DRSC/TRiP Functional Genomics Resources

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Protein Alignment GLI2 and esg

DIOPT Version :10

Sequence 1:XP_054197371.1 Gene:GLI2 / 2736 HGNCID:4318 Length:1670 Species:Homo sapiens
Sequence 2:NP_476600.1 Gene:esg / 34903 FlyBaseID:FBgn0287768 Length:470 Species:Drosophila melanogaster


Alignment Length:480 Identity:112/480 - (23%)
Similarity:174/480 - (36%) Gaps:151/480 - (31%)


- Green bases have known domain annotations that are detailed below.


Human   289 HLHDYLNPVDVSRFSSPRVTPRLSRKRALSISPLSDASL----------------------DLQR 331
            |:.:....|||...|.|..|...:...|.:::..:.||:                      :..|
  Fly    80 HIEEEDEDVDVDVDSDPNQTQAAALAAAAAVAAAAAASVVVPTPTYPKYPWNNFHMSPYTAEFYR 144

Human   332 MIRTSPNSLVAYINNSRSSSAASGSYGHLS----------AGALSPAFTFPHPINPVAYQQ---- 382
            .|....:.::....:..:.|:.|.|.|.||          |.::||.........|:..:|    
  Fly   145 TINQQGHQILPLRGDLIAPSSPSDSLGSLSPPPHHYLHGRASSVSPPMRSEIIHRPIGVRQHRFL 209

Human   383 ILSQQRGLGSAFGHT------PPLIQPSPTFLAQQPMALTSINATPTQLSSSSNCLSDTNQNKQS 441
            ...|..|..|..|:|      .|:   ||.:......::.|:  ||     .|:|.|...::...
  Fly   210 PYPQMPGYPSLGGYTHTHHHHAPI---SPAYSENSYYSMRSM--TP-----ESSCSSSLPEDLSL 264

Human   442 SESAVSSTVNPVAIHKRSKVKT---EPEGLRPASPLALTQGQVSGHGSCGCALPLSQEQLADLKE 503
            ....::..:|.....:::..||   .||.:..||                            .|:
  Fly   265 KHKNLNLNLNTSQPGEQAAAKTGDMSPETMPNAS----------------------------AKK 301

Human   504 DLDRDDCKQEAEVVIYETNCHWEDCTKEYDTQEQLVHHINNEHIH-----GE--KKEFVCRWQAC 561
            |.::....|          |  .||.|.|.|...|..|   :..|     |.  ||.|.|:  .|
  Fly   302 DKNQPPRYQ----------C--PDCQKSYSTFSGLTKH---QQFHCPAAEGNQVKKSFSCK--DC 349

Human   562 TREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNK 626
               .|.:.:...|.:|:|.||  .|.||..  |.||:||...|:.|:|:||||||:.|:|  |::
  Fly   350 ---DKTYVSLGALKMHIRTHT--LPCKCNL--CGKAFSRPWLLQGHIRTHTGEKPFSCQH--CHR 405

Human   627 AFSNASDRAKHQNRTHSNEKPYICKIPGCTKRYTDPSSLRKHVKTVHGPDAHVTKKQRNDVHLRT 691
            ||::.|:...|. :|||:.|.|.|  ..|:|.::..|.|.||                       
  Fly   406 AFADRSNLRAHL-QTHSDIKKYSC--TSCSKTFSRMSLLTKH----------------------- 444

Human   692 PLLKENGDSEAGTEPGGPESTEASS 716
                    ||.|. |||...:.:||
  Fly   445 --------SEGGC-PGGSAGSSSSS 460

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GLI2XP_054197371.1 PRK12323 <19..166 CDD:481241
SFP1 <583..673 CDD:227516 36/89 (40%)
C2H2 Zn finger 589..611 CDD:275368 9/21 (43%)
C2H2 Zn finger 619..642 CDD:275368 7/22 (32%)
C2H2 Zn finger 650..671 CDD:275368 7/20 (35%)
PHA03247 <996..1473 CDD:223021
esgNP_476600.1 KREPA <278..>329 CDD:483960 17/93 (18%)
zf-C2H2 309..331 CDD:395048 9/36 (25%)
C2H2 Zn finger 311..331 CDD:275370 8/24 (33%)
zf-C2H2 344..366 CDD:395048 7/26 (27%)
C2H2 Zn finger 346..366 CDD:275368 6/24 (25%)
zf-C2H2 370..392 CDD:395048 10/23 (43%)
C2H2 Zn finger 372..392 CDD:275368 9/21 (43%)
zf-H2C2_2 385..408 CDD:463886 13/24 (54%)
zf-C2H2 398..420 CDD:395048 7/24 (29%)
C2H2 Zn finger 400..420 CDD:275368 7/22 (32%)
C2H2 Zn finger 428..444 CDD:275368 5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

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