Protein Alignment GLI1 and lmd

DIOPT Version :10

• Sequence 1: NP_005260.1
• Gene: GLI1 / 2735
• HGNCID: 4317
• Length: 1106
• Species: Homo sapiens
• Sequence 2: NP_732811.1
• Gene: lmd / 42717
• FlyBaseID: FBgn0039039
• Length: 866
• Species: Drosophila melanogaster
• Alignment Length: 571
• Identity: 167/571 - (29%)
• Similarity: 236/571 - (41%)
• Gaps: 143/571 - (25%)

Human   192 EEPLEGDMSSPNSTGIQDPLLGMLDGREDLEREEKREPES-VYETDCRWDGCSQEFDSQEQLVHH 255
            |:.|:.|:.:|.:.....|        :....:.:.|||: |....|||.||.:||..|:..|.|
  Fly   399 EDDLDNDVFAPPAESDPKP--------DSTCCDPEAEPENEVIPLICRWTGCDEEFPHQQAFVEH 455

Human   256 INSEHIHGER-KEFVCHWGGCSRELRPFKAQYMLVVHMRRHTGEKPHKCTFEGCRKSYSRLENLK 319
            |...|:...: ::|.|.|..|.|..:||.|:|.|::|||.|:||||:||.|.||.|::|||||||
  Fly   456 IEKCHVDVRKGEDFSCFWLDCPRRYKPFNARYKLLIHMRVHSGEKPNKCPFPGCNKAFSRLENLK 520

Human   320 THLRSHTGEKPYMCEHEGCSKAFSNASDRAKHQNRTHSNEKPYVCKLPGCTKRYTDPSSLRKHVK 384
            .|.||||||:||.|:::||.|||||:||||||| |||.:.|||.|:|||||||||||||||||||
  Fly   521 IHQRSHTGERPYGCQYKGCLKAFSNSSDRAKHQ-RTHYDTKPYACQLPGCTKRYTDPSSLRKHVK 584

Human   385 TVHGPDAHVTKRHRGDGPLPRAPSISTVEPKREREGGPIREESRLTVPEGAMKPQPSPGAQSSCS 449
            .      |..:...|             :.:|:..||       .:||...    |...|::...
  Fly   585 N------HALRNANG-------------QLRRKSAGG-------ASVPPSG----PKKAAKTRRH 619

Human   450 SDHSPAGSAANTDSGVEMTGNAGGSTEDLSSLDEGPCIAGTGLSTLRRLENLRLDQLHQLRPIGT 514
            |:.:..........||.:....|...:..|:    .|.....|...::.:..:..|..|.:|...
  Fly   620 SESALVQRGVGAGVGVAVPSAPGDQRQHRSN----SCSEALLLQQHQQQQQQQQQQQKQHQPENE 680

Human   515 RGLKLPSLSHTGTTVSRRVGPPVSLERRSSSSSSISSAYTVSRRSSLASPFPPGSPPENGASSLP 579
            |           ||.....|..|:....|.:.:.:|:...:...:....|..|.:.....|::..
  Fly   681 R-----------TTDRSNCGTGVAANNNSMNFNELSNCIVIIEHNQSGGPAGPATLATATATTTA 734

Human   580 -------GLMPAQHYLLRARYASARGGGTSPTAASSLDRIGGLPMPPWRSRAEYPGYNPNAGVTR 637
                   .:.||.    .....|...||.|..:.|:.:|                 ||.|   ..
  Fly   735 TATYGNGNMAPAP----ETEVLSVCSGGGSSNSNSNNNR-----------------YNAN---IN 775

Human   638 RASDPAQAADRPAPARVQRFKSLGCVHTPPTVAGG-------GQ-------------NFD---PY 679
            :.|:..|......|           ..||...|.|       |:             :|:   .|
  Fly   776 QLSELEQLLTTAKP-----------TGTPAASANGISLANNNGRANGDSKCHLSEFVSFEYVTKY 829

Human   680 LPTSVY-----SPQPPSITENAAMDARGLQEEPEVGTSMVGSGLNPYMDFP 725
            | |.||     |||||:          ....:||...|.      ..:|||
  Fly   830 L-TDVYEPQCKSPQPPA----------NFHLQPEFDNSF------DMLDFP 863

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GLI1	NP_005260.1	Interaction with SUFU. /evidence=ECO:0000269|PubMed:24217340, ECO:0000269|PubMed:24311597	120..124
		FOXP-CC	237..>265	CDD:465036	12/27 (44%)
		Interaction with DNA. /evidence=ECO:0000269|PubMed:8378770	283..291		3/7 (43%)
		SFP1	<297..387	CDD:227516	67/89 (75%)
		C2H2 Zn finger	303..325	CDD:275368	14/21 (67%)
		C2H2 Zn finger	333..356	CDD:275368	16/22 (73%)
		Interaction with DNA. /evidence=ECO:0000269|PubMed:8378770	345..350		3/4 (75%)
		C2H2 Zn finger	364..385	CDD:275368	19/20 (95%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	375..485		24/109 (22%)
		Interaction with DNA. /evidence=ECO:0000269|PubMed:8378770	375..381		5/5 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	516..580		9/70 (13%)
		PHA03247	<562..1081	CDD:223021	39/199 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	732..792
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	817..889
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	914..942
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1054..1087
		SNAG domain. /evidence=ECO:0000250	1..20
lmd	NP_732811.1	SFP1	<493..585	CDD:227516	69/92 (75%)
		C2H2 Zn finger	504..526	CDD:275368	14/21 (67%)
		C2H2 Zn finger	534..556	CDD:275368	16/22 (73%)
		C2H2 Zn finger	564..586	CDD:275368	20/27 (74%)