Protein Alignment GLI3 and jing

DIOPT Version :10

• Sequence 1: NP_000159.3
• Gene: GLI3 / 2737
• HGNCID: 4319
• Length: 1580
• Species: Homo sapiens
• Sequence 2: NP_001097200.1
• Gene: jing / 35555
• FlyBaseID: FBgn0086655
• Length: 1744
• Species: Drosophila melanogaster
• Alignment Length: 748
• Identity: 156/748 - (20%)
• Similarity: 251/748 - (33%)
• Gaps: 200/748 - (26%)

Human    24 STRTDVSEKAVASSTTSNEDESPGQTYHRERRNAITMQPQNVQGLSKVSEEPSTSSDERASLIKK 88
            ||.|......:|::..:|.:.:...|    ..|:|.....|  .||.::   :|:...:.:::|.
  Fly   836 STNTATQPPPLAATNNTNSNTANNST----ASNSINHNASN--NLSNIN---NTAIQPQRAIVKP 891

Human    89 EIHGSL---PHVAEPSVPYRGTVFAMDPRNGYMEPHYHP--------------PHLFPAFHPP-- 134
            .:|.|.   |.|...|:|......|..|......|...|              |.:.....||
  Fly   892 PLHSSTQPPPLVTISSMPACSPAAASSPAAKRSLPAAKPYQKRLTAKGRVGTAPIIATPTTPPPL 956

Human   135 VPIDARHHEGRYHYD----------PSPIPPL------HMTSALSSSPTYPDLPFIRISP----- 178
            ||..|....|:....          |:|.|||      .:|..||.|...|.:.....:|
  Fly   957 VPTSATKELGQLRKSTGTTGTPTGTPTPTPPLVSIAPSKLTPTLSVSKQGPTMKLANSAPDLFDL 1021

Human   179 -HRNPTAASESPFSPPHPYINPYMDYIRS-----LHSSPSLS-------------------MISA 218
             ..:...|..|....|.|:.:|......|     :.|||:||                   :.|.
  Fly  1022 VKNSKLVAKVSQPLTPLPFSSPSSSSNGSHGSHGMRSSPALSTSNSCTLSAFSKIKVETTELASQ 1086

Human   219 TRGLSPTDAPHAGVSPAEYYHQMALLTGQRSPYA-------DIIPSAATAGTGA---IHMEYLHA 273
            |..|:.:..|...:.|..:..|:.    :|.|.:       |::|....:.:.:   ....|.|:
  Fly  1087 TGSLTSSSIPTISLKPQSFAGQLP----KREPESETDTLKHDLLPDCTNSNSNSNSCSSSTYSHS 1147

Human   274 MD---------STRFSSPRLSARPSRKRTLSISPLSDHSFDLQTMIR--TSPNSLVTILNNSRSS 327
            :.         ||...||..||.||     .:...|..:.:|....|  .|...:::.|..|...
  Fly  1148 VSSAADLSLEASTPAPSPSPSASPS-----GLGSPSPAASNLSASSRRAASQTDMLSELVTSSCI 1207

Human   328 SSASGSYGHLSASAISPALSFTYS---SAPVSLHMHQQILSRQQSLGSAFGHS------PPLIHP 383
            ||........:.|...|||....|   :.|:|          ..|.||:.|.|      ...:..
  Fly  1208 SSGGDDCSQATDSPPMPALPLAKSEDATTPIS----------TVSGGSSSGSSNYDEEDDKSVAS 1262

Human   384 APTFPTQRPIPGIPTVLNPVQVSSGPSESSQN-------------KPT--SESAVSSTGDP---M 430
            ..|..|.:.:..:||..:.:..|...||||.:             .||  :.||.||..|.   .
  Fly  1263 LETHQTHKRLRDLPTPESGIGGSLSNSESSNSIADAISSKSASVGPPTTAASSASSSASDSNSLA 1327

Human   431 HNKRSKIKPDE--DLPSP--GARGQQEQPEGTTL---VKEEGDKDESK-------QEPEVI---- 477
            .|..|...|::  ..|||  .|......|..|.:   :.|...|...|       .:|:.|
  Fly  1328 SNAPSPASPEDCSAAPSPACSASTTGSIPPSTVVDIAMVEATSKSLPKSAISPILSQPKTIRFPA 1392

Human   478 -----------YETNCHWEGCAREFDTQEQLVHHINNDHIHGEKKEFVCRWLDCSREQKPFKAQY 531
                       ::..|:|:.|.::.::..:|:.|:...|::.:...|.|.|:.|....|...::.
  Fly  1393 GAGASGKGGKRHDGVCYWDKCNKKHESNSKLLDHMQTHHVNTQTGPFACLWVGCKVYNKESCSRR 1457

Human   532 MLVVHMRRHTGEKPHKCTFEGCTKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKH 596
            .|..|:..|.|.|..||..|||...:.....|:.|:.:|                 .||:|.|:.
  Fly  1458 WLERHVLSHGGSKQFKCIVEGCGLRFGSQLALQKHVNNH-----------------FNATDNARE 1505

Human   597 QNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVK 629
            .....:::.|.             |..|||:.|
  Fly  1506 STSKRTSDPPV-------------PKQLRKNGK 1525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GLI3	NP_000159.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..79		12/54 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	368..475		33/144 (23%)
		SFP1	<542..632	CDD:227516	20/88 (23%)
		C2H2 Zn finger	548..570	CDD:275368	6/21 (29%)
		C2H2 Zn finger	578..601	CDD:275368	4/22 (18%)
		C2H2 Zn finger	609..630	CDD:275368	5/21 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	620..728		5/10 (50%)
		Mediates interaction with DZIP1. /evidence=ECO:0000250|UniProtKB:Q61602	745..845
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	863..918
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	981..1042
jing	NP_001097200.1	C2H2 Zn finger	1411..1430	CDD:275368	3/18 (17%)
		C2H2 Zn finger	1441..1466	CDD:275368	6/24 (25%)
		C2H2 Zn finger	1474..1496	CDD:275368	6/21 (29%)