DRSC/TRiP Functional Genomics Resources

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Protein Alignment GLI4 and Kr-h1

DIOPT Version :9

Sequence 1:NP_612474.1 Gene:GLI4 / 2738 HGNCID:4320 Length:376 Species:Homo sapiens
Sequence 2:NP_477466.1 Gene:Kr-h1 / 33861 FlyBaseID:FBgn0266450 Length:845 Species:Drosophila melanogaster


Alignment Length:401 Identity:133/401 - (33%)
Similarity:176/401 - (43%) Gaps:50/401 - (12%)


- Green bases have known domain annotations that are detailed below.


Human    13 VPSP-------VSLSSPGTPGTQHH----------EPQLHLHGHQHGSPGS---SPKVLSQPSDL 57
            ||.|       |.|..|.:.|.|.|          :.||.|. .||.....   |.::..|....
  Fly    79 VPPPLTATTTSVGLGVPPSGGQQEHFELLQTPQQRQMQLQLQ-DQHQQEQQQFVSYQLAIQQHQK 142

Human    58 DLQDVEEVEIGRDTFWPDSEPKPEQAPRSPGSQAPDEGAGGALRSLLR----SLP--RRARCSAG 116
            ..|..:...|....  |.:.|..::....|....|   |..|:.|.:|    |.|  :..:|...
  Fly   143 QQQQQQHESITNAA--PTAAPSAQRIKTEPVGGFP---ASAAVVSQVRKPSASKPQFKCDQCGMT 202

Human   117 FGPES--SAERPAGQPPGAVPCAQPRGAWRVTLVQQAA-----AG-PEGAPERAAELGVNFGRSR 173
            ||.:|  ::...:......:......||.....|..||     || |.|.|:....      :..
  Fly   203 FGSKSAHTSHTKSHSKNQDLSLNGASGAGVAAPVSTAAIELNDAGLPVGIPKSPTI------KPL 261

Human   174 QGSARGAKPHRCEACGKSFKYNSLLLKHQRIHTGEKPYACHECGKRFRGWSGFIQHHRIHTGEKP 238
            ...|.||.|::|..|.|:|...:.|::|.|.||||:|:.|..|.|.|........|.||||.|:|
  Fly   262 ANVAAGADPYQCNVCQKTFAVPARLIRHYRTHTGERPFECEFCHKLFSVKENLQVHRRIHTKERP 326

Human   239 YECGQCGRAFSHSSHFTQHLRIHNGEKPYKCGECGQAFSQSSNLVRHQRLHTGEKPYACSQ--CG 301
            |:|..|||||.||....:|:|||.||:|:||..|.:.|.||..||.|.|.|||||||.|.:  ||
  Fly   327 YKCDVCGRAFEHSGKLHRHMRIHTGERPHKCSVCEKTFIQSGQLVIHMRTHTGEKPYKCPEPGCG 391

Human   302 KAFIWSSVLIEHQRIHTGEKPYECSDCGKAFRGRSHFFR-HLRTHTGEKPFACGACGKAFGQSSQ 365
            |.|..|..|..|.|.|||||||.|..|.:.| |.:|..: |...|.|.|.:.|..|.:.|....:
  Fly   392 KGFTCSKQLKVHSRTHTGEKPYHCDICFRDF-GYNHVLKLHRVQHYGSKCYKCTICDETFKNKKE 455

Human   366 LIQHQRVHYRE 376
            :..|.:.|..|
  Fly   456 MEAHIKGHANE 466

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GLI4NP_612474.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..97 22/103 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 113..135 4/23 (17%)
COG5048 <181..343 CDD:227381 79/164 (48%)
zf-C2H2 183..205 CDD:278523 7/21 (33%)
C2H2 Zn finger 185..205 CDD:275368 7/19 (37%)
zf-H2C2_2 198..220 CDD:290200 11/21 (52%)
C2H2 Zn finger 213..233 CDD:275368 6/19 (32%)
zf-H2C2_2 228..250 CDD:290200 14/21 (67%)
C2H2 Zn finger 241..261 CDD:275368 10/19 (53%)
zf-H2C2_2 253..278 CDD:290200 11/24 (46%)
C2H2 Zn finger 269..289 CDD:275368 9/19 (47%)
zf-H2C2_2 281..304 CDD:290200 15/24 (63%)
C2H2 Zn finger 297..317 CDD:275368 9/21 (43%)
zf-H2C2_2 310..332 CDD:290200 12/21 (57%)
COG5048 321..>373 CDD:227381 16/52 (31%)
C2H2 Zn finger 325..345 CDD:275368 6/20 (30%)
zf-H2C2_2 337..360 CDD:290200 7/23 (30%)
C2H2 Zn finger 353..373 CDD:275368 4/19 (21%)
Kr-h1NP_477466.1 C2H2 Zn finger 196..216 CDD:275368 4/19 (21%)
COG5048 <270..420 CDD:227381 75/149 (50%)
zf-C2H2 271..293 CDD:278523 7/21 (33%)
C2H2 Zn finger 273..293 CDD:275368 7/19 (37%)
zf-H2C2_2 286..309 CDD:290200 11/22 (50%)
C2H2 Zn finger 301..321 CDD:275368 6/19 (32%)
zf-H2C2_2 313..338 CDD:290200 14/24 (58%)
C2H2 Zn finger 329..349 CDD:275368 10/19 (53%)
zf-H2C2_2 344..366 CDD:290200 11/21 (52%)
C2H2 Zn finger 357..377 CDD:275368 9/19 (47%)
zf-H2C2_2 370..396 CDD:290200 16/25 (64%)
C2H2 Zn finger 385..407 CDD:275368 9/21 (43%)
zf-H2C2_2 400..424 CDD:290200 13/24 (54%)
C2H2 Zn finger 415..435 CDD:275368 6/20 (30%)
zf-C2H2 441..463 CDD:278523 4/21 (19%)
C2H2 Zn finger 443..463 CDD:275368 4/19 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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