DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pign and CG6790

DIOPT Version :9

Sequence 1:	NP_038812.2	Gene:	Pign / 27392	MGIID:	1351629	Length:	931	Species:	Mus musculus
Sequence 2:	NP_650087.2	Gene:	CG6790 / 41388	FlyBaseID:	FBgn0037915	Length:	897	Species:	Drosophila melanogaster

Alignment Length:	951	Identity:	224/951 - (23%)
Similarity:	412/951 - (43%)	Gaps:	195/951 - (20%)

- Green bases have known domain annotations that are detailed below.

Mouse     9 LLIHFVFFASIFDIYFTSPLVHGMTPQFTPL----PPPAKRLVLFVADGLRADTLYELDEDGNSR 69
            :|:|.:....|..|::.|..:..:.||.|.|    ||.|.|||:|:.:|||||||:   .|..|.
  Fly    48 VLVHLLLLICIMRIFYQSGPLSQLEPQKTLLDMGVPPAADRLVVFLLEGLRADTLF---SDNCSG 109

Mouse    70 APFIRNVIMHEGSWGVSHTRVPTESRPGHVALIAGFYEDVSAVAKGWKENPV-------EFDSLF 127
            |.:||::|:.:|..|:|.|.|||.:|...|||.|||             ||:       .||::|
  Fly   110 AVYIRDIILRQGLVGISKTSVPTLTRSAEVALFAGF-------------NPMPSILPTSNFDTIF 161

Mouse   128 NESKYTWSWGSPDILPMFAKGASGDHVYTYSYDAQREDFGAHDATKLDTWVFDKVKDFFDAAR-- 190
            |.:.            .|.|||                             |.:.....|..|
  Fly   162 NRTL------------AFDKGA-----------------------------FLRFSHLSDLRRRL 185

Mouse   191 NNQSLFTKV-NEEKVVFFLHLLGIDTNGHAHRPSSREYKDNIKKVDDGVKEIVSIFKHFYGDDGK 254
            ..::...|: ...|:|..::|..:   |.| .|....::..:......:::...:.:..: :|.|
  Fly   186 TKRACLEKLWYANKLVMLVNLAEV---GGA-SPLDIGFQMKLHNTQRNIRDAYELIEATF-NDSK 245

Mouse   255 TAFIFTSDHGMTDWGSHGAGHPSETLTPFVTWGAGIK-FPQNVSAQQYDDEFLKEWRLEN---WK 315
            ||:::||.||:|.:||||.|...|...||:.||||:| ..:|:::         ::.|.|   .:
  Fly   246 TAYLYTSAHGLTYFGSHGGGSDEEREAPFLLWGAGVKHVTENITS---------DFVLNNGVGMQ 301

Mouse   316 RRDVNQADIAPLMASLIGVPFPLNSVGILPVGYLNNTGLFKAESMFTNAVQILEQFKVKMTQKKE 380
            ...::|..:||||::|||:|.|:|::.|||.||:..:..:..:|:..||:|:|.|.|..:...:.
  Fly   302 LHKLDQIQLAPLMSALIGLPPPVNNLAILPQGYMKVSREYARKSVHLNALQLLTQAKAIIRLHER 366

Mouse   381 ATLPFLFTPFKLLSDSQQLDILRKARSYIKQEKFDEVVSL---------CEELIDLALRGLSYYH 436
            ...      .|.|...:.|| |::...|  |.:.|.::.:         ....|.:||:.|.:||
  Fly   367 GVF------HKWLPKDKDLD-LQQIAYY--QNQMDHLLDMGWRSKALETSTLAIKVALKSLKFYH 422

Mouse   437 TYDRLFLGINVAVGFVGWMSYTSLLIIKSHSNI--PKGTRKEGKKPHCLLLYSFIAT-GVLVACF 498
            .|..:.|.:...:..:||..|.   ::|...|:  |...|: |....|.:   |:|: |:|:...
  Fly   423 NYYHIPLVVTTVLALLGWQFYQ---LVKLSQNVMAPHYMRR-GYLTWCTI---FLASLGLLLGEM 480

Mouse   499 LMIQACPWTYYVYCLLPVPIW---YAVLREHEVIQDLVESLLTFPRSHFVAYLLVFTLG-IEVLV 559
            :.:|..|:...:..::|..:|   .|.|.::       ...:..|..|     |.:.:| ..|::
  Fly   481 VFLQWAPFMTVICLVVPFGVWCMTLAALPQN-------GGWIFEPLKH-----LRWIVGPAAVMI 533

Mouse   560 LSFFYRYMLTAGLIVFAGWPFLTQLWTRAKITFLSWAFFSLLLAVFPLMPVVGRKPNLSLVMGAG 624
            .|.:....|:...|:..|: :..:.|......||:|....|||..|     :..:..:.::|...
  Fly   534 ASIYCNCPLSLAYILCVGF-YNRRGWLHPSPKFLAWLALVLLLGGF-----LWSQKGMQILMTTN 592

Mouse   625 FLVLLLSLAVVTTL---------GKRNIKLVKGELLVLLLQMLSTVLSMYVVYSTHHSLLKKEG- 679
            :.|:|.:::::..:         .|..:.::.|.:|.:      ..:.::         ||:.|
  Fly   593 YRVVLQAISMLVVIVRPCVLNENHKWKVWVINGGILFV------AAIGIF---------LKEMGK 642

Mouse   680 -LPLMNQIVSWATLASSLVA-PLLSSTALSQRLASILLSLMSTYLLLSTGYEALFP--LVLSCLM 740
             :||.....:||.|..:..: |..|.|....||..|..:|::.::|||..|.:||.  |::.
  Fly   643 PVPLYLFAANWAYLIYAFASVPCSSRTTPQSRLELIRFNLLTLHVLLSDSYVSLFAQGLIIE--- 704

Mouse   741 FVWIQVEQETLQQPGVSCKQKLTSIQFTCDTDI-----AQFRQLCPDDIRRAFFLVFFLLTAFFG 800
                       .|.|:...:|...    .|.|:     ::..|:|   .|.|..::.:...:.||
  Fly   705 -----------YQMGLEVHEKFKE----ADEDVKILTSSKHLQMC---YRFAVSILLYFYASLFG 751

Mouse   801 TGNIASINSFDLASVYCFLTVFSPFMMGALMMWKILIPFVLVMCAFEAVQITTQLSSKGLFLVVL 865
            ||:.....::...|...||...|..::..|::..:|||.:::|.:..|:....:...:.:|..::
  Fly   752 TGHWVGGFTYLANSARLFLPDSSSGLVPLLVLIHLLIPSIVIMASVVALSSFGRQQIRTIFSSLM 816

Mouse   866 IISDIMALHFFFLVKDSGSWLDIGTSISHYVIVMSMTIFLV 906
            :|.:.:.|.|...|..:..|.....|:.| .::..:|:.|:
  Fly   817 LICNAVVLFFVVFVPHNAYWPMAHPSVVH-ALLAQLTVILI 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pign	NP_038812.2	GPI_EPT_1	40..345	CDD:293744	91/318 (29%)
Pign	NP_038812.2	PigN	431..884	CDD:368221	97/478 (20%)
CG6790	NP_650087.2	GPI_EPT_1	83..331	CDD:293744	91/318 (29%)
CG6790	NP_650087.2	PigN	418..821	CDD:282796	94/463 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850135
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1524
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1579
OMA	1	1.010	-	-		QHG55072
OrthoDB	1	1.010	-	-		D141925at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12250
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.810