Protein Alignment BIN1 and hob3

DIOPT Version :10

• Sequence 1: NP_647593.1
• Gene: BIN1 / 274
• HGNCID: 1052
• Length: 593
• Species: Homo sapiens
• Sequence 2: NP_595489.1
• Gene: hob3 / 2541160
• PomBaseID: SPBC725.09C
• Length: 264
• Species: Schizosaccharomyces pombe
• Alignment Length: 265
• Identity: 57/265 - (21%)
• Similarity: 108/265 - (40%)
• Gaps: 67/265 - (25%)

Human    19 QKKLTRAQEKVLQKLGKADETKDEQFEQCVQNFNKQLTEGTRLQKDLRTYLASVKAMHEASKKLN 83
            :|.:.||...|:.|.|..:.|.|.:||...:.:....:...:|||:.:.||.:::||..:..::.
pombe     7 KKAVNRAGTSVMMKTGHVERTVDREFETEERRYRTMESAAKKLQKEAKGYLDALRAMTASQTRIA 71

Human    84 ECLQEVYEPDWPGRDEANKIAENNDLLWMDYHQKLVDQALLTMDT------------------YL 130
            ..:...| .|...:|..:.           |::::|:.  |..||                  :.
pombe    72 NTIDAFY-GDAGSKDGVSA-----------YYRQVVED--LDADTVKELDGPFRTTVLDPISRFC 122

Human   131 GQFPDIKSRIAKRGRKLVDYDSARHHYESLQTAKKKDEAKIAKPVSLLEKAAPQWCQGKLQAHLV 195
            ..||||.:.|.||..||:|:|:.|...:.|......|..|:.:
pombe   123 SYFPDINAAITKRNHKLLDHDAMRAKVQKLVDKPSNDTTKLPR---------------------- 165

Human   196 AQTNLLRNQAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENF----HKEM 256
                     .|:|...|::|:|.:|..|..|||.|...||.:...:|:::..::..|    :::|
pombe   166 ---------TEKEAAMAKEVYETLNNQLVSELPQLIALRVPYLDPSFEALVKIQLRFCREGYEKM 221

Human   257 SKLNQ 261
            :::.|
pombe   222 AQVQQ 226

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BIN1	NP_647593.1	Interaction with BIN2. /evidence=ECO:0000269|PubMed:10903846	2..122		22/102 (22%)
		BAR_Amphiphysin_I_II	31..272	CDD:153295	53/253 (21%)
		PHA03247	<276..507	CDD:223021
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	280..354
		Clathrin-binding	378..421
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	400..488
		SH3_Bin1	521..592	CDD:213015
hob3	NP_595489.1	BAR_Rvs161p	20..241	CDD:153275	53/252 (21%)