DRSC/TRiP Functional Genomics Resources

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Protein Alignment PRPF19 and Prp19

DIOPT Version :9

Sequence 1:NP_055317.1 Gene:PRPF19 / 27339 HGNCID:17896 Length:504 Species:Homo sapiens
Sequence 2:NP_523783.1 Gene:Prp19 / 37123 FlyBaseID:FBgn0261119 Length:505 Species:Drosophila melanogaster


Alignment Length:510 Identity:336/510 - (65%)
Similarity:415/510 - (81%) Gaps:12/510 - (2%)


- Green bases have known domain annotations that are detailed below.


Human     1 MSLICSISNEVPEHPCVSPVSNHVYERRLIEKYIAENGTDPINNQPLSEEQLIDIKVAHPIRPKP 65
            |:|:|:::|||||.|.|||.|..|:|:|:||||:.|||.|||:.:.|..|:||:||....::|||
  Fly     1 MALVCALTNEVPETPVVSPHSGAVFEKRVIEKYLLENGCDPISGKELKPEELIEIKTPAVVKPKP 65

Human    66 PSATSIPAILKALQDEWDAVMLHSFTLRQQLQTTRQELSHALYQHDAACRVIARLTKEVTAAREA 130
            ||||||||.||.:||||||:|:||||.||||||||||||||||||||||||||||.|||.|||||
  Fly    66 PSATSIPATLKTMQDEWDALMIHSFTQRQQLQTTRQELSHALYQHDAACRVIARLNKEVAAAREA 130

Human   131 LATLKPQAGLI-VPQAVPSSQPSVV-----GAGEPMDLGELVGMTPEIIQKLQDKATVLTTERKK 189
            |||||||||:. .|.|:|  ||::.     .|..||   |..||:.|:||||||||||||.||||
  Fly   131 LATLKPQAGIANAPTAIP--QPALASEAGGAAAHPM---EQAGMSAEVIQKLQDKATVLTQERKK 190

Human   190 RGKTVPEELVKPEELSKYRQVASHVGLHSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSE 254
            ||:||||:||..:::..:..||||.||||||:|||||||:..:|.:||||||.|||..||:|.:|
  Fly   191 RGRTVPEDLVTTDQVKNFLTVASHPGLHSASVPGILALDINSADHSKILTGGNDKNATVFNKDTE 255

Human   255 QILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGD 319
            |::|.|||||||:|.|::||::|.|.:.|||..||||.||.:....::|.||..|||||||.|||
  Fly   256 QMVAILKGHTKKITKVIYHPNEDTVITGSPDMNIRIWHVPTSQTQLLLRCHEGPVTGLSLHPTGD 320

Human   320 YLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTN 384
            ||||:|.|::||||||:|||:||||.| |:...||.||||||||||||||:|||:|||||||::|
  Fly   321 YLLSTSSDKHWAFSDIRTGRLLTKVID-TAEVGLTTAQFHPDGLIFGTGTVDSQVKIWDLKEQSN 384

Human   385 VANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTY 449
            |||||||:|||::|:||||||||||||||:.||||||||||||||:|||:.:|||.|.|||||||
  Fly   385 VANFPGHTGPISAISFSENGYYLATAADDACVKLWDLRKLKNFKTIQLDDGYEVKDLCFDQSGTY 449

Human   450 LALGGTDVQIYICKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYSL 504
            ||:.|:||::|:||||.|:..|.:|:.|.|||.||.||:::|||.|||:||.|::
  Fly   450 LAIAGSDVRVYLCKQWQELKVFNDHTALATGVRFGKHAQYLASTSMDRTLKLYAI 504

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PRPF19NP_055317.1 RING-Ubox_PRP19 4..56 CDD:319570 28/51 (55%)
May mediate interaction with PSMC5. /evidence=ECO:0000250|UniProtKB:Q99KP6 68..223 110/160 (69%)
Prp19 69..133 CDD:400774 55/63 (87%)
WD 1 219..259 24/39 (62%)
WD40 223..503 CDD:238121 187/279 (67%)
WD40 repeat 224..262 CDD:293791 22/37 (59%)
WD 2 262..301 20/38 (53%)
WD40 repeat 268..304 CDD:293791 15/35 (43%)
WD 3 304..345 30/40 (75%)
WD40 repeat 309..344 CDD:293791 27/34 (79%)
WD 4 348..387 29/38 (76%)
WD40 repeat 354..389 CDD:293791 29/34 (85%)
WD 5 390..429 32/38 (84%)
WD40 repeat 395..431 CDD:293791 30/35 (86%)
WD 6 433..472 23/38 (61%)
WD40 repeat 438..464 CDD:293791 17/25 (68%)
WD 7 473..503 17/29 (59%)
WD40 repeat 476..502 CDD:293791 16/25 (64%)
Prp19NP_523783.1 Ubox 2..68 CDD:128780 35/65 (54%)
Prp19 69..132 CDD:285771 54/62 (87%)
WD40 210..503 CDD:238121 198/293 (68%)
WD40 <225..505 CDD:225201 187/281 (67%)
WD40 repeat 269..305 CDD:293791 15/35 (43%)
WD40 repeat 310..345 CDD:293791 27/34 (79%)
WD40 repeat 354..389 CDD:293791 29/34 (85%)
WD40 repeat 395..431 CDD:293791 30/35 (86%)
WD40 repeat 438..484 CDD:293791 27/45 (60%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165159718
Domainoid 1 1.000 131 1.000 Domainoid score I5160
eggNOG 1 0.900 - - E1_KOG0289
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H6421
Inparanoid 1 1.050 686 1.000 Inparanoid score I706
Isobase 1 0.950 - 0 Normalized mean entropy S1589
OMA 1 1.010 - - QHG54686
OrthoDB 1 1.010 - - D1049599at2759
OrthoFinder 1 1.000 - - FOG0003405
OrthoInspector 1 1.000 - - oto90088
orthoMCL 1 0.900 - - OOG6_102145
Panther 1 1.100 - - LDO PTHR43995
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R276
SonicParanoid 1 1.000 - - X2757
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1716.750

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