Protein Alignment PRPF19 and PRP19

DIOPT Version :10

• Sequence 1: NP_055317.1
• Gene: PRPF19 / 27339
• HGNCID: 17896
• Length: 504
• Species: Homo sapiens
• Sequence 2: NP_013064.1
• Gene: PRP19 / 850623
• SGDID: S000003959
• Length: 503
• Species: Saccharomyces cerevisiae
• Alignment Length: 550
• Identity: 142/550 - (25%)
• Similarity: 219/550 - (39%)
• Gaps: 160/550 - (29%)

Human     3 LICSISNEVPEHPCVSPVSNHVYERRLIEKYIAENGTDPINNQPLSEEQLIDIKVA---HPIRPK 64
            ::|:||.:||..|.:||.|..::|:.|:|:|:.:.|.|||.|:|||.|::::|..:   ..:...
Yeast     1 MLCAISGKVPRRPVLSPKSRTIFEKSLLEQYVKDTGNDPITNEPLSIEEIVEIVPSAQQASLTES 65

Human    65 PPSAT-----SIPAILKALQDEWDAVMLHSFTLRQQLQTTRQELSHALYQHDAACRVIARLTKEV 124
            ..|||     |||.:|.:||:||||:||.:|.||..|.:..::||..:|:.|||..|.|:|..|.
Yeast    66 TNSATLKANYSIPNLLTSLQNEWDAIMLENFKLRSTLDSLTKKLSTVMYERDAAKLVAAQLLMEK 130

Human   125 TAAREALATLKPQAGLIVPQ-----AVPSSQPSVVGAGEPMDLGELVGMTPEIIQKLQDKATVLT 184
            ....:.|.....||..|..:     .:.||:..|.       .|:|......|::.|:    :|.
Yeast   131 NEDSKDLPKSSQQAVAITREEFLQGLLQSSRDFVA-------RGKLKAPKWPILKNLE----LLQ 184

Human   185 TERKKRG-KTVP-EELVKPEELSKY------RQVASHV--------------------GLHSASI 221
            .:...|. ||.| :||.|.....|:      ...|.|.                    |.|.|.|
Yeast   185 AQNYSRNIKTFPYKELNKSMYYDKWVCMCRCEDGALHFTQLKDSKTITTITTPNPRTGGEHPAII 249

Human   222 ------------PG--ILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVF 272
                        ||  |..||   |.|||:|      ..:..|.::|.|.  :.|| .:|.:..|
Yeast   250 SRGPCNRLLLLYPGNQITILD---SKTNKVL------REIEVDSANEIIY--MYGH-NEVNTEYF 302

Human   273 HPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQY---WAFSD 334
                             ||            |......|...:        ..|.||   .|.||
Yeast   303 -----------------IW------------ADNRGTIGFQSY--------EDDSQYIVHSAKSD 330

Human   335 IQ-TGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVAN-FP-GHSGPIT 396
            :: :..||.|       .||..|.:.|||:          :.:::|......:: || .....|.
Yeast   331 VEYSSGVLHK-------DSLLLALYSPDGI----------LDVYNLSSPDQASSRFPVDEEAKIK 378

Human   397 SIAFSENGYYLATAADDSSVKLWDLRK-----------LKNFK--TLQLDNNFEVKSLI-FDQSG 447
            .:.|::|||::.... |.:|..:||||           :..||  |:..|.:...|::| :....
Yeast   379 EVKFADNGYWMVVEC-DQTVVCFDLRKDVGTLAYPTYTIPEFKTGTVTYDIDDSGKNMIAYSNES 442

Human   448 TYLALGGTDVQIYICKQWTEILHFTEHSGL 477
            ..|.:...|.:   .|.||:    .|.|.|
Yeast   443 NSLTIYKFDKK---TKNWTK----DEESAL 465

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRPF19	NP_055317.1	RING-Ubox_PRP19	3..56	CDD:438318	22/52 (42%)
		May mediate interaction with PSMC5. /evidence=ECO:0000250|UniProtKB:Q99KP6	68..223		54/204 (26%)
		Prp19	69..133	CDD:400774	28/68 (41%)
		WD 1	219..259		15/53 (28%)
		WD40 repeat	224..262	CDD:293791	11/37 (30%)
		WD40	<233..504	CDD:441893	57/264 (22%)
		WD 2	262..301		6/38 (16%)
		WD40 repeat	268..304	CDD:293791	3/35 (9%)
		WD 3	304..345		11/44 (25%)
		WD40 repeat	309..344	CDD:293791	9/38 (24%)
		WD 4	348..387		7/38 (18%)
		WD40 repeat	354..389	CDD:293791	5/35 (14%)
		WD 5	390..429		13/51 (25%)
		WD40 repeat	395..431	CDD:293791	14/48 (29%)
		WD 6	433..472		8/39 (21%)
		WD40 repeat	438..464	CDD:293791	4/26 (15%)
		WD 7	473..503		2/4 (50%)
		WD40 repeat	476..502	CDD:293791	0/1 (0%)
PRP19	NP_013064.1	RING-Ubox_PRP19	1..53	CDD:438318	22/51 (43%)
		Prp19	75..132	CDD:400774	26/56 (46%)
		PRK11028	<385..459	CDD:182912	19/77 (25%)