Protein Alignment PRPF19 and prpf19

DIOPT Version :10

• Sequence 1: NP_055317.1
• Gene: PRPF19 / 27339
• HGNCID: 17896
• Length: 504
• Species: Homo sapiens
• Sequence 2: XP_031760828.1
• Gene: prpf19 / 448017
• XenbaseID: XB-GENE-975233
• Length: 504
• Species: Xenopus tropicalis
• Alignment Length: 504
• Identity: 427/504 - (84%)
• Similarity: 472/504 - (93%)
• Gaps: 0/504 - (0%)

Human     1 MSLICSISNEVPEHPCVSPVSNHVYERRLIEKYIAENGTDPINNQPLSEEQLIDIKVAHPIRPKP 65
            |||.|.|||||.:.||:||||.|:::|||||||:|||||||:.||||||:|||||||||||||||
 Frog     1 MSLTCYISNEVTDRPCISPVSGHIFDRRLIEKYLAENGTDPVTNQPLSEDQLIDIKVAHPIRPKP 65

Human    66 PSATSIPAILKALQDEWDAVMLHSFTLRQQLQTTRQELSHALYQHDAACRVIARLTKEVTAAREA 130
            |||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog    66 PSATSIPAILKSLQDEWDAVMLHSFTLRQQLQTTRQELSHALYQHDAACRVIARLTKEVTAAREA 130

Human   131 LATLKPQAGLIVPQAVPSSQPSVVGAGEPMDLGELVGMTPEIIQKLQDKATVLTTERKKRGKTVP 195
            |||||||||:.||||.|..|....|:.|.|:||||:||:.|||||||||||||||||||||||||
 Frog   131 LATLKPQAGISVPQASPMPQAGAAGSAEAMELGELIGMSAEIIQKLQDKATVLTTERKKRGKTVP 195

Human   196 EELVKPEELSKYRQVASHVGLHSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATL 260
            |:||||||||||.||:|||||||||:||||||||||:||||.|||||||:|||||..|:||||||
 Frog   196 EDLVKPEELSKYHQVSSHVGLHSASVPGILALDLCPTDTNKTLTGGADKSVVVFDALSQQILATL 260

Human   261 KGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSS 325
            ||||||||||||||||:||||||||:|||:||||:|||.||:||||.||||||||||||||||.|
 Frog   261 KGHTKKVTSVVFHPSQELVFSASPDSTIRVWSVPDASCAQVLRAHEGAVTGLSLHATGDYLLSCS 325

Human   326 DDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPG 390
            ||||||||||..||||||||||:|||:|||||||||||||||||:||||||||||||:|||||||
 Frog   326 DDQYWAFSDIHVGRVLTKVTDESSGCALTCAQFHPDGLIFGTGTVDSQIKIWDLKERSNVANFPG 390

Human   391 HSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGT 455
            ||||::.|||||||||||||||||||||||||||||||||||:..::|:||:|||||||||:|||
 Frog   391 HSGPVSCIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLEEGYQVRSLVFDQSGTYLAVGGT 455

Human   456 DVQIYICKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYSL 504
            |:|:||||||.|:||||:||.||||:|||.:|||:|||||||||:||||
 Frog   456 DIQVYICKQWAEVLHFTDHSALTTGLAFGQNAKFLASTGMDRSLRFYSL 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRPF19	NP_055317.1	RING-Ubox_PRP19	3..56	CDD:438318	38/52 (73%)
		May mediate interaction with PSMC5. /evidence=ECO:0000250|UniProtKB:Q99KP6	68..223		133/154 (86%)
		Prp19	69..133	CDD:400774	62/63 (98%)
		WD 1	219..259		32/39 (82%)
		WD40 repeat	224..262	CDD:293791	31/37 (84%)
		WD40	<233..504	CDD:441893	229/270 (85%)
		WD 2	262..301		33/38 (87%)
		WD40 repeat	268..304	CDD:293791	29/35 (83%)
		WD 3	304..345		36/40 (90%)
		WD40 repeat	309..344	CDD:293791	31/34 (91%)
		WD 4	348..387		34/38 (89%)
		WD40 repeat	354..389	CDD:293791	32/34 (94%)
		WD 5	390..429		35/38 (92%)
		WD40 repeat	395..431	CDD:293791	32/35 (91%)
		WD 6	433..472		26/38 (68%)
		WD40 repeat	438..464	CDD:293791	20/25 (80%)
		WD 7	473..503		22/29 (76%)
		WD40 repeat	476..502	CDD:293791	19/25 (76%)
prpf19	XP_031760828.1	RING-Ubox_PRP19	3..56	CDD:438318	38/52 (73%)
		Prp19	69..133	CDD:400774	62/63 (98%)
		WD40 repeat	224..262	CDD:293791	31/37 (84%)
		WD40	<233..504	CDD:441893	229/270 (85%)
		WD40 repeat	268..304	CDD:293791	29/35 (83%)
		WD40 repeat	309..344	CDD:293791	31/34 (91%)
		WD40 repeat	354..389	CDD:293791	32/34 (94%)
		WD40 repeat	395..431	CDD:293791	32/35 (91%)