DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mmel1 and Nepl4

DIOPT Version :9

Sequence 1:	NP_038811.2	Gene:	Mmel1 / 27390	MGIID:	1351603	Length:	766	Species:	Mus musculus
Sequence 2:	NP_609019.1	Gene:	Nepl4 / 33889	FlyBaseID:	FBgn0031805	Length:	652	Species:	Drosophila melanogaster

Alignment Length:	738	Identity:	155/738 - (21%)
Similarity:	273/738 - (36%)	Gaps:	194/738 - (26%)

- Green bases have known domain annotations that are detailed below.

Mouse    88 ILENMDQSRNPCENFYQYACGGWLRHHVIPETNSRYSVFDILRDELEVILKGVLEDSTSQH-RPA 151
            ::..:|..:||||:||.||||.|...|....|.:..|...|.|...::.|:.:...|..:: .|.
  Fly    50 LMSYVDSEKNPCEDFYAYACGKWRAKHGSHTTATMISESQINRQYEDLFLQLLRNPSAPEYGYPM 114

Mouse   152 VEKAKTLYRSCMNQSVIEKRDSEPLLSVLKMVGGWPVAMDKWNETMGLKWELERQ-LAVLNSQFN 215
            ..|....|:||:   .:||.|....:.:                       |:|. ||.|||...
  Fly   115 FAKVLAHYQSCI---ALEKPDLRRYIEL-----------------------LDRDLLASLNSTHW 153

Mouse   216 RRVLIDL--------FI-----WNDDQNSSRHVIYIDQPTLGMPSREYYFQEDNNHKVRKAYLEF 267
            ..:|..|        ::     |   .|::.|:|::      :|        .|.|    ..|..
  Fly   154 MHLLAALGRYGYHGHYVQVEVRW---YNATHHMIFL------LP--------HNRH----LNLSL 197

Mouse   268 MTSVATMLRKDQNLSKESAMVREEMAEVLELETHLANATVPQEKRHDVTALYHRMDLMELQERFG 332
            ...:...|.:|.:.......::|:..   .||.:|.....|...  |.|...:.:|    |.|..
  Fly   198 TQDIYDALSQDGSSWPPLHQLQEQFR---SLEQNLVRLAKPHSA--DDTFRNYSLD----QIRTE 253

Mouse   333 LKGFNWTLFIQNVLS-SVEVELFPDEEVVVYGIPYLENLEDIIDSYSARTMQNYLVWRLVLDRIG 396
            :.|.:|...::..|. ||     |...  |:.:..|:.:|.:::..:  |:...|:.|..|.|.
  Fly   254 VPGLHWDEALRTQLGRSV-----PGNH--VFQVDDLDAIEGLVEYLN--TVDTLLLNRYSLARF- 308

Mouse   397 SLSQRFKEARVDYRKALYGTTVEEVRWRECVSYVNSNMESAVGSLYIKRAFSKDSKSTVRELIEK 461
             ||...:   :.:.......:.:..|.|.|:.::..::...:..:|.:..:|:  :....||:
  Fly   309 -LSHLLE---LPHNPLATWESGQRSRGRNCIRHMRRSVYLPMNYVYERSFYSR--RRHADELV-- 365

Mouse   462 IRSVFVDNLDELNW--------MDEESKKKAQEKAMNIREQIG-YPDYILEDNNKHLDEEYS-SL 516
            |.|||.....:|..        :.::..|..|.|...:|..:| .|..:.|......|..:| ..
  Fly   366 IHSVFQQLQSQLELRVQHNAFNLSQDLVKSLQAKVHQMRINVGNLPPNVTEQFYWDSDRRWSVGR 430

Mouse   517 TFYED-----LYFENGLQNLKNNAQRSLKKLREKVDQNLWIIGAAVVNAFYSPNRNQIVFPAGI- 575
            .|||:     ||:...:.:|::::        ::.::::|          ||.|.:...||..|
  Fly   431 DFYENHLNSLLYYYTLVADLESSS--------DQEERDIW----------YSFNMHTPEFPDNID 477

Mouse   576 ------------------LQPPFFSKDQPQSLNFGGIGMVIGHEITHGFDDNGRNFDKNGNMLDW 622
                              ::.|||..:...:|.:|.:...:||||.|.||.:..::|..||:
  Fly   478 ATPYFYCLGNIIFVPYSYVKRPFFDANFWPALLYGDLANTLGHEIMHAFDTDLVDYDAQGNL--- 539

Mouse   623 WSNFSARHFQQQSQCMIYQYGNFSWELADNQNVNG--------FSTLGENIADNGGVRQAYKAY- 678
                                .|||.:|.:.:..||        ...|.|..:|..|.|.|.:.|
  Fly   540 --------------------RNFSDQLGEVELYNGAVGCLNSSAVMLNERTSDVSGSRLAMQTYG 584

Mouse   679 LRWLADGGKDQRLPGLNLTYAQLFFINYAQVWCGSYRPEFAVQSIKTDVHSPLKYRVLGSLQNLP 743
            ..||...|.           .:|:|:.:|..:||....::         |.....|:..:|..:|
  Fly   585 GDWLTRSGN-----------GRLYFLQFAHFFCGDEGDQY---------HDSGSQRLNYALGQVP 629

Mouse   744 GFSEAFHCPRGSPMHPMKRCRIW 766
            .|:|.|.|..||.|....:|..|
  Fly   630 QFAEVFRCHVGSGMTSADQCPFW 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmel1	NP_038811.2	PepO	89..766	CDD:226118	154/735 (21%)
Mmel1	NP_038811.2	M13	97..764	CDD:189000	152/725 (21%)
Nepl4	NP_609019.1	PepO	51..643	CDD:226118	152/726 (21%)
Nepl4	NP_609019.1	GluZincin	59..649	CDD:301352	152/724 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020