||||||||||||||.||.|||||||:||
Mouse   391 PSQFEAPGPFSEQASLLDLDFEPLPPVASPVKAPTPSGQSIPWDLWEPTESQAGILPSGEPSSAE 455

Human   440 GTFAVSWPSQTAEPGPAQPAEASEVAGGTQPAAGAQEPGETAASEAASSSLPAVVVETFPATVNG 504
            |:|||:|||||||||||||||||||.|      |||||||||||||.||||||||||||.|||||
Mouse   456 GSFAVAWPSQTAEPGPAQPAEASEVVG------GAQEPGETAASEATSSSLPAVVVETFSATVNG 514

Human   505 TVEGGSGAGRLDLPPGFMFKVQAQHDYTATDTDELQLKAGDVVLVIPFQNPEEQDEGWLMGVKES 569
            .|||.:|.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   515 AVEGSAGTGRLDLPPGFMFKVQAQHDYTATDTDELQLKAGDVVLVIPFQNPEEQDEGWLMGVKES 579

Human   570 DWNQHKELEKCRGVFPENFTERV 592
            |||||||||||||||||||||||
Mouse   580 DWNQHKELEKCRGVFPENFTERV 602

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BIN1	NP_647593.1	Interaction with BIN2. /evidence=ECO:0000269|PubMed:10903846	2..122		117/119 (98%)
		BAR_Amphiphysin_I_II	31..272	CDD:153295	237/240 (99%)
		PHA03247	<276..507	CDD:223021	206/246 (84%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	280..354		69/89 (78%)
		Clathrin-binding	378..421		40/42 (95%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	400..488		73/87 (84%)
		SH3_Bin1	521..592	CDD:213015	70/70 (100%)
Bin1	XP_006526041.1	BAR_Amphiphysin_I_II	31..272	CDD:153295	237/240 (99%)
		KREPA	<378..>512	CDD:483960	121/139 (87%)
		SH3_Bin1	531..602	CDD:213015	70/70 (100%)