Protein Alignment GLI2 and lmd

DIOPT Version :10

• Sequence 1: XP_054197371.1
• Gene: GLI2 / 2736
• HGNCID: 4318
• Length: 1670
• Species: Homo sapiens
• Sequence 2: NP_732811.1
• Gene: lmd / 42717
• FlyBaseID: FBgn0039039
• Length: 866
• Species: Drosophila melanogaster
• Alignment Length: 838
• Identity: 213/838 - (25%)
• Similarity: 296/838 - (35%)
• Gaps: 276/838 - (32%)

Human   150 MRHQEGRY---------HYEPHSVHGVHGPPALSGSPVISDISLIRLSPHPAGPGESPFNAPHPY 205
            |.:|:|:|         .:||..:..:.|...|.|           :..||..| .:|:....||
  Fly   124 MPYQQGQYTQLNREDIFRFEPEDIARLTGESELPG-----------MLQHPQTP-YTPYTPYTPY 176

Human   206 ------------------VNPHMEHY------LRSVHSSP------------TLSMISAARGLSP 234
                              :|..::::      .:|.:.||            .|..||||...|.
  Fly   177 TPCSAQNSQYAVQPANDSINLDIDYFNYDEINCQSKNQSPCSSPHLDAWLNFNLGEISAAASSSA 241

Human   235 A-----DVAQEHLKERGLFGLPAPGTTPSDYYHQMTLVAGHP-------APYGDL--LMQSGGAA 285
            |     :|.:|.:||..     :|...||     |....|.|       :.|.|.  |.|.|...
  Fly   242 ASPKLGNVFEEQVKEEA-----SPAKLPS-----MNSTFGTPKCIPMCASNYEDYANLYQQGSGY 296

Human   286 SAPHLHDYLNPVDVSRFSSPRVTPRLSRKRALSISPLSDASLDLQRMIRTSPNSLVAYINNSRSS 350
            |..:.|:.:..| |.:       |....|...:|..|.:..|..|:.          ::.:
  Fly   297 STENYHNNMAQV-VEK-------PNREHKAIWTIDELDELMLGEQQQ----------FLQH---- 339

Human   351 SAASGSYGHLSAGALSPAFTFPHPINPVAYQQILSQQRGLGSAFGHTPPLIQPSPTFLAQQPMAL 415
                    ||.                  .|.:..||..|....|
  Fly   340 --------HLQ------------------QQHLQEQQEQLHQPHG-------------------- 358

Human   416 TSINATPTQLSSSSNCLSDTNQNKQSSESAVSSTVNPVAIHKRSKVKTEPEGL------RPASPL 474
                    |...:.||..|. .|..|.|...:.....:..........|.:.|      .||.
  Fly   359 --------QEQQTQNCKDDL-VNYLSDEFIKAEEFRSLDSDDDENYNEEEDDLDNDVFAPPAE-- 412

Human   475 ALTQGQVSGHGSCGCALPLSQEQLADLKEDLDRDDCKQEAEVVIYETNCHWEDCTKEYDTQEQLV 539
                                    :|.|.|....|.:.|.|..:....|.|..|.:|:..|:..|
  Fly   413 ------------------------SDPKPDSTCCDPEAEPENEVIPLICRWTGCDEEFPHQQAFV 453

Human   540 HHINNEHIHGEK-KEFVCRWQACTREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLEN 603
            .||...|:...| ::|.|.|..|.|..|||.|:|.|::|||.|:||||:||.|.||:||:|||||
  Fly   454 EHIEKCHVDVRKGEDFSCFWLDCPRRYKPFNARYKLLIHMRVHSGEKPNKCPFPGCNKAFSRLEN 518

Human   604 LKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYICKIPGCTKRYTDPSSLRKH 668
            ||.|.||||||:||.|:::||.|||||:||||||| |||.:.|||.|::||||||||||||||||
  Fly   519 LKIHQRSHTGERPYGCQYKGCLKAFSNSSDRAKHQ-RTHYDTKPYACQLPGCTKRYTDPSSLRKH 582

Human   669 VKTVHGPDAHVTKKQRNDVHLRTPLLKENGDSEAGTEPGGPESTEASSTSQAVEDCLHVRAIKTE 733
            ||.      |..:.....       |:......|...|.||:  :|:.|.:..|..|..|.:...
  Fly   583 VKN------HALRNANGQ-------LRRKSAGGASVPPSGPK--KAAKTRRHSESALVQRGVGAG 632

Human   734 SSGLCQSSPGAQ-----SSCSS---------------------EPS----------PLGSAPNND 762
            ......|:||.|     :|||.                     :|.          ..|.|.||:
  Fly   633 VGVAVPSAPGDQRQHRSNSCSEALLLQQHQQQQQQQQQQQKQHQPENERTTDRSNCGTGVAANNN 697

Human   763 S---------------GVEMPGTGPGSLGDLTAL---------DDTPPGADTSALAAPSAGGLQL 803
            |               .......||.:|...||.         .:..|..:|..|:..|.||
  Fly   698 SMNFNELSNCIVIIEHNQSGGPAGPATLATATATTTATATYGNGNMAPAPETEVLSVCSGGG--- 759

Human   804 RKHMTTMHRFEQLKKEKLKSLKDSCSWAGPTPHTRNTKLPPLPGSGSILENFSGSGGG 861
            ..:..:.:........:|..|:...:.|.|      |..|....:|..|.|.:|...|
  Fly   760 SSNSNSNNNRYNANINQLSELEQLLTTAKP------TGTPAASANGISLANNNGRANG 811

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GLI2	XP_054197371.1	PRK12323	<19..166	CDD:481241	6/24 (25%)
		SFP1	<583..673	CDD:227516	67/89 (75%)
		C2H2 Zn finger	589..611	CDD:275368	15/21 (71%)
		C2H2 Zn finger	619..642	CDD:275368	16/22 (73%)
		C2H2 Zn finger	650..671	CDD:275368	18/20 (90%)
		PHA03247	<996..1473	CDD:223021
lmd	NP_732811.1	SFP1	<493..585	CDD:227516	69/92 (75%)
		C2H2 Zn finger	504..526	CDD:275368	15/21 (71%)
		C2H2 Zn finger	534..556	CDD:275368	16/22 (73%)
		C2H2 Zn finger	564..586	CDD:275368	19/27 (70%)