Protein Alignment BIN1 and Bin1

DIOPT Version :10

• Sequence 1: NP_647593.1
• Gene: BIN1 / 274
• HGNCID: 1052
• Length: 593
• Species: Homo sapiens
• Sequence 2: XP_006254558.2
• Gene: Bin1 / 117028
• RGDID: 621786
• Length: 603
• Species: Rattus norvegicus
• Alignment Length: 608
• Identity: 560/608 - (92%)
• Similarity: 572/608 - (94%)
• Gaps: 22/608 - (3%)

Human     1 MAEMGSKGVTAGKIASNVQKKLTRAQEKVLQKLGKADETKDEQFEQCVQNFNKQLTEGTRLQKDL 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat     1 MAEMGSKGVTAGKIASNVQKKLTRAQEKVLQKLGKADETKDEQFEQCVQNFNKQLTEGTRLQKDL 65

Human    66 RTYLASVKAMHEASKKLNECLQEVYEPDWPGRDEANKIAENNDLLWMDYHQKLVDQALLTMDTYL 130
            |||||||||||||||||:|||||||||:|||||||||||||||||||||||||||||||||||||
  Rat    66 RTYLASVKAMHEASKKLSECLQEVYEPEWPGRDEANKIAENNDLLWMDYHQKLVDQALLTMDTYL 130

Human   131 GQFPDIKSRIAKRGRKLVDYDSARHHYESLQTAKKKDEAKIAKPVSLLEKAAPQWCQGKLQAHLV 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   131 GQFPDIKSRIAKRGRKLVDYDSARHHYESLQTAKKKDEAKIAKPVSLLEKAAPQWCQGKLQAHLV 195

Human   196 AQTNLLRNQAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENFHKEMSKLN 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   196 AQTNLLRNQAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENFHKEMSKLN 260

Human   261 QNLNDVLVGLEKQHGSNTFTVKAQP---------------SDNAPAKGNKSPS-PPDGSPAATPE 309
            ||||||||.||||||||||||||||               ||:||.||||||| |||||||||||
  Rat   261 QNLNDVLVSLEKQHGSNTFTVKAQPRKKTKLFSRLRRKKNSDSAPEKGNKSPSPPPDGSPAATPE 325

Human   310 IRVNHEPEPAGGATPGATLPKSPSQLRKGPPVPPPPKHTPSKEVKQEQILSLFEDTFVPEISVTT 374
            ||||||||||.||:||||:||||||||||||||||||||||||:|||||||||:|.|||||||||
  Rat   326 IRVNHEPEPASGASPGATIPKSPSQLRKGPPVPPPPKHTPSKEMKQEQILSLFDDAFVPEISVTT 390

Human   375 PSQFEAPGPFSEQASLLDLDFDPLPPVTSPVKAPTPSGQSIPWDLWEPTESPAGSLPSGEPSAAE 439
            |||||||||||||||||||||:|||||.|||||||||||||||||||||||.||.|||||||:||
  Rat   391 PSQFEAPGPFSEQASLLDLDFEPLPPVASPVKAPTPSGQSIPWDLWEPTESQAGVLPSGEPSSAE 455

Human   440 GTFAVSWPSQTAEPGPAQPAEASEVAGGTQPAAGAQEPGETAASEAASSSLPAVVVETFPATVNG 504
            |:|||:|||||||||||||||||||.|||      |||||||||||.||||||||||||.|||||
  Rat   456 GSFAVAWPSQTAEPGPAQPAEASEVVGGT------QEPGETAASEATSSSLPAVVVETFSATVNG 514

Human   505 TVEGGSGAGRLDLPPGFMFKVQAQHDYTATDTDELQLKAGDVVLVIPFQNPEEQDEGWLMGVKES 569
            .|||.:..|||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   515 AVEGSTTTGRLDLPPGFMFKVQAQHDYTATDTDELQLKAGDVVLVIPFQNPEEQDEGWLMGVKES 579

Human   570 DWNQHKELEKCRGVFPENFTERV 592
            |||||||||||||||||||||||
  Rat   580 DWNQHKELEKCRGVFPENFTERV 602

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BIN1	NP_647593.1	Interaction with BIN2. /evidence=ECO:0000269|PubMed:10903846	2..122		117/119 (98%)
		BAR_Amphiphysin_I_II	31..272	CDD:153295	237/240 (99%)
		PHA03247	<276..507	CDD:223021	205/246 (83%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	280..354		68/89 (76%)
		Clathrin-binding	378..421		40/42 (95%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	400..488		73/87 (84%)
		SH3_Bin1	521..592	CDD:213015	70/70 (100%)
Bin1	XP_006254558.2	BAR_Amphiphysin_I_II	31..272	CDD:153295	237/240 (99%)
		PRK12323	<331..505	CDD:481241	158/179 (88%)
		PRK14959	<415..>488	CDD:184923	65/78 (83%)
		SH3_Bin1	531..602	CDD:213015	70/70 (100%)